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Mathurin Dorel

@mathsrish.bsky.social

Cancer systems biologist. I'm poking at cancer cells to model how they work in details. #perturbation #model #highthroughout #targetedtherapy ORCID: 0000-0002-1663-2075

213 Posts405 Follower863 Folgt
Michael Le Page@mjflepage.bsky.social · 4mo ago

And his company did fail. The public Human Genome Project mapped the human genome first to help it assemble the pieces. Venter tried to beat them by skipping the mapping part but it didn't work and he ended up relying on HGP's map to assemble his version of the genome

Pedro Beltrao@pedrobeltrao.bsky.social · 4mo ago

It looks like Anthropic has included fake paper generation in their model alignment considerations and Claude tries to avoid doing it. Maybe we need to make more noise about this in general to get the others model developers onboard with this.

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John FitzGiraffe Kennedy@jgiraffekennedy.bsky.social · 5mo ago

2. The Slow Path: Go slow, verify everything, achieve frustration This is the “responsible adult” mode. The engineer tries to: - read every line - reconstruct intent - validate assumptions - check invariants - write tests the model should have written - rewrite, refactor, and fix all things (6)

Mathurin Dorel@mathsrish.bsky.social · 7mo ago

Wait, so ONT demonstrated that they solved protein nanopore sequencing, including three PTMs, on peptides with a few zeptomolar accuracy (1e-21 !, 6 molecules/mL) almost a year ago (finally catching up London calling 2025) and no-one made a big deal out of it ?? This is actually insane.

Mathurin Dorel@mathsrish.bsky.social · 8mo ago

Anyone with non existing reference in their paper should get publicly named and shamed, and barked from any scientific role forever. The continuity of knowledge is too important, we have to be able to trace the source of scientific claims.

Nathan Kalman-Lamb@nkalamb.bsky.social · 8mo ago

I’m sorry, but it is disgraceful to be an academic who uses this technology to conduct research. It should be prohibited in all of our scholarly institutions, including universities and journals.

Mathurin Dorel@mathsrish.bsky.social · 12mo ago

Anyone knows more about the new Russian cancer vaccine ? The most reliable info I could find in English is that it's 4 viruses. The new press releases also sound like the full treatment involves personalized mRNA and that it was tested in 48 patients with 100% success new.nmicr.ru/en/pacientam...

Cancer Vaccine - biotech solutions in the fight against cancer diseases

Oncolytic and personalized vaccines - clinical trials and patient enrollment for Phase I begins as early as late 2024, early 2025

new.nmicr.ru

laydgeur@laydgeur.bsky.social · last yr.

Je m’arrête là dessus un instant, car je vois souvent cette étude citée pour dire qu’en gros le recours à la clim augmenterait systématiquement la température de la ville de 2 à 3°C et que c’est bien la preuve que c’est pas une solution. Ce qui est complètement partiel et trompeur.

Mark A. Hanson@hansonmark.bsky.social · last yr.

If I could change one thing about #ScientificPublishing I'd ask funding bodies to stipulate all work they fund be published in non-profit journals. The knock-on effects would alleviate most of the strain on #AcademicSky. This isn't hard. It's big, but actually, it's pretty easy. 1/n

The strain on scientific publishing

Abstract. Scientists are increasingly overwhelmed by the volume of articles being published. The total number of articles indexed in Scopus and Web of Science has grown exponentially in recent years; ...

direct.mit.edu

Mathurin Dorel@mathsrish.bsky.social · last yr.

But if falls to less than 5% in winter, when Europe needs the most electricity. Notice on the left graph how wind, *gas* and *coal* take over. Europe needs to scale up nuclear and batteries big time, for the climate and for it's energy independence. (Hydro scale up is not possible sadly).

Nicolas Fulghum@nicolasfulghum.bsky.social · last yr.

NEW | Solar power was the EU’s biggest power source in June 2025 ☀️ For the first time, solar ranked first among all power sources, producing 22.1% of the EU’s power ahead of nuclear at 21.8%. Coal power fell to a record low 6.1% in sixth place.

Mathurin Dorel@mathsrish.bsky.social · last yr.

Nice thing about having a thermal camera on your phone is that you can quantify your suffering during a heat wave. You can also check if your insulation measures are working and how much worse it could get which is nice I guess.

Thermal imaging of a kitchen window. Temperature readings indicate 34.6C at the surface of the window and 29.6C for the wall.Thermal imaging of a fridge. Temperature reads 29.3C on the front and 35.8C on the side.Thermal imaging of a towel on drying rack in front of a window. Temperature reads 28.6C for the floor, 25.8C for the towel and 30.6C for the window.
Jen Christiansen@jenchristiansen.com · last yr.

Vaccination schedules on the CDC website have already started changing under RFK Jr. So we published a guide to the evidence-based vaccine recommendations in place *before* all 17 members of the advisory panel were abruptly dismissed by the new admin. www.scientificamerican.com/article/see-... 🧪

Here’s Your Cheat Sheet for Vaccine Recommendations Backed by Science

These graphics will guide you through science-based vaccine guidelines for children and adults

scientificamerican.com