Excited to finally share my recent preprint with @struangrant.bsky.social! www.biorxiv.org/content/10.6... We collected chromatin accessibility QTLs (caQTLs) from 10 different studies and observed that they are less depleted at selectively constrained genes compared to eQTLs. 👇👇👇

I'll be at #ASHG25 this week! Check out my poster Wed 2:30-4:30, at 5071W. "Bridging the GWAS-eQTL colocalization gap with insights from caQTL analyses" with @struangrant.bsky.social and Laura Almasy

My foray into video creation! This is my entry into #SoME4, an annual exposition of math-explainers. A friendly introduction to hypothesis testing, with minimal math background required. www.youtube.com/watch?v=qEE0rzytHls

What is a p-value? #SoME4

YouTube video by Max Dudek

youtube.com

The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs: probgen2026.github.io Please help spread the news.

Check out @maxdudek.bsky.social paper on fpQTLs! www.cell.com/ajhg/fulltex...

The American Journal of Human Genetics@ajhgnews.bsky.social · last yr.

Our June issue is online! Check out the latest human #genetics & #genomics research

Our new paper is out today in AJHG! We applied a "footprinting" algorithm to ATAC-seq data from 170 livers to find non-coding variants associated with TF binding. We show that these "footprint QTLs" (#fpQTLs) can fine-map GWAS loci at base-pair resolution. www.cell.com/ajhg/fulltex...

Characterization of non-coding variants associated with transcription-factor binding through ATAC-seq-defined footprint QTLs in liver

Dudek et al. use chromatin accessibility data in liver from 170 human donors to measure transcription factor binding at genetic variants. They observed 809 variants associated with binding. Given bind...

cell.com

This is one of those videos that you could work on forever, but suddenly it felt very important to make it, so I finally did: www.youtube.com/watch?v=d8Pn...

Populism, Media Revolutions, and Our Terrible Moment

YouTube video by vlogbrothers

youtube.com

Good to see @maxdudek.bsky.social on here now - here’s his recent preprint

Struan Grant@struangrant.bsky.social · 2y ago

PREPRINT: Co-mentored with Laura Almasy, & formerly Casey Brown, @cambupenn.bsky.social grad student Max Dudek reports non-coding variants associated with TF binding via ATAC-seq-defined footprint QTLs (#fpQTLs) across 170 liver samples (generated by Brandon Wenz). www.biorxiv.org/content/10.1...