Happy to share my lab’s latest publication led by Jade Harkin, developing a New Approach Methodology platform to explore the combinatorial effects of inflammatory microglia and astrocytes upon retinal ganglion cells, relevant for glaucoma and other optic neuropathies. www.pnas.org/doi/10.1073/...

A human pluripotent stem cell triculture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation | PNAS

Optic neuropathies, including glaucoma, are characterized by the progressive degeneration of retinal ganglion cells (RGCs), ultimately leading to i...

pnas.org

The Meyer Lab at #ARVO2026!

I'm excited to share our PNAS paper from 1st author Kasia Hussey. We study how the foveola, the high acuity region of the retina, is patterned by RA and TH. We were surprised to find that cone subtypes appear to convert fates. Our studies are important for AMD sufferers. www.pnas.org/doi/10.1073/...

A cell fate specification and transition mechanism for human foveolar cone subtype patterning | PNAS

In the central region of the human retina, the high-acuity foveola is notable for its dense packing of green (M) and red (L) cones and absence of b...

pnas.org

We’re hiring! Join the Sivyer Lab at The University of Sydney as a Postdoctoral Research Fellow in Neurodegeneration within the Snow Vision Accelerator, a $50M initiative tackling glaucoma and optic nerve disease. iPSCs, electrophysiology, drug discovery, and gene therapy.

Happy Halloween from the Meyer Lab! 🎃

Excited to share the latest paper from our lab! Excellent work from Cátia Gomes and Kang-Chieh Huang! Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell–based microfluidic platforms

Shelby Hetzer, a postdoc in the @meyerlab.bsky.social , crushing it at the Stark Neurosciences Institute Summer Science Symposium!

Another exciting pre-print from the lab! This time featuring the work of MSTP student Kaylee Tutrow, we explored the functional consequences of the CX3CR1-V249I polymorphism in human stem cell-derived microglia models! www.biorxiv.org/content/10.1...

Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function

The involvement of microglia in neurodegenerative diseases has drawn increasing attention, as many genetic risk factors are preferentially expressed in microglia. Microglial fractalkine receptor (CX3C...

biorxiv.org

Jason Meyer@meyerlab.bsky.social · last yr.

Happy to share a new pre-print from the lab. Here we use human stem cell models to explore how microglia modulate retinal ganglion cells in developmental and neuroinflammation, both directly and in concert with astrocytes. Amazing work from PhD student Jade Harkin! www.biorxiv.org/content/10.1...

Happy to share a new pre-print from the lab. Here we use human stem cell models to explore how microglia modulate retinal ganglion cells in developmental and neuroinflammation, both directly and in concert with astrocytes. Amazing work from PhD student Jade Harkin! www.biorxiv.org/content/10.1...

A human pluripotent stem cell tri-culture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation

Optic neuropathies, including glaucoma, are characterized by the progressive degeneration of retinal ganglion cells (RGCs), ultimately leading to irreversible vision loss. Increasing evidence implicat...

biorxiv.org

Lab photo (or at least most of the lab) during a tour of the new Medical Education and Research Building at IU School of Medicine. Can’t wait to move in later this year!

waiting on IRG scores to post.....🫣

a cartoon of a woman sitting in front of a computer

ALT: a cartoon of a woman sitting in front of a computer

media.tenor.com

Highly impactful read on the state of Alzheimer's research, and neurodegeneration more broadly. And quite a shout out to Indiana University and the neuroscience programs here at the Stark Neurosciences Research Institute! www.statnews.com/2025/06/17/b...

Bill Gates: I lost my father to Alzheimer’s. But I’m more optimistic than ever about fighting the disease

Bill Gates writes: “We are on the cusp of turning the tide against dementia — which makes this an especially bad time to pull back on research.”

statnews.com

Lab lunch to commemorate Kate’s time with the group as she departs for medical school.

Check out the latest research from the lab of #IUStemCell member Scott Canfield! In this study, they demonstrate that excessive alcohol levels impair the integrity of the blood-brain barrier in human stem cell-derived models, contributing to the onset or worsening of neurological disorders.

Alcohol diminishes barrier integrity in human stem cell-derived brain microvascular endothelial cells: Role of reactive oxygen species

The World Health Organization has linked alcohol consumption to over 200 diseases including neurodegenerative diseases. A dysfunctional blood–brain ba…

sciencedirect.com

In this strange times, attending #ARVO2025 has been a breath of fresh air. Inspired by the work, energized by the community and just so so grateful for the chance to spend time with friends and colleagues ❤

New preprint from the lab! Check it out!

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last yr.

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms https://www.biorxiv.org/content/10.1101/2025.05.02.651934v1

5 posters from the Meyer Lab today! Come check out some exciting work from the lab! First is Shruti Patil presenting work on NF1 model of optic pathway gliomas, A0075

Check out two awesome posters from the lab this afternoon at 2:00 at #ARVO2025! Cátia Gomes will present work on complement activation in astrocytes for glaucoma (A0433) and Aaron Baker will present work exploring stem cell models of APBB2 gene variant in glaucoma (A0434)

Annual gathering of our #AudaciousGoalsInitiative team at @arvoinfo.bsky.social. Lots of exciting work together, and more great ideas to come! #ARVO2025

After meeting get-together with the ARPA-H project crew!

Looking forward to moving into our new, expanded lab space!!!

Bruce Lamb@btlamb.bsky.social · last yr.

Toured the research floors of the brand new Medical Education and Research Building at Indiana University School of Medicine! Some of the best views of downtown Indianapolis on campus! @wilcocklab.bsky.social, @malutansey.bsky.social, @meyerlab.bsky.social, Dr. Jeff Dage, #goteamstark

@meyerlab.bsky.social at the #ARVO2025 Sunday social

Congratulations to Feng Guo and his lab for their recent exciting publication in @cp-cellstemcell.bsky.social where they pursue the use of diffusible scaffolds for functional maturation of midbrain organoids! Very cool work!

Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids

Guo and colleagues developed vascular network-inspired diffusible (VID) scaffolds for engineering midbrain organoids, providing a versatile technology for organoid development and therapeutic innovati...

cell.com

That feeling when you get invited to a zoom meeting from a higher up about a “time sensitive potential opportunity” just to show up and find out that the email was meant for someone else and the wrong Jason was autofilled by Outlook 🤣

two among us characters are standing next to each other and the word imposter is above them

ALT: two among us characters are standing next to each other and the word imposter is above them

media.tenor.com

Wanna grow organoids to understand human retinal development as a research assistant? Wanna help run the lab as a lab manager? The Johnston lab is hiring a research assistant/lab manager. If you are interested, please apply (also please share!): jobs.jhu.edu/job/Baltimor...

Happy to have hosted an informational session from @miltenyibiotec.bsky.social today! Great turnout to hear about some of the latest tools for stem cell research

Two days, and two impressive awards for PhD student Kaylee. Yesterday she was named among IU's "Elite 50" graduate and professional students, while today she received the Pao-Lo Yu award for the top graduating student in the Department of Medical and Molecular Genetics. Proud PI moments!

@iustemcell.bsky.social representing at the Wisconsin Stem Cell Symposium today! #IUStemCell

Proud to be in Detroit presenting our work on NF1 at the Gilbert Family Foundation annual meeting of the Next Generation Models Initiative, led by postdoc Shruti Patil.

2025 Meyer Lab NCAA tournament pool challenge is underway! Let's hope I don't embarrass myself 😉