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Eugene Valkov

@eugenevalkov.bsky.social

mRNA regulation & decay | biochemistry | structural biology | molecular biology | cancer All views are personal. Google Scholar: tinyurl.com/EuValScholar ORCID: 0000-0002-3721-1739

750 Posts3058 Follower2761 Folgt
Matthew Cobb@matthewcobb.bsky.social · last wk.

It's my thesis that the Habsburg/Hapsburg lip/jaw was noticed as a family trait only in the mid-C19 (so sez ngram viewer), but I can't find any decent historiography of the issue, despite it being so notorious. There's loads of medical speculation, but that's not what I'm after. Any ideas? Pls RT

Quaid Morris@quaidmorris.bsky.social · 2w ago

Can we predict which T cells recognize which peptides? A lot of the signal is hiding in AlphaFold3's (AF3's) hallucinations. enFoldX: instead of one predicted structure, we use the whole noisy ensemble to predict TCR:pMHC binding. www.biorxiv.org/content/10.6... 💻 🧬 github.com/jonlevi/enFoldX

Ensembles of in silico structures enable T cell peptide-MHC binding prediction

Adaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC). Accurate prediction of TCR:pMHC binding pairs from sequence data rem...

biorxiv.org

Sebastian S. Cocioba@atinygreencell.bsky.social · 4w ago

@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...

OpenEvo: An Open-Source Platform for Automated Evolution and Analysis

Here we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-s...

biorxiv.org

Shicheng Guo@shihcheng.bsky.social · last mo.

Ribonuclease DIS3 extends aging by generating crucial tRNA halves in C. elegans. 5'-tRH-Gln is vital for longevity via various interventions like dietary restriction. PMID:42168172, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73295-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Ribonuclease DIS3 delays aging and senescence by generating tRNA halves | Nature Communications

Transfer RNA (tRNA) halves (tRHs) are generated via the cleavage of tRNAs, but their roles in aging and longevity remain poorly understood. Here, we demonstrate a direct role of tRHs in aging in metazoans. Through a genetic screen using Caenorhabditis elegans, we identify DIS-3/DIS3 as a ribonuclease that catalyzes tRH generation, including 5′-tRH-Gln and 5′-tRH-Asp, from tRNAs. Among them, 5′-tRH-Gln is essential for longevity conferred by various interventions, including dietary restriction. Generation of 5′-tRH-Gln reduces translation via ribosomal protein binding and upregulates the SKN-1/NRF transcription factor responsible for lifespan extension. We further show that mammalian DIS3 contributes to tRH generation and delays cellular senescence through translation downregulation by another tRH, 5′-tRH-Cys. Overall, our data demonstrate that DIS-3/DIS3 is an evolutionarily conserved tRH-generating ribonuclease that counteracts organismal and cellular aging. Direct roles of tRNA halve

doi.org

David Bartel's Lab@bartellab.bsky.social · 2mo ago

Two new preprints featuring work from @ryanymuller.bsky.social on PABPC biology! With important contributions from @eugenevalkov.bsky.social, Tanner Myers, and @kxwang.bsky.social

The molecular determinants of PABPC-mediated deadenylation rate

Deadenylation, the enzymatic shortening of the poly(A) tail, is typically the first committed step of mRNA decay. Deadenylation rates span nearly a 1000-fold range between transcripts and are governed...

biorxiv.org