It’s time for the World Cup final with one of the greatest footballers that may be playing his last cup So time for a short thread on a link between Messi and an intrinsically disordered protein. 1/n

It will be our 10th Next Generation Biophysics Symposium @mrclmb.ac.uk on 16th September. Please join us in person or online and celebrate all things #biophysics www3.mrc-lmb.cam.ac.uk/sites/nextge...

Do you have a bold, daring vision how to transform research in biology? Are you a young scientist within 7 years since your PhD? Submit your idea by July 31 to the Dream Biology Award competition and you can win the first prize of €10,000! More details at dreambiologyaward.org

Our new contribution about #ribosomes. While preparing computer simulations for another project, we noticed that many r-protein parts were missing from the #cryoEM model. Surprisingly, we found this to be a general feature: a coat of #IDPs on the ribosome's surface. www.biorxiv.org/content/10.6...

Ribosomes are covered by a coat of flexible protein fragments

Ribosomal proteins contain flexible terminal regions that are averaged out during electron density reconstructions, rendering them absent from experimental models derived by X-ray crystallography or c...

biorxiv.org

#RNAsky .... Do we have to understand that Ribosomes are flufy sticky blobs rather than granulous dense gobs 🤔🤓

Om Nom Gets Sticky Shocked by Pizza Dough

ALT: Om Nom Gets Sticky Shocked by Pizza Dough

static.klipy.com

Robert Arkowitz@robertarkowitz.bsky.social · 2mo ago

www.biorxiv.org/content/10.6...

🔬 This tenure-track position is roughly comparable to an #assistantprofessor at a US university or to a #newinvestigator position at Max Planck Institutes in Germany. See more ► www.uochb.cz/en/open-posi... ⤵️ #openposition #iocbprague #iocb #compchem

🌽🧬🐛 Together with @natcomms.nature.com and Scientific Reports, we invite articles in all areas of research investigating the roles of RNA in plant biotic interactions (including plant-microbe, plant-insect, and plant-plant interactions). www.nature.com/collections/...

RNA biology in plant biotic interactions

The editors invite articles in all areas of research investigating the roles of RNA in plant biotic interactions.

nature.com

New research shows bacteria can redefine stop codons by shortening tRNA anticodon stems. This "extended superwobble" proves tRNAs aren't passive—they're active drivers that can evolve entirely new genetic codes! doi.org/10.1093/nar/...

We open up to two Junior PI positions at UCT Prague, Czechia @vschtpraha.bsky.social. Broadly defined chemistry-related projects will be considered. A support from any department must be negotiated prior application. Feel free to contact me for further info or visit www.vscht.cz/research/dag....

🧬Linker histone H1 suppresses H4-acetylation–induced H3 N-tail acetylation by altering tail dynamics without affecting the nucleosome core, indicating that H1 restricts euchromatin formation. Find out more in this latest article at www.nature.com/articles/s42...

Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics - Communications Biology

H1 suppresses H4-acetylation–induced H3 N-tail acetylation by altering tail dynamics without affecting the nucleosome core, indicating that H1 restricts euchromatin formation.

doi.org

🧬A new review article discusses the consequences of mutations in genes associated with rare hereditary diseases linked to #G-quadruplex -induced replisome stalling, as well as the molecular functions and cellular pathways of these G4-interacting proteins. doi.org/10.1038/s420...

Rare genetic diseases associated with G-quadruplex-induced replication stress - Communications Biology

The authors review the consequences of mutations in genes linked to rare hereditary disorders associated with G-quadruplex (G4)-induced replisome stalling, as well as the molecular functions and cellu...

doi.org

How can an ordinary clam (well, actually more than 1,600 of these shells) reveal what the fjords on Svalbard looked like thousands of years ago? 🧵👇

Hugo and his poster about the enormous flexibility of the ribosomal tunnel constriction. Preprint available here: www.biorxiv.org/content/10.6...

Huenfeld computational biophysics, 25th anniversary edition. Final slide of the final talk. I feel it the same.

My first author paper is published in @narjournal.bsky.social , co-led with Satish Nandipati and Ambar Kachale. In this work, we build on the implications of the unusual genetic code features of Blastocrithidia nonstop... #RNAsky #RNA #evolution #molecular academic.oup.com/nar/article/...

