Our flagship conference celebrating everything centrosomes and cilia returns this year and it promises to be another exceptional scientific event in the beautiful city of Lausanne, 1–4 September. 👉 Abstract submission+registration deadline 1 June Don’t miss the opportunity to share your research 🤩

Very happy to see our paper “Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization” featured in the Nature Communications Editors’ Highlights (Cancer). Many thanks to the editors for highlighting our work. www.nature.com/ncomms/edito...

New in @natcomms.nature.com, OIST researchers describe how cancer cells lose their sense of time to evade stress responses – revealing new insights that could shape anti-cancer treatments. www.oist.jp/news-center/... Or read the full paper at www.doi.org/10.1038/s41467-025-66341-3

Cancer loses its sense of time to avoid stress responses

New insights into mitotic stopwatch show how cancer escapes cell death and cell division arrest.

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Missense mutations in the C-terminus region of USP28 discovered to disrupt 53BP1 interaction and p53 stabilization @meitinger.bsky.social doi.org/10.1038/s414...

Our study on the mitotic stopwatch has been published. We demonstrate that USP28 interacts with 53BP1 to stabilize p53 and show that cancer cells frequently harbor mutations that impair stopwatch assembly, thereby suppressing the mitotic stress response. rdcu.be/eTPU2

Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization

Nature Communications - USP28 and 53BP1 proteins form a complex to stabilise the tumour suppressor p53, which is required to protect cells from mitotic stress and subsequent genome instability....

rdcu.be

Congratulations to Hamzah for receiving the EMBO Molecular Medicine Poster Prize at #MBSJ2026. Well deserved! www.aeplan.jp/mbsj2025/en-...

We’re recruiting a Postdoctoral Researcher at OIST (Okinawa, Japan) to explore how mitotic stress shapes aging. If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you. More info: www.oist.jp/careers/post... Website: www.oist.jp/research/res...

Cell Proliferation and Gene Editing Unit

Every day, millions of cells divide to sustain essential tissue functions. Errors in this process can lead to developmental disorders or cancer. Our research focuses on the molecular mechanisms of cel...

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The mitotic stopwatch synergizes with mild p53 activation to halt cell proliferation https://www.biorxiv.org/content/10.64898/2025.12.02.691971v1

If you’re interested in aneuploidy, mark your calendar! The FASEB SRC on the Consequences of Aneuploidy will be held Sept 28 - Oct 1, 2026 in Melbourne, Florida. Many speaking slots are reserved for early-career researchers. Please help spread the word! events.faseb.org/event/Aneupl...

Join us for the #CellDivision2026 meeting in Okinawa. Abstract Submission Deadline: Nov 3. www.oist.jp/conference/c...

Join us for the Cell Division Meeting in the Pacific Island setting of Okinawa. Hosted at OIST, this symposium brings together leading researchers to explore emerging roles of the cell cycle in development, cancer, and aging. Registration now open: www.oist.jp/conference/c...

The OIST Graduate School has opened a Special PhD Admissions Portal for students currently enrolled in, or accepted to, universities in the U.S. #PhDprogram www.oist.jp/admissions/s...

Special Application Deadline for Students Accepted or Studying in the United States

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Excited to share our new preprint on @biorxivpreprint! We show that USP28 mutations found in cancer block its interaction with 53BP1, disrupting p53 stabilization. Check out the full story... @Midori_RuruOta www.biorxiv.org/content/10.1...

Check out our review on "PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential". Everything you need to know about centriole duplication, mitotic stopwatch and TRIM37-mediated cancer-specific vulnerabilities. onlinelibrary.wiley.com/doi/10.1002/...

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Centrosomes catalyze the assembly of a microtubule-based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo-Like Kinase 4 ...

onlinelibrary.wiley.com

We wish you Happy Holidays from Okinawa!

A prolonged mitosis is characteristic of defects that drive genome instability. What are the underlying causes and broader implications of prolonged mitosis? Check out our review... authors.elsevier.com/sd/article/S...

Interested in Base Editing and Genetic Screening? Check out our method chapter: link.springer.com/protocol/10.... Esther Ng did an excellent job developing these methods in our lab. The constructs will soon be available on @addgene.bsky.social Many thanks to OIST for supporting open access!

Genetic Engineering and Screening Using Base Editing and Inducible Gene Knockout

Genetic engineering and screening in human cells are powerful techniques for the precise and comprehensive identification and analysis of gene and protein domain functions. Genome-wide knockout screen...

link.springer.com

@MBSJ 2024 in Fukuoka