Milo B. Fasken, Ph.D.
@milofasken.bsky.social
Senior Scientist, Department of Biology, Emory University, Atlanta, GA. Molecular Biologist. RNA Scientist. Yeast Geneticist 🧬. British🇬🇧. Runner 🏃🏻…. Opinions are my own. Interests: RNA Decay, RNA Processing, RNA & Disease.
The abstract submission deadline for #EESRNA is only a week away! Don't miss your chance to present your research at the EMBO | EMBL Symposium 'The complex life of RNA', the central event for the RNA community. Submit your abstract by 7 July: s.embl.org/ees26-12-bl #RNA #RNAbiology
Nice work! #RNAExosome #RNA link.springer.com/article/10.1...
Cellular assembly and functional resilience of the mammalian RNA exosome - The EMBO Journal
Most eukaryotic proteins assemble into multisubunit complexes that coordinate essential cellular functions, yet the principles governing their assembly and proteostatic control remain largely undefine...
link.springer.com
Great 1st Day at #RNADecay26 Cheers to organizers: Elena Conti Hannah Mischo Allen Buskirk Gene-Wei Li Great talks from Lori Passmore, Aaron Goldstrohm, Anita Corbett, Sutapa Chakrabarti, Ambro van Hoof, and Chris Lima, amongst others. 😊
Congrats, David Tollervey! 2025 RNA Society Lifetime Achievement in Science Award Winner: Dr. David Tollervey Wonderful talk on rRNA processing, the RNA exosome, stress, budding yeast, and…..the “Unknome” #RNA26
Great talk and song on m6A and Candida albicans by Allison M. Porman Swain! 👏😊 #RNA26
#RNAExosome www.cell.com/trends/cell-...
Precision in RNA degradation: helicases, ribosome and RNA polymerase stalling, and RNA modifications
Errors in transcription and RNA processing generate aberrant transcripts that can produce truncated, nonfunctional, or dominant-negative proteins. RNA surveillance pathways, centered on the RNA exosom...
cell.com
Excited to highlight the new Special Issue of RNA showcasing advances in system-level RNA biology, from epitranscriptomics and RNA damage to deep learning–driven structure prediction and beyond #RNAbiology #Epitranscriptomics #RNAseq #ComputationalBiology #Genomics bit.ly/4tEQL9I
rnajournal.cshlp.org/content/earl...
Genetic and genomic approaches to explore roles for the conserved 3’-5’ exoribonuclease EXOSC10 in normal and malignant cells
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
rnajournal.cshlp.org
www.nature.com/articles/s41...
Composite SMG5-SMG6 PIN domain formation is essential for NMD - Nature Communications
Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that ...
nature.com
Edoardo Gianni@edogia.bsky.social · 6mo agoHow could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n
Dmitry Kretov@dmitry-kretov.bsky.social · 6mo agoHappy to share the first review article from our lab! We discuss the landscape of available high-throughput approaches for profiling RNA–protein interactions in vitro and in vivo. We hope it will be useful when designing your next experiment. www.tandfonline.com/doi/full/10.... #RNAsky
What’s #UPF1 www.nature.com/articles/s41...
Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay - Nature Communications
Replication-dependent histone mRNA decay involves the RNA helicase UPF1, the histone stem-loop binding protein SLBP and the exoribonuclease 3’hExo. Here, the authors present evidence for assembly of a...
nature.com
Happy New Year! Wishing everybody some “Good Science” for 2026! 🧬😊
Exollent! Congrats! #RNAExosome #RNA www.cell.com/cell-reports...
The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain
Higginson et al. present a cell-type-resolved atlas of RNA exosome dysfunction in the Drosophila brain, showing that pathogenic Rrp40 mutations disrupt RNA surveillance and neuronal integrity. This re...
cell.com
My "News & views" was published today @natmethods.nature.com Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left... www.nature.com/articles/s41...
Targeted RNA-binding protein degradation to improve mRNA live imaging in animal cells - Nature Methods
The gold standard system for mRNA imaging in live cells just got upgraded by being degraded. This development improves signal-to-noise ratios and may lead to a better understanding of mRNA transport a...
nature.com
My talk from the latest RNA Collaborative Seminar Series is now available on YouTube. The second talk in the session was given by Rachel Braun (Sara Cherry’s lab) on TTP and its role in regulating antiviral immunity. youtu.be/2Aj-xbi3dPI #RNAsky #RNAbiology
December 10: NCI RNA Biology Initiative & Penn Institute for RNA Innovation
YouTube video by RNA Collaborative Seminar Series
youtu.be
#NEXT story to read! Cheers! #RNAExosome www.cell.com/cell-reports...
Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops
R loops form during transcription, threatening the genomic stability of hematopoietic stem cells (HSCs) and lymphoma cells. Pan et al. report that ZCCHC8 safeguards the genome integrity and self-renew...
cell.com