Exciting new research in @jem.org: a fully nonviral, plasmid-based knock-in platform for CAR-NK cells, w/ ~90% editing efficiency, up to 100% cell recovery, and payloads >5kb. Engineered using MaxCyte's ExPERT GTx®, with GMP-compatible manufacturing at clinical scale. 🔗 https://bit.ly/44rrLs4
Reprogramming endogenous NK circuits by highly efficient nonviral genome editing
We developed a highly efficient nonviral knock-in platform for NK cells, enabling plasmid-based genome editing with up to ∼90% knock-in efficiency and ∼100
rupress.org