Struan Grant
@struangrant.bsky.social
Professor of Genetics and Pediatrics, UPenn/CHOP🧬. https://orcid.org/0000-0003-2025-5302. Views my own. 🏴🇺🇸
In @genomeresearch.bsky.social: @atothezphd.bsky.social "Cross-species variant-to-function analyses implicate MEIS1 in conferring sleep abnormalities and impaired cerebellar development". Co-led with Allan Pack @chopresearch.bsky.social @penngenetics.bsky.social genome.cshlp.org/content/earl...
Had a fantastic 4th of July watching France beat Paraguay in Philadelphia!
Great game today. Obviously not the result we wanted. Roll on Brazil! 🏴⚽️
Great debate at the ECTS annual meeting @ectssociety.bsky.social . With Hanna Taipaleenmaki for the motion and Maria Ines Almeida against. Interestingly, lncRNAs won!
Delighted to contribute to this review of the genetics of obesity, just out in @natmetabolism.nature.com, led by Amélie Bonnefond and Philippe Froguel. @chopresearch.bsky.social @penngenetics.bsky.social www.nature.com/articles/s42...
The genetics of obesity: aetiology, prevention and therapy - Nature Metabolism
This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesi...
nature.com
Delighted to contribute to this review of the genetics of obesity, just out in @natmetabolism.nature.com, led by Amélie Bonnefond and Philippe Froguel. @chopresearch.bsky.social @penngenetics.bsky.social www.nature.com/articles/s42...
The genetics of obesity: aetiology, prevention and therapy - Nature Metabolism
This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesi...
nature.com
Excited to finally share my recent preprint with @struangrant.bsky.social! www.biorxiv.org/content/10.6... We collected chromatin accessibility QTLs (caQTLs) from 10 different studies and observed that they are less depleted at selectively constrained genes compared to eQTLs. 👇👇👇
biorxiv.org
My lab is seeking to co-hire another postdoctoral fellow with the @shaonsengupta.bsky.social team. See details below! careers.chop.edu/us/en/job/10...
Research Postdoctoral Fellow - Grant & Sengupta Labs in Philadelphia, Pennsylvania, United States of America | Fellows, Students & Interns at Children’s Hospital of Philadelphia
Apply for Research Postdoctoral Fellow - Grant & Sengupta Labs job with Children’s Hospital of Philadelphia in Philadelphia, Pennsylvania, United States of America. Fellows, Students & Interns at Chil...
careers.chop.edu
A true honor speaking at the 'Festschrift' for my PhD supervisor from many years back. Best wishes to Stuart Ralston!
20 years ago today we first reported the TCF7L2 association with type 2 diabetes @natgenet.nature.com. Much to still figure out for this locus.... www.nature.com/articles/ng1...
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes - Nature Genetics
Nature Genetics - Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
nature.com
Delighted to contribute to this work led by Kyla Mace and @kayserlab.bsky.social: "Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2". @penngenetics.bsky.social @chopresearch.bsky.social www.nature.com/articles/s41...
Delighted to contribute. "Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk". @alessandrachesi.bsky.social @lisanwang.bsky.social rdcu.be/eXOb5
Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk
npj Dementia - Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk
rdcu.be
Congratulations to @khanhtrang.bsky.social. Delighted to contribute to this V2G across ~60 cell types & 15 autoimmune GWAS reports. @chopresearch.bsky.social @penngenetics.bsky.social
Andrew Wells@adwellspenn.bsky.social · 8mo agoCongratulations to lead authors Trang, Sharma & Cook on our new Genome Biology study with the Grant, Romberg & Levings labs. V2G across ~60 cell types & 15 autoimmune GWAS link.springer.com/article/10.1...
Thank you for sharing! It's members like you that demonstrate the quality of the programs that ASBMR offers. We hope people will take advantage of the opportunity to work with the best and brightest in bone and mineral research! 🦴
An outline of our recent bone 🦴 papers - with @j-a-mitchell.bsky.social and Babette Zemel. @chopresearch.bsky.social @penngenetics.bsky.social www.chop.edu/preview-link...
