Aniek Janssen

@aniekj.bsky.social

Associate Professor at University Medical Center Utrecht, the Netherlands. Views are my own. She/her. Lab website: https://www.aniekjanssen.org

@lucievleeuwen.bsky.social, a talented postdoc in my lab, in collaboration with the @hayleysharpe.bsky.social and Dansen lab, developed a variety of fly lines with redox sensors in different subcellular compartments, revealing distinct H2O2 patterns during development. Read more below!

Lucie van Leeuwen@lucievleeuwen.bsky.social · 2mo ago

New preprint! Excited to share #FlyPer: new #Drosophila lines targeting #H2O2 sensor #HyPer7 to the #mitochondria, #nucleus, #cytosol & #plasmamembrane! 🪰 Together with @sharpe-lab.bsky.social & Dansen lab, we reveal distinct H2O2 patterns in embryos and larval wing discs. doi.org/10.64898/202...

Sign up now for the EMBO meeting 'quantitative biology to molecular mechanisms'. Fantastic speaker lineup and plenty of speakers slots selected from abstracts. Submit your abstract before Sept 11!

EMBL Events@events.embl.org · 2mo ago

You only have until 11 Sep to submit your abstract for #EMBOomics! ➡️ s.embl.org/omx26-01-bl Join us to discuss the latest developments in the field with leaders in genomics, dynamic proteomics, quantitative imaging, and synthetic biology.

I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481

Assistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell Biology

University of California, Berkeley is hiring. Apply now!

aprecruit.berkeley.edu

Crete Fly 2026 is a wrap! brain overflowing with info, and heart full with joy, after a week of stimulating talks, discussions, and catching up with old and new friends spanning 30 years of my life. also rocked the OAC with Cassandra Extavour for the first time, the fly community is the BEST!! 🪰🇬🇷

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🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...

A dual role for CTCF in development

CTCF is an essential DNA binding protein whose absence leads to embryonic lethality. CTCF is primarily known for its role in 3D genome organization where its N-terminal domain interacts with cohesin to anchor chromatin loops. How CTCF facilitates proper embryonic development remains unclear, necessitating temporal control to resolve its stage-specific functions. By combining gastruloids, an in vitro model of embryonic development, with a degron system to rapidly deplete CTCF at defined timepoints, we show that early CTCF depletion impairs early gastruloid morphogenesis. Surprisingly, ATAC-seq and time-resolved RNA-seq revealed that differentiation was unaffected. CTCF binding is strongly enriched at promoters of downregulated genes. Re-expression of a CTCF variant with an N-terminal truncation, incapable of looping, was sufficient to rescue the expression of CTCF-promoter bound genes and the defects in morphogenesis. However, extended culture (up to 168 hours) of gastruloids reconstituted with N-terminal truncated CTCF led to their collapse. Our work shows that CTCF has a dual function in early mammalian development: at early stages CTCF regulates developmentally important genes through promoter binding, while at later stages its looping function is required for correct development. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 637587, 865459 Dutch Research Council, https://ror.org/04jsz6e67, 016.161.316, VI.C.222.049 Dutch Cancer Society, https://ror.org/0368jnd28, N/A

biorxiv.org

My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression. info and application here institut-curie.org/job/study-en....

Study Engineer (F/M) - Institut Curie

The Curie Institute Research CenterThe Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a str...

institut-curie.org

1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...

An electrostatic repulsion model of centromere organisation

During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...

doi.org

Please please please, if you are able, consider supporting Flybase fiscally. They need our help! I donated this evening. They are in danger of closing and any amount will help. We cannot allow this critical pillar of science to collapse!

FlyBase@flybase.bsky.social · last yr.

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research. By @claudia-lopez.bsky.social www.thetransmitter.org/community/ha...

Harvard University lays off fly database team

The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

thetransmitter.org

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences

Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

lms.mrc.ac.uk

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

The Groth lab@grothlab.bsky.social · 2y ago

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.

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