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MetaStem

@metastem.bsky.social

Centre of Excellence in Stem Cell Metabolism at University of Helsinki. Funded by Research Council of Finland, Suomen Akatemia 2018-2025 www.helsinki.fi/metastem @MetaStem_Center on X

23 Posts74 Follower115 Folgt
MetaStem@metastem.bsky.social · 10mo ago

News from our CoE by @htyynismaa.bsky.social and Ruben Torregrosa Munumer labs. Mitochondrial ATP synthase deficiency results in Metabolic trade-offs and vulnerabilities in stem cell derived motor neurons www.nature.com/articles/s42... @helsinki.fi @stemmprogram.bsky.social

Metabolic costs and trade-offs of hypermetabolism in human motor neurons with ATP synthase deficiency - Communications Biology

Hypermetabolism results in the redistribution of acetyl-CoA usage, reduced histone acetylation, and potential vulnerabilities of motor neurons via altered maintenance of acetylcholine

nature.com

MetaStem@metastem.bsky.social · last yr.

News from our CoE by @katajistolab.bsky.social @simonsterson.bsky.social found that intestinal stem cells with old mitochondria make Paneth cells faster due to higher aKG levels and aKG improves regeneration in old animals by renewal of Paneth cells. www.nature.com/articles/s42... @helsinki.fi

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

nature.com

MetaStem@metastem.bsky.social · last yr.

News from our CoE by @otonkoskit.bsky.social lab, Eliisa Vähäkangas et al show that upon engraftment into mice stem cell derived pancreatic islets become insensitive to pyruvate, correlating with down regulation of the pyruvate/lactate transporter MCT1. link.springer.com/article/10.1... @helsinki.fi

Stem-cell-derived beta cells mature metabolically upon murine engraftment - Diabetologia

Aims/hypothesis The use of stem-cell-derived islets (SC-islets) as a source for cell-based therapy of type 1 diabetes shows great potential. However, SC-islets have a metabolically immature phenotype ...

link.springer.com

KatajistoLab@katajistolab.bsky.social · last yr.

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

nature.com

MetaStem@metastem.bsky.social · last yr.

News from our CoE by @htyynismaa.bsky.social group characterize the role of mitochondrial intermembrane space protein CHCHD10 in metabolism and spinal muscular atrophy Jokela type (SMAJ) actaneurocomms.biomedcentral.com/articles/10.... Congratulations Sandra! @helsinki.fi @stemmprogram.bsky.social

Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism - Acta Neuropathologica Communications

Dominant defects in CHCHD10, a mitochondrial intermembrane space protein, lead to a range of neurological and muscle disease phenotypes including amyotrophic lateral sclerosis. Many patients present w...

actaneurocomms.biomedcentral.com

@pekka-katajisto.bsky.social · last yr.

Hien’s peroxisome story is out! Amazing effort starting from description of a new phenomenon, building in vivo tools, and describing how sub-cellular localization of metabolic activities can guide stem cell fate. Congrats Hien and thank you to the great collaborators!

KatajistoLab@katajistolab.bsky.social · last yr.

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com A thread 🧵 1/9

MetaStem@metastem.bsky.social · last yr.

A new study from our CoE finds that stem cells can control whether they self-renew or differentiate by localizing certain metabolic reactions differently www.helsinki.fi/en/faculty-b... @helsinki.fi @helsinki-biotech.bsky.social #stemcell #metabolism #peroxisome

Organelle age guides tissue renewal through subcellular compartmentalization of metabolism | Faculty of Biological and Environmental Sciences | University of Helsinki

A new study sheds light on the mechanisms that regulate how our tissues develop and are constantly renewed to keep up their function. In the future, these results might contribute to the understanding...

helsinki.fi

MetaStem@metastem.bsky.social · last yr.

News for our CoE by @katajistolab.bsky.social show how tissue stem cells can metabolically regulate tissue renewal and differentiation by providing daughter cells with peroxisomes of different age and metabolic properties nature.com/articles/s41... @helsinki.fi @helsinki-biotech.bsky.social

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

nature.com

KatajistoLab@katajistolab.bsky.social · last yr.

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com A thread 🧵 1/9

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

nature.com

Rafa Najumudeen@rafabolism.bsky.social · last yr.

Glad to be highlighted as FutureLeaders in Cancer research by Cancer Grand Challenges @cancergrand.bsky.social. Thank you! @fimm-uh.bsky.social, @helsinki-biotech.bsky.social, @metastem.bsky.social, @cruk-si.bsky.social. features.cancerresearchuk.org/cancergrandc...

DFS 0161 CGC Discover mag 2024 — Future Leaders

A year of scientific creativity

features.cancerresearchuk.org

Rebecca Eccles@rebeccaeccles.bsky.social · last yr.

The 24/25 edition of @cancergrand.bsky.social progress magazine is now live! Including: 👉key advances from our funded teams 👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease 👉our 7 new challenges features.cancerresearchuk.org/cancergrandc...

MetaStem@metastem.bsky.social · last yr.

MetaStem PhD defence 🎩 April 25th at 12 Pooja Manjunath from @htyynismaa.bsky.social lab will defend her thesis Preserving Mitochondrial Proteostasis and Structure-The Roles of Mitochondrial Co-Chaperones GRPEL1, GRPEL2, and Small Protein NERCLIN in Porthania PIII. Opponent Prof Kostas Tokatlidis 👏

MetaStem@metastem.bsky.social · 2y ago

News from our CoE by @katajistolab.bsky.social @sharifiqbal.bsky.social shed light on how the intestinal epithelium is repaired after injury, with implications for aging and chemotherapy-induced damage www.sciencedirect.com/science/arti... @helsinki.fi @helsinki-biotech.bsky.social Congratulations 🎉

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin

Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

sciencedirect.com

KatajistoLab@katajistolab.bsky.social · 2y ago

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin

Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

sciencedirect.com