Intestinal stem cells optimise receptiveness to signals within the niche by orientating Golgi apparatus laterally towards Paneth cells 📹 Ilya Belevich et al Sandra Scharaw @katajistolab.bsky.social @helsinki.fi in @natcomms.nature.com ➡️ bpod.org.uk/archive/2026...

Happy to see this fantastic paper finally out. Started as a PostDoc in our lab and finished in her own lab at @mpi-cbg.de talented Sandra Scharaw show how intestinal stem cells optimize niche signal reception by multiple lateral Golgi stacks facing Paneth cells www.nature.com/articles/s41...

Golgi organization regulates stem cell function in the small intestine - Nature Communications

Here the authors show that intestinal stem cells reorganize their Golgi apparatus to improve the delivery of receptors that receive signals from nearby support cells. This adaptation promotes efficien...

nature.com

Excited to Kick-off our 8-year Centre of Excellence focusing on Metabolic Integration. MetaScale brings together the groups of @pekka-katajisto.bsky.social @awartiovaara.bsky.social Elina Ikonen, Ville Hietakangas @emmihelle.bsky.social @rafabolism.bsky.social and @diegobalboa.bsky.social

Welcome to the PhD defense of @hienbui.bsky.social Age-selective segregation of organelles in asymmetric stem cell division, on Fri 7 Nov at 1 pm, Biocenter 2, 2041. Opponent Prof Carien Niessen, University of Cologne @helsinki.fi @hilife-helsinki.bsky.social #publicdefense #phddefense

Suomen Akatemia on valinnut 11 uutta tutkimuksen huippuyksikköä ohjelmakaudelle 2026–2033. Niistä viittä johdetaan Helsingin yliopistosta. Yhteensä yliopiston tutkijat ovat mukana kahdeksassa uudessa huippuyksikössä. www.helsinki.fi/fi/uutiset/y...

Helsingin yliopisto johtaa viittä uutta tutkimuksen huippuyksikköä | Helsingin yliopisto

Suomen Akatemia on valinnut 11 uutta tutkimuksen huippuyksikköä ohjelmakaudelle 2026–2033. Niistä viittä johdetaan Helsingin yliopistosta, ja yhteensä yliopiston tutkijat ovat mukana kahdeksassa uudes...

helsinki.fi

Still time today to sign up and submit an abstract for this excellent symposium

MetaStem@metastem.bsky.social · last yr.

Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social

On Tue Oct 14th @simonsterson.bsky.social will defend his thesis Age-selective organellar metabolism in tissue stem cell function, at 1 pm in Biocenter 2 2041, Viikki. Excited to have Jared Rutter @rutterlab.bsky.social as the opponent 🎩⚔️ Welcome! @metastem.bsky.social @hilife-helsinki.bsky.social

Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇

MetaStem@metastem.bsky.social · last yr.

Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social

Welcome to the Stem Cell Seminar next week Friday Oct 3rd at 9-11, ☕️🍪 at 8:30. Exciting science on embryo development, ECM, cancer and stem cells by Juha Kere and @johannaienglund.bsky.social labs. See you there! @hilife-helsinki.bsky.social @helsinki-biotech.bsky.social @stemmprogram.bsky.social

#CFM_MolCellAging: The third session will deal with the regulation of aging processes, with talks by @pekka-katajisto.bsky.social  @metastem.bsky.social  @helsinki.fi and Salvador Aznar @irbbarcelona.org   Registration: http://bit.ly/4kOyYch   🤝With support of @caixaresearch.bsky.social

Pekka Katajisto @katajistolab.bsky.social introducing Nobel laureate Shinya Yamanaka who will talk about 2 of my favorite topics: sciences and marathons

Also read the research briefing on our latest paper in @natmetabolism.nature.com

Nature Metabolism@natmetabolism.nature.com · last yr.

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

nature.com

Thank you to the organizers of the fantastic meeting #CSMetabolites2025 Kivanc Birsoy @robzonculab.bsky.social and @cellpress.bsky.social editors Allyson Evans @kristabledsoe.bsky.social We had a fantastic time in Sitges, looking forward to this meeting happening again! @cellpressevents.bsky.social

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com A thread 🧵 1/9

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

nature.com

Tomorrow, welcome!

MetaStem@metastem.bsky.social · 2y ago

Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social

Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social

The @katajistolab.bsky.social modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming. Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn Listen to the conversation: bit.ly/4kTt36a

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin

Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

sciencedirect.com

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin

Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

sciencedirect.com

Excited that Pekka is presenting at @CellSymposia Metabolites: Organellar Communication in Health and Disease this May 11–13, 2025, in Sitges, Spain! The abstract submission deadline has been extended until Feb 14th. Hope to see you at #CSMetabolites2025 cell-symposia.com/metabolites-...

Finishing the year with 1st preprint from the lab! Together with @katajistolab.bsky.social and @valerioizzi.bsky.social we investigated the role of basement membrane protein Lama5 and found it is critical for luminal breast cancer initiation and growth www.biorxiv.org/content/10.1...

Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer

Basement membrane (BM) supports and regulates the structural integrity, function and differentiation of epithelial tissues and protects against stromal invasion of breast cancer cells. Here we show th...

biorxiv.org