CRISPR HDR genome editing uses a repair template. But the @mccabelab.org in @epfl-brainmind.bsky.social found these templates sneak into the #Drosophila genome uninvited, corrupting downstream results. Their fix is a template design that makes stray insertions easy to catch: doi.org/10.1371/jour...

Minis, aka spontaneous synaptic neurotransmitter vesicle release, was long dismissed as noise. Our new 📄 using optical electrophysiology shows minis are not spontaneous at all. They're an independent release modality regulated by Unc-5 & critical for synapse preservation 👉 doi.org/10.64898/202...

New manuscript by Evelyne 👉 pBID2 series of standardized, optimized #Drosophila vectors enables parallel generation of Gal4, LexA & QF2 + UAS, LexOp & QUAS lines. 🆕 is QFG4, a QF–Gal4 hybrid, allowing Gal80-coordinated temporal control of independent UAS & QUAS transgenes doi.org/10.64898/202...

Weird results from CRISPR/Cas9 Homology Directed Repair (HDR) based genome editing? We show that frequently the HDR template vector becomes incorporated into the genome causing all sorts of problems. For #Drosophila, we develop a vector to detect these unwanted events www.biorxiv.org/cgi/content/...

Many congratulations to lab member Medha Raman for winning the EPFL final of MT180 - My Thesis in 180 seconds

Apply to now for an open PhD position working on motor neuroscience in our laboratory. We investigate motor system synapse and circuit function in #Drosophila and apply our models to understand human motor system dysfunction during ageing and in the disorders #ALS, #FTD and #SMA.

EPFL Brain Mind Institute@epfl-brainmind.bsky.social · last yr.

Applications for PhD positions in neuroscience at EPFL are now being accepted www.epfl.ch/education/ph.... Join the exciting research programs of the @trackingskills.bsky.social, @trackingactions.bsky.social, @mccabelab.org, Carl Petersen or Pavan Ramdya groups. Deadline April 15 2025 - Apply today!

Thank you to Target ALS for highlighting the work on #ALS in our laboratory together with Bernard Schneider and Sabine Liebscher. We are very grateful for your funding and unflagging support - www.targetals.org/2025/03/04/i...

Unveiling the Path to ALS Therapies: A Journey from Flies to Humans - Target ALS

Exploration of ALS biology has found new momentum through innovative research led by Brian McCabe, Bernard Schneider, and Sabine Liebscher. Their work, funded by Target ALS, sheds light on novel thera...

targetals.org