🔬 3ᵉ Symposium en Sciences de la Vie – Appel à communications ouvert ! Un rendez-vous incontournable pour présenter vos travaux et échanger avec des chercheurs expérimentés. 👉 Pour soumettre un résumé (Date limite : 3 avril) et vous inscrire, rendez-vous igdr-phd-symp26.sciencesconf.org?lang=en

I am happy to share our latest publication. In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.

Cell Reports@cp-cellreports.bsky.social · 6mo ago

A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1

Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells. www.nature.com/articles/s41...

Filament formation and NAD processing by noncanonical human FAM118 sirtuins - Nature Structural & Molecular Biology

Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that FAM118A/B processing of NAD involves head-to-tail filament...

nature.com

A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1. https://www.biorxiv.org/content/10.1101/2025.10.08.681224v1

#JEOL CRYO ARM™ 200 #CryoEM installed at the Institute Genetics & Development of Rennes. First installation of this type of instrument in France and incorporates the latest technologies in cryo contrast enhancement and dual-axis #tomography. We wish IGDR success with their future research projects.