Group Leader Career Development Fellowships - Dunn School

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

path.ox.ac.uk

Emma Slack and Kevin Foster elected members of EMBO - Dunn School

Both researchers are leaders in the rapidly growing field of the human gut microbiome.

path.ox.ac.uk

Two Dunn School researchers awarded 2026 Lister Prize

Many congratulations to Anjali Hinch and Girish Mali in the Sir William Dunn School of Pathology for this prestigious honour, recognising researchers in the early years of establishing their groups.

medsci.ox.ac.uk

Dunn School postdocs start new PI positions - Dunn School

Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

path.ox.ac.uk

Widespread DNA off-targeting confounds RNA chromatin occupancy studies - Nature Biotechnology

Many long noncoding RNA–DNA binding peaks detected using common assays arise from technical artifacts.

nature.com

biorxiv.org

PARP1-specific inhibitor displays PARP1-detrapping activity

Schützenhofer et al. show that expression of catalytically impaired PARP1 mutants is toxic to cells, which can be overcome by treatment with saruparib, a PARP1-specific inhibitor that displays a pro-r...

cell.com

PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly

The orphan PARP, PARP4, is shown to play a critical role in the apoptotic response to unresolved DNA interstrand cross-links.

science.org

Assembly of two functionally-distinct protein import complexes in the outer membrane of plant chloroplasts - Nature Communications

Chloroplasts import thousands of nucleus-encoded proteins via multiprotein translocons. The authors elucidate the assembly and molecular architecture of the outer-membrane TOC translocon (the import “...

nature.com

Specificity and recognition of the ADP-ribosyl-ubiquitin modification in the DNA damage response

Recent studies have shown that ADP-ribose modifications can be further modified by ubiquitin (ADPr-Ub), but there are still major gaps in our knowledge around this modification and its role in the DNA damage response. This study biochemically characterises the amino acid specificity for ADPr-Ub production and its recognition by E3 ubiquitin ligases.

journals.plos.org

FEBS Press

Sorbitol-induced hyperosmotic stress rapidly induces reversible mono(ADP-ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 depend...

febs.onlinelibrary.wiley.com

Reversible RNA ADP-ribosylation on uracil bases

Abstract. ADP-ribosylation is a conserved modification that uses NAD+ as a co-substrate to regulate essential cellular processes, such as genome stability

academic.oup.com

Structure, function, regulation, evolution, and therapeutic implications of PARP14

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

Histidine and tyrosine residues are targets for SIRT6 ADP-ribosylation activity

Abstract. SIRT6, a highly conserved member of the sirtuin family, plays a critical role in diverse cellular processes, including gene regulation, DNA damag

royalsocietypublishing.org

mdpi.com

The PARG frontier: mechanisms of PAR turnover and opportunities in precision oncology

ADP-ribosylation is a versatile post-translational modification that governs fundamental processes, including DNA repair, transcription, and stress ad…

sciencedirect.com

pubs.acs.org

Synthesis of Adenosine Diphosphate Ribose Histidine

Adenosine diphosphate ribosylated histidine (His-ADPr) is a vital signaling molecule for the bacterial immune system, the antiphage system in particular. In this unique second messenger molecule, the distal nitrogen of the histidine side chain is ribosylated in a β fashion. Here, we describe the synthesis of this bacterial metabolite and its triazole isostere and evaluate the stability of His-ADPr to relevant ribosyl hydrolases.

pubs.acs.org

PARG regulates the proteasomal degradation of TARG1

ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteost…

sciencedirect.com

Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation | The EMBO Journal

imageimageDegradation mechanisms of transcriptionally active aryl hydrocarbon receptor (AHR) are unclear. This work reveals that PARP7 ADP-ribosylates itself and ligand-bound AHR, creating a recogniti...

embopress.org

Filament formation and NAD processing by noncanonical human FAM118 sirtuins

Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...

rdcu.be

Filament formation and NAD processing by noncanonical human FAM118 sirtuins - Nature Structural & Molecular Biology

Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that FAM118A/B processing of NAD involves head-to-tail filament...

nature.com

Histone PARylation factor 1: a review of its role in the DNA damage response

Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted

academic.oup.com