In our new iScience paper we find that WNT7B marks specific pancreatic tumour cells that maintain a basal like state and correlate with more aggressive disease. WNT-high cells support the survival of neighbouring cells through cell-cell contact-dependent signalling. doi.org/10.1016/j.is...

Incredibly excited to join forces to develop new and unconventional approaches for #colorectalcancer treatment with the REWIRE-CAN team! @cancergrand.bsky.social @umcutrecht.bsky.social @oncodeinstitute.bsky.social @mauricelab.bsky.social

Cancer Grand Challenges@cancergrand.bsky.social · 5mo ago

📰 News announcement! www.cancergrandchallenges.org/new-teams-an... We’re thrilled to welcome five world-leading scientific teams, each awarded up to £20 million, to take on some of the toughest unanswered questions in #CancerResearch. Find out more about the teams and their challenges.

🚀 Big news from the Maurice lab! OutMARCH has secured an EIC Pathfinder grant to develop SureTACs, bispecific antibodies that degrade cancer driving membrane proteins, including previously undruggable targets. A new precision strategy to overcome therapy resistance in cancer. Thread 👇

Excited to share that work from my PhD in the @mauricelab.bsky.social has been published in @cp-iscience.bsky.social. ❔️Why do mutations in two Wnt pathway genes lead to different clinical features in hepatocellular carcinoma? 📄Read the paper for our insights: doi.org/10.1016/j.is...

Jelte van der Vaart, postdoc in our lab, has been awarded an NWO Veni grant! 🎉 He will develop human adrenal organoids to uncover how hormone producing cells change identity and function, shedding light on endocrine health. We're so proud of his achievement and will support him along the way 😁

Yesterday, @antonvenhuizen.bsky.social successfully defended his thesis "Molecular mechanisms of the β-catenin destruction complex in health and disease", which describes the versatile field of WNT regulator AXIN1. We are super proud and wish Dr. Venhuizen all the best in Cambridge!

Our Center for Molecular Medicine (cmmutrecht.eu) at UMC Utrecht, NL, is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but candidates with a more advanced career are very welcome to apply. shorturl.at/KZeYQ. Please repost!

Center for Molecular Medicine

cmmutrecht.eu

Want to learn the latest insights on how Wnt signaling controls cell behavior? Check out a new review by Madelon Maurice (@madelonmaurice.bsky.social) and Stephane Angers at @natrevmcb.bsky.social

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · 2y ago

✨ New #Review ✨ @madelonmaurice.bsky.social & Stephane Angers discuss the newest insights on #WntSignalling with a focus on biogenesis & transport of Wnts and Wnt receptor complex activation. 👉 go.nature.com/42ynuU0

Pre-print Alert! 📢 Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype www.biorxiv.org/content/10.1...

WNT7B drives a program for pancreatic cancer subtype switching and progression

Hyperactivation of WNT signaling is a well-established hallmark of cancer. Various epithelial cancers express high levels of WNT7B and WNT10A that are not commonly expressed during tissue homeostasis,...

biorxiv.org

🎉 Huge congratulations to Dr. Joep Sprangers! Yesterday, Joep successfully defended his PhD thesis and officially became a doctor! His studies describe the role of WNT7B and WNT10A in regeneration, homeostasis, and cancer. It was a very special day, couldn’t be prouder.

Yesterday, our lab turned festive for late Sinterklaas/early Christmas! 🎁 With poems, laughter, and guessing games, we shared stories, gifts, and some surprising personal details. Add drinks, snacks, and a digital fireplace, and it was a night of bonding, cheer, and fun!✨#LifeOutsideTheLab

Our first post on BlueSky is here 🦋. Great story from @antonvenhuizen.bsky.social from our lab describing the role of AXIN1 mutations in hepatocellular carcinoma. Congrats to Anton for the hard work and the deserved BioRxiv pre-publication! 🥳 www.biorxiv.org/content/10.1...

Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling

In healthy cells, AXIN1 organizes assembly of a large destruction complex that mediates proteolysis of the transcriptional co-activator β-catenin to prevent inappropriate Wnt/β-catenin pathway activat...

biorxiv.org

Anton Venhuizen@antonvenhuizen.bsky.social · 2y ago

Excited about our pre-print on AXIN1 mutations in HCC! We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.