Very happy to see our study on the development of an in vivo single-cell ribosome profiling strategy for the epidermis now online at @cp-molcell.bsky.social. Fantastic work by @claradure.bsky.social and all co-authors involved. www.cell.com/molecular-ce...

In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging

In vivo single-cell ribosome profiling reveals cell-type-specific translational landscapes across the epidermis and uncovers selective reprogramming of AP-1 subunit translation in aged stem cells, lin...

cell.com

Check out the latest work from our lab! Amazing job @dadita.bsky.social 👏🏻👏🏻💯

David Taborsky@dadita.bsky.social · last yr.

How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!

PhDone 🥳🎓 The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A

Sendoel Lab@sendoellab.bsky.social · last yr.

The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!

Preprint by the Sendoel Lab ( @sendoellab.bsky.social ) with first author Merve Yigit ( @merveyigit.bsky.social‬ "The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control" @biorxivpreprint.bsky.social‬ buff.ly/hP9Iani ‪@anupamd.bsky.social‬

I’m thrilled to share my very first first-author preprint and our lab’s latest work💫 We discovered a novel role for eIF2A in ribosome-associated quality control (RQC), challenging decades-old assumptions about its enigmatic function in translation initiation. Check it out to learn more! ⭐️ #RNA

Sendoel Lab@sendoellab.bsky.social · last yr.

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x www.biorxiv.org/content/10.1...

Oh, the weather outside is frightful But the paper submission is so delightful And since we've no results yet Let it pipette, let it pipette, let it pipette

Clara Duré@claradure.bsky.social · 2y ago

It‘s beginning to look a lot like Christmas🎄 when you suddenly need two additional pairs of helping hands 🐙 🧪 @merveyigit.bsky.social @fabiolavaldiviaf.bsky.social

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6 www.biorxiv.org/content/10.1...