Children’s Hospital of Philadelphia Researchers Identify Genetic Factors Influencing Bone Density in Pediatric Patients
Understanding the causal gene was related to the dynamic between osteoblasts, which form new bone tissue, and osteoclasts, which break down old bone tissue. When children are growing, osteoblasts are far more active to help achieve proper bone growth.
chop.edu
As an ASBMR Ambassador, I invite you to check out the ASBMR @asbmr.bsky.social 2026 Student Cohort Program www.asbmr.org/student-cohort. The application deadline has been extended to November 28, 2025.
ASBMR Student Cohort Program
A new cohort program designed for undergraduate, graduate, and medical professional students involved in the bone, mineral, and musculoskeletal field. This cohort program provides accepted applicants
asbmr.org
As an ASBMR Ambassador, I invite you to check out the ASBMR @asbmr.bsky.social 2026 Student Cohort Program www.asbmr.org/student-cohort. The application deadline has been extended to November 28, 2025.
ASBMR Student Cohort Program
A new cohort program designed for undergraduate, graduate, and medical professional students involved in the bone, mineral, and musculoskeletal field. This cohort program provides accepted applicants
asbmr.org
@shaonsengupta.bsky.social and I are still hiring! Please DM us if interested www.nature.com/naturecareer...
Post Doctoral Research Fellow – Circadian Biology and Genomics - Philadelphia, Pennsylvania (US) job with Children's Hospital of Philadelphia | 12846607
A postdoctoral fellow is needed to join a strong team involved in spanning both dry and wet lab approaches.
nature.com
I'll again be at the #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 1.30-2.30pm today - come on by!
Struan Grant@struangrant.bsky.social · 10mo agoCheck out #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 Exhibit Level Halls A-B, Nonprofit and Advocacy Pavilion Tuesday, October 15 - Thursday, October 17
Come see Matt Pahl (@pahlmc.bsky.social) present at the #ASHG25 Session on Predicted Effector Genes. Here are the details for the session: Learn about the current predicted effector gene landscape 11:45AM-1:15PM ET Room 259A
Struan Grant@struangrant.bsky.social · 10mo agoOur #ASHG25 platform activities: Vrathasha Vrathasha: 3D genomics & glaucoma. 206AB, W 10.45-11 Winter Bruner: MPRA & childhood obesity. 205ABC, T 11-11.15 Matt Pahl: Ancillary Session, Predicted Effector Genes. 259A, F 1.45-1.15 Struan Grant chairs Metabolic Matrix session. 253ABC, S 10-11
I'll again be at the #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 3.30-4.30pm today - come on by!
Struan Grant@struangrant.bsky.social · 10mo agoCheck out #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 Exhibit Level Halls A-B, Nonprofit and Advocacy Pavilion Tuesday, October 15 - Thursday, October 17
Come see Winter Bruner, PhD today: "A comprehensive MPRA of both trans-ancestral genome-wide and suggestively-associated childhood obesity loci implicates a role for CBLN4 in microglia". Room 205ABC Thurs 11.00-11.15 Key contribution from Molly Ridler
Struan Grant@struangrant.bsky.social · 10mo agoOur #ASHG25 platform activities: Vrathasha Vrathasha: 3D genomics & glaucoma. 206AB, W 10.45-11 Winter Bruner: MPRA & childhood obesity. 205ABC, T 11-11.15 Matt Pahl: Ancillary Session, Predicted Effector Genes. 259A, F 1.45-1.15 Struan Grant chairs Metabolic Matrix session. 253ABC, S 10-11
I'll be at the #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 3.30-4.30pm today - come on by!
Struan Grant@struangrant.bsky.social · 10mo agoCheck out #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 Exhibit Level Halls A-B, Nonprofit and Advocacy Pavilion Tuesday, October 15 - Thursday, October 17
Check out #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 Exhibit Level Halls A-B, Nonprofit and Advocacy Pavilion Tuesday, October 15 - Thursday, October 17