Our latest contribution is out! In this highly collaborative paper, we show that tRNAs with a 4-base-pair anticodon stem are surprisingly frequent across organisms. Our atomistic MD simulations reveal the role of the 5th base pair. academic.oup.com/nar/article/...

Frequent occurrence and predicted functions of tRNAs with 4-base-pair anticodon stems in bacteria: extended superwobble hypothesis

Abstract. Recently, a tRNATrpCCA with a 4-base-pair (bp) anticodon stem (AS) was shown to efficiently recognize a near-cognate UGA codon in unicellular euk

academic.oup.com

Thermus thermophilus forms two distinct type IV pili. Cryo-electron microscopy, mutagenesis, structural predictions and simulations reveal their structures, glycan flexibility, and a hypothetical model of pilus assembly. www.nature.com/articles/s42...

Analysis and Sampling of Molecular Simulations with Adversarial Autoencoders by @guted.bsky.social doi.org/10.1063/5.03...

Analysis and sampling of molecular simulations with adversarial autoencoders

The design of good collective variables for analysis and the enhancement of sampling of molecular simulations is not a trivial task. It often relies on the know

doi.org

There is an unplanned power outage in Prague 6. It appears that the servers of the Czech Science Foundation GACR (including #GRIS) are affected and therefore currently unreachable.

Our recent investigation of the constriction in the bacterial ribosomal tunnel is online. Unbiased all-atom MD simulations of the entire ribosome and PDB analysis show, how flexible the constriction is. The flexibility is modulated by short nascent polypetides.

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 5mo ago

Early nascent polypeptide dynamics are coupled to the flexibility of the ribosomal tunnel constriction https://www.biorxiv.org/content/10.64898/2026.03.10.710814v1

🧬Submissions are still open for our DNA repair and human disease Collection, a cross-journal Collection, highlighting new research and methodological advances. www.nature.com/collections/... ⚠️ Submission Deadline: 31 January 2026

DNA repair and human disease

This cross-journal Collection between Nature Communications, Communications Biology and Scientific Reports welcomes submissions on the mechanisms of DNA ...

nature.com

💡Since November 2025, @springernature.com has introduced "Articles in Press", an initiative giving authors earlier visibility without compromising the quality or integrity of the final publication. ⌛Faster access to accepted research! For more information: support.springernature.com/en/support/s...

Some thoughts on the chronic underfunding of the Czech Science Foundation. Much of this problem stems from the recent Ministry of Education’s sloppy implementation of funding for non-teaching staff at grammar schools. gacr.cz/informace-o-...

Some facts about the Standard GACR grants awarded this year (in parentheses last year values): - grants funded: 336 (410) - budget: 3.0B CZK (3.4B) - women PI proportion: 25.6% (21.2%) - proportion of grants in social and humanities: 25.6% (27.3%)

New publication about peptide transport through confined space with some implications for MD simulations of nascent polypeptides in the ribosomal exit tunnel. pubs.rsc.org/en/content/a...

Sensitivity of peptide conformational dynamics in carbon nanotubes to directional mechanical forces

In living organisms, proteins and peptides are often under the influence of mechanical forces, especially in confined spaces such as membrane channels, the ribosome exit tunnel, or the proteasome gate...

pubs.rsc.org

The 14% success rate the main Czech funding scheme for fundamental research is simply a disaster. gacr.cz/en/next-year...

Excited to share a fantastic set of sessions coming up at the MDDB Conference: Day 1: Large-scale MD simulations Day 2: MD kinetics and free energy / Industrial applications of MD Day 3: Innovative applications of MD to biological systems Explore more and register at ➡️ mddbr.eu/conference/ #MDDB

Happy to take part in the workshop. Lots of inspiring discussions. The take-home message: there are many interesting research problems, but only some are truly important.

Human Frontier Science Program@hfspo.bsky.social · 8mo ago

Greetings from Prague! The HFSP Masterclass is in full swing 🇨🇿 — welcoming early career researchers from Central Europe to explore HFSP funding, frontier science, and international collaboration. #HFSPmasterclass #HFSP #GlobalScience #ScienceWithoutBorders 🧪 #sts

Day 1 of the winter semester. Good luck to all of us @vschtpraha.bsky.social.

At EMBL @events.embl.org , they know how to conclude a conference. #EMBLProtein