Always nice to see some of our work featured in the PDB's Molecule of the Month: pdb101.rcsb.org/motm/319
PDB101: Molecule of the Month: Hantavirus
Family of rodent-borne viruses that can cause severe illness in humans
pdb101.rcsb.org
Jason McLellan
@mclellanlab.bsky.social
Structural virology / Structure-based vaccine design mclellanlab.org Professor of Molecular Biosciences The University of Texas at Austin Opinions are my own and not the views of my employer
I enjoyed this article. Interesting statistical comparisons. www.expectinggoals.com/p/messi-rona...
Why Messi keeps thriving as Ronaldo fades: The GOAT's always been the best
I'm not proud, or tired
expectinggoals.com
Had a great time at the match watching Messi score 2!!
#PostdocRecruiting: My group at the University of Texas at Austin is recruiting a Postdoc in virology and structural biology. Please see more details here: utaustin.wd1.myworkdayjobs.com/UTstaff/job/... Informal inquiries are encouraged, and see more lab info here: zunlongke-lab.org
Postdoctoral Fellow
Job Posting Title: Postdoctoral Fellow ---- Hiring Department: Molecular Biosciences ---- Position Open To: All Applicants ---- Weekly Scheduled Hours: 40 ---- FLSA Status: Exempt ---- Earliest Start ...
utaustin.wd1.myworkdayjobs.com
Our fourth installment on prefusion herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... Working with Ivelin Georgiev's group, we isolated and characterized prefusion-specific HSV gB antibodies from humans!
Our third installment on prefusion stabilization of herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... A great collaboration with colleagues at Merck. Our prefusion HSV-2 gB protein adopts a more closed conformation than has been observed for HSV-1 gB in recent papers.
Excited for Adam Klivans and my other colleagues at UT working in the AI space!
Texas Science@texasscience.bsky.social · 9mo agoAlready among the most powerful artificial intelligence hubs in academia, the UT Center for Generative AI is keeping its foot on the gas. “It’s exciting to accelerate discovery and to create more opportunities for our researchers to push the boundaries of what’s possible.”
Happy Halloween! My daughter is dressed as Hornet from Silksong, the game I've spent 60 hours playing the past two months
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
Texas Science@texasscience.bsky.social · 10mo agoUT Austin has a new “genius grant” recipient! Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation. #TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social cns.utexas.edu/news/accolad...
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
Getting ready for the Viruses and Cells GRC in Castelldefels
New exhibit at the National Inventors Hall of Fame 👀
"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q
H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics (Gift Article)
Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.
nyti.ms
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV. @mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine cns.utexas.edu/news/announc...
UT Vaccine Scientist Will Be Inducted Into National Inventors Hall of Fame
McLellan, who will be inducted in Washington, D.C. on May 8, is among the youngest new inductees in hall of fame history.
cns.utexas.edu
PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at jimhurley@berkeley.edu. Repost appreciated.
Congratulations Elizabeth! Great collaborative effort with our colleagues Kartik Chandran, Andrew Herbert, Stephanie Monticelli and more!
Register now to hear some cool vaccine science! I'll be speaking at this conference, so come hang out!
My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝
Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science!...