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Mike Krashes

@mikekrashes.bsky.social

Your arms too short to box with god

11 Posts629 Follower349 Folgt
Kate Wassum@katewassum.bsky.social · last yr.

🚨📃New Wassum Lab Paper📃🚨 Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇 www.nature.com/articles/s41... Free full text: rdcu.be/eaxEv

A dual-pathway architecture for stress to disrupt agency and promote habit - Nature

Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

nature.com

Henning Fenselau@henningfenselau.bsky.social · last yr.

www.science.org/doi/10.1126/... very excited to share our latest work, out now in Science. Congratulations to Marielle who led our studies! And, all other authors - this was a wonderful collaborative effort

Thalamic opioids from POMC satiety neurons switch on sugar appetite

High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...

science.org

Annegret Falkner@neurrriot.bsky.social · 2y ago

New year new work from the lab! We explore whether aggression experience and observation lead to similar changes in future aggression strategy. (They do!) We perform 2-color imaging across the whole social behavior network across time and track changes www.biorxiv.org/content/10.1...

Aggression experience and observation promote shared behavioral and neural changes

The ability to observe the social behavior of others and use observed information to bias future action is a fundamental building block of social cognition. A foundational question is whether social o...

biorxiv.org

Jan Siemens@jansiemens.bsky.social · 2y ago

My inaugural post on Bluesky - quite fittingly, I'm thrilled to share our first study on heat acclimation, which identifies a neuronal mechanism that drives heat tolerance in mice. (www.nature.com/articles/s41... ) Here is the gist 🧵 (1/n):

Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance - Nature Neuroscience

Ambroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives...

nature.com

Randy J Seeley@seeleyrj.bsky.social · 2y ago

Latest from our group in collaboration with Lotte Bjerre Knudsen and other Novo scientists. They developed a GLP-1/Leptin co-agonist that we put through its paces in a number of mouse models to prove that both parts of the molecule matter. More options on the table! www.science.org/doi/10.1126/...

Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist

Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.

science.org

Current Biology@currentbiology.bsky.social · 2y ago

Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue www.cell.com/current-biol...

Glucagon-like peptide-1 receptor

Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role in glucose metabolism and the mode of action of their agonists that are used to treat obesity and were later shown...

cell.com

Mike Krashes@mikekrashes.bsky.social · 2y ago

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5

Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety

Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.

rdcu.be

Linda Rinaman@neurorinaman.bsky.social · 2y ago

Stress, GLP1, hypothalamus, NTS, what more could you want? Collaboration across the pond led by the amazing Dr. Marie Holt @MKBHolt www.sciencedirect.com/science/arti...

Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract

Stress-induced behaviours are driven by complex neural circuits and some neuronal populations concurrently modulate diverse behavioural and physiologi…

sciencedirect.com