Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/45fpXCZ

Diverse bacterial pattern recognition receptors sense the core phage proteome - Nature

Systematic analysis of prokaryotic STAND NTPases — relatives of animal and plant immune receptors — uncovers diverse antiviral sensors that detect most of the core structural and replicative proteins of bacteriophages.

go.nature.com

We built a a self-dividing synthetic cell ! Check out this #CDlab preprint on BioRxiv: www.biorxiv.org/content/10.6... Great work by 1st author Charu Sharma who encoded dynaminA in a genome and expressed that in liposomes that then divide into daughter cells! Collaboration with Koenderink lab!

Our new preprint is out! We investigate chromosome organization in obligate mammalian symbionts and show that these bacteria maintain stable chromosome orientations while displaying conserved lifestyle-associated chromosome architectures across species. www.biorxiv.org/cgi/content/...

I just still cannot help myself from looking that these beautiful real-time dynamics videos from @anjbadri.bsky.social lab! thanks to all the authors from @joeloparo.bsky.social / @anjbadri.bsky.social and TJ Ha labs.

Miloš Tišma@tismaa.bsky.social · 2w ago

I'm happy to share the first paper from my postdoc work: www.biorxiv.org/content/10.6... How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one? We find that DNA topology is the gatekeeper !! 1/10

Together with @thanbichlerlab.bsky.social, we are looking for an ambitious PhD student to develop fluorescence imaging for anaerobic bacteria. Check out this and other positions that are announced as a part of the M4C Excellence cluster here: stellenangebote.uni-marburg.de/jobposting/2...

Out @cp-cellhostmicrobe.bsky.social, natural products meet bacterial immunity! We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages. Led by @hshomar.bsky.social & @mariegllm.bsky.social www.sciencedirect.com/science/arti...

A family of lanthipeptides with anti-phage function

Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some nat…

sciencedirect.com

A family of lanthipeptides with anti-phage function Discovery of 2,000+ lanthipeptide biosynthetic gene clusters with anti-phage potential. Lanthivirins inhibit phage replication by targeting phage proteins & interfering with phage DNA replication. www.cell.com/cell-host-mi...

A family of lanthipeptides with anti-phage function

Shomar, Guillaume, et al. report the genomics-driven discovery of a family of more than 2,000 lanthipeptide biosynthetic gene clusters with anti-phage potential. They experimentally demonstrate anti-p...

cell.com

New updates to AllTheBacteria - some super cool results and an amazing resource for the community

César de la Fuente@delafuentelab.bsky.social · 2w ago

Biology has plenty of data—the challenge is making it usable. AllTheBacteria transforms 2.44 million public bacterial and archaeal genomes into an open, uniformly processed, searchable, AI-ready resource. www.biorxiv.org/content/10.1...

Systematic identification of cell division proteins in haloarchaea and the discovery of a membrane anchor for the Z ring. www.biorxiv.org/content/10.6...

Systematic identification of cell division proteins in haloarchaea and the discovery of a membrane anchor for the Z ring

Most archaea rely on the tubulin-like protein FtsZ for division. In the last decade, several novel cell division proteins have been discovered in the model haloarchaeon Haloferax volcanii which contai...

biorxiv.org

research.pasteur.fr/en/call/mid-...

Mid-career Group Leader position in Chemistry for Health at Institut Pasteur, Paris - Research

Institut Pasteur and the CNRS are launching a joint call for a mid-career group leader position in Medicinal Chemistry and Chemistry for Health. We are looking for an experienced researcher (typically...

research.pasteur.fr

Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵

This was a wonderful collaborative effort between us at the Univeristy of Zurich, @ethz.ch and old friends @unituebingen.bsky.social and new friends @cbitoulouse.bsky.social @matthchavent.bsky.social

So excited to share our new preprint! 🎉🤩 Check it out to discover how we investigated the role and spatiotemporal dynamics of an essential Tad nanomachine during the lifecycle of our favorite bacterial predator, B.bacteriovorus 🦠 Many thanks to everyone who made this work possible!

Géraldine Laloux@lalouxlab.bsky.social · 4w ago

New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠

🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇

The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology

A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.

doi.org

Another collaborative paper from the @ilango-aravind.bsky.social & @heathmurraylab.bsky.social team, here focused on the essential DNA replication initiation protein DnaB in Bacillus subtilis. Credit to Aurélie Guyet, Fred Schramm and @winterhalterlab.bsky.social academic.oup.com/nar/article/...

Microbes that have the greatest genomic potential for secondary metabolism tend to be multicellular. Here, we show that signatures of ancestral BGC expansions within 3 bacterial phyla and 2 fungal lineages coincide with origins of complex multicellularity [1/12] 🧵 www.nature.com/articles/s41...

