#Book_Recommendation As labs grow, bottlenecks change. We study how aging and chemotherapy disrupt metabolic supply chains in the body. Now we are applying the same systems thinking to the lab itself. This month we recommend Andrew Grove’s High Output Management. www.amazon.com/dp/067976288...

Why do aged or injured cells lose their ability to stay metabolically lean when nutrients are abundant? We’re happy to welcome Saiprahalad Mani, joining us from Ludwig-Maximilians-Universität München for his MSc practical work. Welcome to the Aging and Cancer Lab, Sai!

Hematopoietic stem cells face a central choice: divide or stay dormant. In our lab seminar series, Patricia Herrero shared how this decision is shaped — and how aging and cancer therapy may reshape it. Thanks to Patricia and the Bigas Lab for an inspiring seminar.

#JournalClub Colorectal cancer is often taught as one clone expanding toward malignancy. But what if early lesions are polyclonal? Hu, He and colleagues propose that multiple clones can cooperate early, before later transition toward monoclonal states. www.nature.com/articles/s41...

Polyclonal-to-monoclonal transition in colorectal precancerous evolution - Nature

Experiments using DNA barcoding for lineage tracing in mouse models of colorectal cancer reveal polyclonal origins of premalignant lesions, with a transition to monoclonality as they pr...

nature.com

An almost empty 1970s-looking bar. An elderly owner solving crosswords. A few rundown tables. Two board games. Not the obvious setting for a lab memory. But playing miners and saboteurs there will quietly become part of our lab’s history.

What if precancerous selection is local? Young et al. show that, in human bone marrow, clonal architecture can vary substantially within just millimeters of space. A clue that local microenvironments may shape which clones expand. #JournalClub aacrjournals.org/bloodcancerd...

Can the aged tissue microenvironment help predict cancer recurrence? Welcome Adelina Gheorghe, a medical oncologist joining our team to test this question in the clinic and help move our findings toward better patient care.

Your epigenome may record the exposures of your life. At our Aging & Cancer Lab seminar, Silvana Maas (Seoane Lab) showed how lifestyle and environmental exposures leave marks on DNA that can be decoded to reconstruct exposures linked to early-onset colorectal cancer. #Aging&CancerLabseminars

Eric J. Chow et al. find that dexrazoxane given with doxorubicin in childhood cancer is linked to improved long-term cardiac function and lower risk of poor left ventricular function in adult survivors. #JournalClub ascopubs.org/doi/10.1200/...

Dexrazoxane and Long-Term Heart Function in Survivors of Childhood Cancer

PURPOSEFor survivors of childhood cancer treated with doxorubicin, dexrazoxane is cardioprotective for at least 5 years. However, longer-term data are lacking.METHODSWithin the Children's Oncology Gro...

ascopubs.org

Piotr et al. report that intravenous iron in a mouse cancer model increases tumor iron, promotes tumor growth, and blunts anti-tumor CD8⁺ T cell responses, reducing immunotherapy/chemo efficacy. #JournalClub www.frontiersin.org/journals/onc...

Frontiers | Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function

Iron is both, an essential compound for many metabolic processes, and iron deficiency can impact on the proliferation of cells including lymphocytes but al...

frontiersin.org

A shared DNA methylation drift occurs with aging and tumorgenesis in the colon. Age-related inflammation and reduced Wnt signaling, which dysregulate iron metabolism and impair TET activity, drive this epigenetic drift. #JournalClub www.nature.com/articles/s43...

Iron homeostasis and cell clonality drive cancer-associated intestinal DNA methylation drift in aging - Nature Aging

Krepelova and colleagues identify an aging- and colon cancer-associated DNA methylation drift in healthy and cancerous human colon samples, echoed in the mouse intestinal epithelium. They show it expa...

nature.com

Ferritin buffers intracellular iron and protects cells from iron toxicity. Yi et al. show that deleting the ferritin heavy chain (Fth1) impairs normal HSPC function but restricts AML progression and prolongs survival in mice. #JournalClub www.nature.com/articles/s41...

Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells - Leukemia

Leukemia - Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells

nature.com

When Ning, Francesca & Marc were selected to speak @senescel.org 2025, they gave it their all, refining every argument and minute. Their talks put our metabolic bottleneck model of aging on the field’s radar. 👏 What do you think drives tissue aging, the cell or its environment? 🤔

Postdoc | VHIO, Barcelona Immunotherapies succeed in only ~20% of cases. Help us break resistance by engineering the right environment. Join the Aging & Cancer Lab 🌍 👉 Apply: vhiovidaprogramme.eu/recruitment/ | mauslab.org

📖Culture dishes and in vivo studies are not our only experiments. As our lab turns soon 3, we keep on testing how to grow a culture where ideas and people thrive. For anyone curious about the science of teamwork, The Culture Code is a brilliant field guide. 📖 #LabReads

📃By integrating single-cell RNA sequencing datasets, Cong et al. characterize the evolution and interactome of hematopoietic niche from embryonic development to aging. #JournalClub pubmed.ncbi.nlm.nih.gov/39698109/

Deciphering the evolving niche interactome of human hematopoietic stem cells from ontogeny to aging - PubMed

Hematopoietic stem cells (HSC) reside within specialized microenvironments that undergo dynamic changes throughout development and aging to support HSC function. However, the evolving cell-cell commun...

pubmed.ncbi.nlm.nih.gov

Lung cancer reprograms the bone marrow to its advantage. Hedge et al. ( @miriammerad.bsky.social lab) show that tumors trigger an NRF2-driven stress response in myeloid precursors, which then suppress anti-tumor immunity. Blocking NRF2 boosts immunotherapy. #JC 🔗 www.nature.com/articles/s41...

