Max Jordan
@maxljordan.bsky.social
Postdoc studying NLRs in Bacteria at the John Innes Centre
It was great to speak about our recent work on NLRs in Streptomyces at BacNet this week! An extremely friendly meeting packed with great science, and the location isn't too bad either!
Ákos T Kovács@evolvedbiofilm.bsky.social · 5d agoMax Jordan @maxljordan.bsky.social (from @s-lab.bsky.social lab) on autoactivation of an NLR-related transcriptional regulator enables characterisation of downstream signalling that activates Streptomyces antibiotic production #EMBOBacNet
Really cool work from @maxljordan.bsky.social @s-lab.bsky.social out on bioRXiv today! Find out more about how engineering NLRs in bacteria can enhance the production of antibiotics and anti-cancer drugs 👇🧬🧫
Max Jordan@maxljordan.bsky.social · 2w agoReally excited to share our new manuscript on how the #NLR protein #AfsR regulates #Streptomyces antibiotic production - and how we can use its similarity to plant NLR immune receptors to enhance this production! 📄🧵 (1/17) @johninnescentre.bsky.social www.biorxiv.org/content/10.6...
NLRs aren't just for immunity. Inspired by our colleagues working on plant NLRs, postdoc @maxljordan.bsky.social from my lab asked: Do bacterial NLR-type regulators found in antibiotic-producing #Streptomyces share a similar autoactivation switch? Turns out, yes! Read the full story and his 🧵👇
Max Jordan@maxljordan.bsky.social · 2w agoReally excited to share our new manuscript on how the #NLR protein #AfsR regulates #Streptomyces antibiotic production - and how we can use its similarity to plant NLR immune receptors to enhance this production! 📄🧵 (1/17) @johninnescentre.bsky.social www.biorxiv.org/content/10.6...
Really excited to share our new manuscript on how the #NLR protein #AfsR regulates #Streptomyces antibiotic production - and how we can use its similarity to plant NLR immune receptors to enhance this production! 📄🧵 (1/17) @johninnescentre.bsky.social www.biorxiv.org/content/10.6...
A conserved NLR activation switch governs global transcriptional control of antibiotic biosynthesis in Streptomyces
Nucleotide-binding and oligomerization domain-like receptors (NLRs) are conserved molecular switches that regulate innate immunity across diverse domains of life. While best known for their roles in i...
biorxiv.org