Complex multicellularity is linked with expanded specialized metabolite production in microorganisms - Nature Microbiology

The evolutionary emergence of complex multicellularity in bacteria and fungi, such as the ability for mycelial growth, is strongly associated with increased genomic carriage of biosynthetic machinery ...

nature.com

A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics www.nature.com/articles/s41...

A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics - Nature

In Streptomyces spp., a conserved biosynthetic gene megacluster produces an arsenal of distinct antimicrobials that converge on bacterial biotin biosynthesis as a naturally evolved combination therapy...

nature.com

Another chapter of my thesis is out! We asked whether we could pair proteome-wide AlphaFold screening with Tn-seq to identify biologically relevant protein-protein interactions. We identify ClcR (formerly YerH) as a component of the Rod complex in Gram-positive bacteria. www.pnas.org/doi/10.1073/...

A broadly conserved gram-positive lipoprotein regulates cell elongation | PNAS

The cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carr...

pnas.org

Deeply grateful to everyone who made this work possible, including @upenn.edu, @cbe-penn.bsky.social, @pennengineering.bsky.social, @pennmedcso.bsky.social, @pennmicro.bsky.social, and @sas.upenn.edu. www.nature.com/articles/s41...

Deep learning reveals antimicrobial peptides within prions - Nature Microbiology

Deep learning reveals that prion-related proteins contain hidden ‘prionin’ peptides with antibacterial activity, including two candidates that reduced infections in mice.

nature.com

VACANCY - Group Leader in Fundamental Biology of Legumes Closing date: 1 September 2026 Salary: competitive Contract: six-year tenure track or direct appointment, depending on experience Apply now: www.jic.ac.uk/vacancies/gr...

How do pathogens disarm plant immunity? We discovered a widespread strategy used by plant bacterial pathogens: they directly cleave a conserved immune signaling molecule produced by plant immune receptors. www.biorxiv.org/content/10.6...

How do human cells defend against viruses? @sgfern.bsky.social discovers that human immune proteins named ISGs target ancient features of replication shared between animal and bacterial viruses – opening analysis of human immunity to the power of bacterial genetics www.biorxiv.org/content/10.6...

Bacterial cell division protein FtsZ complexes with a phage protein to activate bacterial immunity @natmicrobiol.nature.com from Michael Laub & Abel Garcia-Pino www.nature.com/articles/s41...

Bacterial cell division protein FtsZ complexes with a phage protein to activate bacterial immunity - Nature Microbiology

The activation of an antiphage defence system relies on host factors targeted by phages, a mechanism analogous to the way that eukaryotic innate immune systems detect pathogen-induced perturbations of...

nature.com

Now finally published as a Version of Record: In @elife.bsky.social: Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis doi.org/10.7554/eLif...

Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis

Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min ...

doi.org

now published!!! @johninnescentre.bsky.social @leahmcphillips.bsky.social academic.oup.com/nar/article/...

Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems

Abstract. Low-copy-number plasmids often rely on dedicated maintenance mechanisms, such as partitioning systems, to ensure stable inheritance across genera

academic.oup.com

VACANCY - Are you looking for a new career opportunity? Come and join us as our Assistant Lab Manager, supporting the world‑class science delivered across our institute. www.jic.ac.uk/vacancies/as... Closing date - 17 June 2026 Salary - £36,540 - £40,600 per annum Contract - Permanent, full-time

We’re looking for a postdoc to identify polarity determining factors in bundle sheath cells of C4 grasses and their role in the carbon concentrating mechanism. @johninnescentre.bsky.social Applications close 15th June. Please check out the job ad below or get in touch! #PlantSciJobs

John Innes Centre@johninnescentre.bsky.social · 3mo ago

An exciting opportunity to join Dr Schreier's new group as a postdoctoral researcher is open for applications until 15 June 2026: www.jic.ac.uk/vacancies/po...

🛠️💉It's time for engineering contractile injection systems! @chipericson.bsky.social & @davidschaumann.bsky.social introduce programmable CIS - PROCIS, combining tail length control, non-native cargo loading, and cell retargeting all in one system! www.biorxiv.org/content/10.6... 🧵 1/5

Update on GeneFrame alternative for bacterial imaging. After discussion with us and others, SunJin lab have how launched a substitute for timelapse imaging in geneframes www.sunjinlab.com/product/ispa... Dimensions are very similar, price is reasonable ($105 for 250) #microsky

Séamus Holden 🔬🦠🧫@seamusholden.bsky.social · last yr.

Fellow bacterial cell biologists, message me if you use @thermofishersci.bsky.social Gene Frames for microscopy! Thermo are planning to discontinue these in September but have indicated they will look into this further. If I make list of labs using them Thermo might not kill the product Please RT🔬🦠