Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics

Nature Communications - Alternative splicing generates diverse protein isoforms, yet the functions of most exons remain unknown. Here, the authors introduce scCHyMErA-Seq, a scalable single-cell...

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The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations - Nature Communications

Here the authors measure how the absence of certain DNA repair genes change the frequencies of unique mutational outcomes generated by Cas9 DSBs at synthetic target sequences in mouse embryonic stem c...

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