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature

An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and developing more effective myeloid-targeting therapies.

nature.com

#CCESumSchool25 Day 2 🧬 • Lectures: Fundamental Research, Patient-centered Research, Proteomics • Workshop: Patient Involvement • First Poster Session! @vhio.bsky.social @nkinl.bsky.social @nct-heidelberg.bsky.social @gustaveroussy.fr @ki.se @zwartlab.bsky.social @mauslab.bsky.social

Hear from Aistė Avižaitė, who joined us from Lithuania to explore aging & cancer and grow in translational oncology at @vhio.bsky.social. ▶️https://youtube.com/shorts/q0g6zdywe6s

📰 In aging bone marrow, cancerous clones thrive by adapting through mutations. Kang et al. show that giving immune cells the same mutations tilts the balance back—helping them resist exhaustion and fight cancer in this hostile niche. #JournalClub 🔗 www.science.org/doi/10.1126/...

Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy

Epigenetic reinforcement of T cell exhaustion is known to be a major barrier limiting T cell responses during immunotherapy. However, the core epigenetic regulators restricting antitumor immunity duri...

science.org

📰Aging disrupts metabolic supply chains, constraining cell renewal. But how do we detect these shortages? In >5000 patients, Tapio et al. show that low ferritin is the best predictor for bone marrow iron. A study with broad implications. hashtag #JournalClub 🔗 ashpublications.org/bloodadvance...

📑Why don’t senescent cells fix their DNA? Daigh et al. (Meyer lab) report that uncoupling mTORC1 from E2F sustains transcription-linked DNA damage in senescence. #JournalClub www.nature.com/articles/s41...

Why do TET2-mutant preleukemic cells outcompete healthy HSCs? Yang et al. show that these cells upregulate MPL (thrombopoietin receptor, TPO-R) signaling, giving a clonal edge; inhibiting this pathway reduces it. #JournalClub www.nature.com/articles/s41...

TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling - Nature Communications

Clonal hematopoiesis is associated with an increased risk of hematologic and a range of inflammation-related diseases. Here, Yang et al. demonstrate a critical role for aberrant thrombopoietin recepto...

nature.com

Why do ring sideroblasts arise in MDS? Often via SF3B1-driven mitochondrial iron buildup. Inokura et al. tested TET2’s role: Tet2-deficient mice show systemic iron overload, and anemia. No classical RS, but intriguing parallels. #JournalClub www.exphem.org/article/S030...

Impact of TET2 deficiency on iron metabolism in erythroblasts

Sideroblastic anemia is characterized by the presence of ring sideroblasts (RSs), which are caused by iron accumulation in the mitochondria of erythroblasts and are present in both the acquired and co...

exphem.org

🌱We are delighted to welcome Gloria Ariño from Universidad Europea de Madrid as our third summer intern!🌟 Gloria will explore how aging creates metabolic bottlenecks in the colon and how these shape tumorigenesis. With Gloria, Laura & Aiste, our summer intern dream team is complete!💪

📑Immunotherapy responses differ markedly between MMR-proficient and -deficient colorectal cancers. A scRNA-seq study of 62 patients by ‪@pelkalab.bsky.social‬ et al. (Hacohen lab) reveals key immune–tumor communication differences that may explain this. #JournalClub www.cell.com/cell/fulltex...

Spatially organized multicellular immune hubs in human colorectal cancer

Single-cell transcriptomics-based co-variation analysis of human colorectal cancer identifies a spatially resolved myeloid-rich inflammatory hub that is shared by mismatch repair-deficient (MMRd) and ...

cell.com

🎯 The Aging and Cancer Lab is not afraid of tough battles — in science or laser tag. What connects aging and cancer? Can we stop it? We team up and take aim together at the route causes.. 🔬💥

🌱Excited to welcome Aistė Avižaitė from Lithuania’s @VU_LT to the lab this summer! She’ll be studying how chemotherapy alters metabolism in healthy tissues and how this may drive accelerated aging in childhood cancer survivors. #Aging #Cancer #SummerIntern

200 years ago in Barcelona, your 40s meant preparing for death. Today, you might have 40 more years ahead. But as @sjayolshansky et al. show, most gains came from reducing early death. Further progress depends on tackling aging and its consequences. #JC www.nature.com/articles/s43...

Implausibility of radical life extension in humans in the twenty-first century - Nature Aging

In the twentieth century, human life expectancy rose dramatically. Based on the past three decades of observed mortality in the eight countries with the longest-lived populations and in Hong Kong and ...

nature.com

🌱 Welcome aboard, Laura! Joining us this summer from @URV_universitat, Laura Boró García will be exploring how aging and chemotherapy disrupt metabolism and epigenetics in the bone marrow. We’re thrilled to have her with us! 🧬🧪 #Aging #Cancer #SummerIntern