As an academic, I have decided to pre-empt AI taking my job, so I am going to take ITS job! I am going to start hallucinating, lying to my students, and drinking 700,000 litres of water
Jim Hurley
@jimhurley.bsky.social
membranes, autophagy, lysosomes, cryo-EM and -ET, Parkinson's
📣 Don’t miss our upcoming @mito911.bsky.social #webinar featuring Thomas Melia, PhD, from Yale School of Medicine. 👇 Reserve your spot using the link below. 📅 April 21 ⏰ 11:00 AM ET RSVP: bit.ly/4sfBDiF
The application deadline for the 20th FEBS/EMBO Spetses meeting is extended to the 15th March! Please sign up at the link below, or encourage your PhDs and postdocs to come along for what is certain to be a wonderful week!
CALLING PHDs AND POSTDOCS! Apply for the 20th FEBS/EMBO summer school on Membranes lipids & proteins in organelle biogenesis! Spend a glorious week with leaders in the field on the beautiful island of Spetses in Greece this May. Registration: spetses2026.sites.uu.nl @embo.org @febspress.bsky.social
📢 New #preprint from CRN Team Hurley! The team uncovers the mechanism of ATG2A-mediated lipid transport 🧪 Structural modeling and simulations show that N-terminal helices gate lipid transfer, and a designed mutant transfers lipids three times faster in vitro. 🔗 bit.ly/3ZVAxw6
At #BPS2026? 🧬 Come talk structural biology & mTORC1 signaling! I'll be at Poster B220 this Tuesday, 2:45–3:45 PM. I’m also building the Cui Lab at CU Anschutz and looking for postdocs/students interested in Cryo-EM and ML. Let's chat! 🧪🏔️ #Biophysics #CryoEM #StructuralBiology
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid
Seen in the neighborhood: On integrating theory and practice.
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
biorxiv.org
Alpha Fold predictions: trust but verify (original "доверяй, но проверяй").
New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs with the generous support of @asapresearch.parkinsonsroadmap.org doi.org/10.1101/2025...
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
The ULK1 complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) act together to initiate autophagy. Human ULK1C consists of ULK1 itself, FIP200, and the HORMA domain het...
doi.org
Membrane dynamics, repair and disease Keystone symposium this February in Colorado. The real, true, final abstract deadline is tonight so the organizers can start picking the short talks tomorrow! www.keystonesymposia.org/conferences/...
Membrane Dynamics, Repair and Disease | Keystone Symposia
Join us at the Keystone Symposia on Membrane Dynamics, Repair and Disease, February 2026, in Keystone, with field leaders!
keystonesymposia.org
Collaborative. Creative. Impactful. Come join us in Ann Arbor! For more information and application link see jobs.sciencecareers.org/job/675674/f...
Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
2026 Autophagy in Stress, Development and Disease Conference GRC
The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.
grc.org
Early-career scientists - last call! ⏰ Submit your short talk abstract or scholarship app by Oct 8 (11:59 pm MDT) for Autophagy: Mechanisms to Therapy. Join @annesimonsen.bsky.social, Dan Baird & others! 🔗 keysym.us/KSAutophagy26 🎥 youtu.be/4Y6YvL-unAM #KSAutophagy26 #autophagy #mitophagy
KSQA: Dr. Dan Baird (Autophagy)
YouTube video by KeystoneSymposia
youtu.be
📣 Don't miss out on the upcoming mito911 #webinar featuring Karin Reinisch, PhD, from the Yale School of Medicine. 👇 Reserve your spot using the link below. 📅 October 20 ⏰ 11:00 AM ET RSVP: bit.ly/4gPqCjo
Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.
Finally in @nature.com 🎉 We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism. www.nature.com/articles/s41...
Structural basis for mTORC1 activation on the lysosomal membrane - Nature
Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...
nature.com
RFK Jr. rolled out that old chestnut again about how healthy Americans were in the 60’s, so here’s a fact check. In 1965: -42% of American adults smoked; it’s 11% now. -The infant morality rate was 24.7/1000; it’s 5.6/1000 now. -Overall life expectancy was 70 years; it's about 77 years now.
📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin. 👇 Reserve your spot using the link below. 📅 September 8 ⏰ 11:00 AM EST RSVP: bit.ly/4mUJeAc
🧪 And House appropriators say: no cuts to NIH budget! House subcommittee version just came out (link below). Holds NIH flat at $48 billion. To be clear: this is far from over. But a good sign that science still matters across both sides of aisle. YOUR VOICE MATTERS!!
appropriations.house.gov
🧪 Senate appropriators say: NIH's budget gets a... boost! Rather than 40% cut, NIH gets a $400M *increase* in the Senate committee bill for FY26 (about +1%). "Congress has your back," said @murray.senate.gov. ADVOCACY MATTERS! There's still a long road (esp in the House), so keep up pressure.
BREAKING: Big moment as CDC staff stage a mass walkout. They have lined the street outside its HQ to greet and salute the four top officials who have resigned in protest at RFK Jr’s attack on the agency’s science base. (🎥 AP)
BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍
🧪 The University of Basel is setting up a new endowed professorship in #ClimateBiophysics at the @biozentrum.unibas.ch, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research @unibas.ch. www.biozentrum.unibas.ch/news/detail/...
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Open faculty position! We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
We're Hiring! Assistant Professor of Molecular Therapeutics in MCB. Learn more and apply online: aprecruit.berkeley.edu/JPF05098
So happy to see @doroteaartscience.bsky.social 's art on the cover!
🏖️Our August issue's out! Cover: Flexibility of #autophagy initiation 👉🏼Review on #metabolism in #embryogenesis #devbio 👉🏼Review on #DNArepair 🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more! www.nature.com/ncb/volumes/...
New research reports the identification of a Mitophagic Stress Response ("MitoSR" - mmm, catchy!) activated by mitochondrial damage in neurons & operating in parallel to canonical Pink1/Parkin-dependent mitophagy www.nature.com/articles/s41...
Want to share your work at the premiere meeting of the minds between basic membrane biology and therapeutics? Short talk deadline is coming up Oct. 8, 2025. www.keystonesymposia.org/conferences/...