1st genome sequenced (Sanger 1977), 1st genome synthesised (Venter 2003), 1st genome + proteome fully mutated (Huijin Xiangua 2026!) @crg.eu @sangerinstitute.bsky.social Complete Mutagenesis of the Genome and Proteome of ΦX174 www.biorxiv.org/content/10.6...

Complete Mutagenesis of the Genome and Proteome of ΦX174

The bacteriophage ΦX174 was the first genome to be sequenced and the first to be chemically synthesised. Here we present a complete map of the consequences of changing every nucleotide in the ΦX174 ge...

biorxiv.org

New @talusbio.bsky.social #AI preprint just dropped 🚀 Meet Ptarmigan-1. It predicts which small molecules bind a protein, and which residues they hit, from sequence and 2D chemistry alone. No structures, no docking, no poses. www.biorxiv.org/content/10.6... Time for a 🧵 (1/13)

Structure-free, site-resolved contrastive learning extends small-molecule discovery beyond the reach of structure-based modeling

Virtual screening asks which molecules, among an enormous space of drug-like chemistry, are worth synthesizing and testing against a protein target. Most modern methods answer by building and scoring ...

biorxiv.org

Do you want to work at the frontier of structural and chemical #proteomics? Interested in induced proximity and building a feedback loop for machine learning models to explore biology? I'm hiring! Apply below ⬇️ jobs.ashbyhq.com/proxima/6e39...

Proteomics Scientist

Proteomics Scientist

jobs.ashbyhq.com

If you're in town for #ASMS2026 and want to talk chemoproteomics, computational proteomics, or generating high-throughput data for training ML models - hit me up!

Looking for a burrito at #ASMS2026? Definitely hit up The Taco Stand: maps.app.goo.gl/fSYTwvyUCs57...

As an example: using codex, I compiled Sage to WASM and you can run real-time search directly (and change parameters) in your browser without installing anything: lazear.github.io/sage-wasm-de...

Ben Neely@benneely.com · 3mo ago

Yep. Everything will be built on Sage. Not joking.

🧪 Transforming biomedical discovery needs proteomics that is specific and accurate, but also faster and cheaper @parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇 www.biorxiv.org/content/10.1...

@michaellazear.bsky.social & @jspaezp.bsky.social I'm Running Sage on a dual Epyc 128 thread box w/ 2TB memory (I think) . Searching 19 ddaPASF files directly with built in timsRUST!! Dang this is screaming fast !!

Chiang and Collins making a fun Casanovo + Sage (w/Mokapot et al.) metaproteomics pipeline (Bittremieux, @michaellazear.bsky.social @willfondrie.com) … and an exceptional TOC graphic.

PastelBio@pastelbio.bsky.social · 2y ago

Orthrus: an AI-powered, cloud-ready, and open-source hybrid approach for metaproteomics www.biorxiv.org/cont... --- #proteomics #prot-preprint

Trying to do some research for buying a new road bike and I have stumbled upon something truly cursed... what appears to a forum of just LLMs talking to one another: www.cyclingforums.com/threads/gian...

This is Big for #quantms team. Let me explain some of the big improvements: - Sage integration thanks to @michaellazear.bsky.social - Bruker and library based DIA support thanks to @jspaezp.bsky.social - Major improvements in LFQ pipeline and pmultiqc reports. - Lot of bugs fixed from version 1.1.1.

nf-core@nf-co.re · 3y ago

Pipeline release! nf-core/quantms v1.2.0 - nfcore/quantms v1.2.0 - Thimphu! Please see the changelog: https://github.com/nf-core/quantms/releases/tag/1.2.0

I’ve never seen someone with such polished twitter threads, which have now been rolled into a JPR paper. I think @michaellazear.bsky.social is on to something great with SAGE, especially its openness. Looking forward to seeing this engine powering proteomics. (h/t @pastelbio.bsky.social)