#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

Widespread immune systems protect bacteria against conjugative plasmids

Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...

biorxiv.org

📖 Check out this review published in the special NMD issue of the Journal of Molecular Biology by @frafiorini.bsky.social (MMSB) and Vincent Mocquet (LBMC) @lbmcinlyon.bsky.social. ☀️ Great summer reading if you're interested in helicases and molecular machines! www.sciencedirect.com/science/arti...

UPF1 at Work: Structural and Mechanistic Insights Into a Master Regulator of Nonsense-Mediated mRNA Decay

RNA helicases are central architects of ribonucleoprotein (RNP) organization, coupling nucleoside triphosphate hydrolysis to RNA binding to unwind dup…

sciencedirect.com

📖 New publication from the B3P team (Christophe Grangeasse) on the selection of the division site in Streptococcus pneumoniae by MapZ. 🎉Congratulations to Adrien Ducret (now @ciri-lyon.bsky.social ), Céline Freton, Cassandra FALCOU and Sathya Narayanan NAGARAJAN! pubmed.ncbi.nlm.nih.gov/41946898/

Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae - PubMed

Accurate division site placement is essential for bacteria to produce viable daughter cells. In the ovoid-shaped Streptococcus pneumoniae, previous work showed that division site placement depends on ...

pubmed.ncbi.nlm.nih.gov

📖 New publication from the B3P team on bacterial adaptation to antibiotic stress through post-translational modifications of a cell division protein ✨ Congrats to the authors (MMSB: Sylvie Manuse, Jean-Pierre, Léo Claude and Christophe Grangeasse)! doi.org/10.1093/pnas...

🎓 Researchers from @mmsb-lyon.bsky.social will participate to "Microbes in Focus" Erasmus+ BIP 🧬 A great opportunity to explore modern tools for engineering microorganisms while strengthening European collaborations 👉 sites.google.com/view/microbe... coordinator: @macerwan.bsky.social (Univ. Lyon I)

Microbes in Focus

Erasmus+ Blended Intensive Programme — Lyon, FranceMicrobes in Focus: Modern Tools for Understanding and Engineering Microorganisms

sites.google.com

🎤Stephanie Ravaud, from the Bacterial Pathogens & Protein Phosphorylation Team at MMSB, presenting her work on "How bacterial cell Wall chemistry shapes animal growth: insights across biological scales in a symbiotic system" today at the SFR Biosciences Scientific Day Models across scales in Biology

It was a great pleasure to host @aharms485.bsky.social at @ciri-lyon.bsky.social and @mmsb-lyon.bsky.social ! Great science and insightful discussions on the dark side of viral genomes 😎

📢 Opportunity to apply for a PhD fellowship to join our group and work on MGE-MGE interactions and phage defence systems! @mmsb-lyon.bsky.social See informations about eligibility and research project on this web page: graduate-plus.fr/immunology-v... Contact me if you are interested !

🎥 As part of the "Échappées Inattendues" (by @cnrs.fr), check out the replay of the immersive conference "The Secrets of Rebel Bacteria", presented on Oct 11, 2025 at the Vaux-en-Velin Planetarium by J.M. Jault (ABC transporters and resistance to antibiotics team) www.youtube.com/watch?v=kSWJ...

Les secrets des bactéries rebelles | Conférence immersive | Les Échappées inattendues

YouTube video by CNRS

youtube.com

🎉Extremely happy that Josie Elliott was awarded a MCSA postdoctoral fellowship to continue our work on the competition between mobile genetic elements in bacteria ! Congratulations !

Josie Elliott@josie-e.bsky.social · 6mo ago

I'm excited and grateful to share that I have been awarded a Marie Skłodowska-Curie postdoc fellowship for my work with @annechevallereau.bsky.social at @mmsb-lyon.bsky.social. I feel incredibly lucky and I'm looking forward to getting to work on all the phage-y experiments we have planned 🧫

Congratulations to @josie-e.bsky.social for being awarded a MSCA postdoc fellowship! 👏

Josie Elliott@josie-e.bsky.social · 6mo ago

I'm excited and grateful to share that I have been awarded a Marie Skłodowska-Curie postdoc fellowship for my work with @annechevallereau.bsky.social at @mmsb-lyon.bsky.social. I feel incredibly lucky and I'm looking forward to getting to work on all the phage-y experiments we have planned 🧫

📢 Recrutement d’un(e) Maître(sses) de conférence en Biochimie générale, spécialité bactériologie moléculaire à MMSB 🔬Recherche *Immunité anti-phages *Réponse au stress, modulation de la croissance bactérienne ✉️ christophe.grangeasse@cnrs.fr 📚Enseignement : Université Lyon I ✉️ patrice.gouet@ibcp.fr

📖 Review from the Terradot lab at MMSB on Brucella's Type IV secretion system and effector proteins Congratulations! @laurentterradot.bsky.social

FEMS Journals@femsjournals.bsky.social · 6mo ago

🦠 @laurentterradot.bsky.social lab reviews #Brucella’s #T4SS—a key virulence factor—covering its structure, function, and growing effector arsenal. It also explores how effectors enter host cells, opening new paths to understand and target infection. 🔬 👉 buff.ly/KW4kVN4

New publication from the Lesterlin (TacC) team at MMSB! Congratulations to all authors. In collaboration with Pierre Bogaerts (UCL Belgium) and J. Villa (UB Barcelona) doi.org/10.1093/nar/...

New publication from the Grangeasse's team at MMSB! Congratulations to all authors. In collaboration with Cecile Morlot (IBS, Grenoble) and David Rooper (Warwick university). To know more : rdcu.be/eVsin

Streptococcus pneumoniae S protein activates PBP1a to regulate peptidoglycan remodelling and cell division

Nature Microbiology - S protein interacts with and activates PBP1a during cell division, as part of a larger GpsB-associated multiprotein complex that coordinates peptidoglycan remodelling in...

rdcu.be

📖 New publication from the Jault and Orelle’s team at MMSB! Congratulations to all authors. In collaboration with @hellmichgroup.bsky.social and Julien Marcoux. www.nature.com/articles/s41...

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter - Nature Communications

The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric pathway critical for function...

nature.com

Two conferences two weeks apart, thank you to everyone who came and chatted to me at my poster (or in general) at the Phages.fr conference in Nancy and the @microbiologysociety.org #MicroEvo25 conference in Liverpool. It was great to show the first data from my postdoc and get advice and feedback

JOB OFFER #PhageSky We have a postdoc position opening in my group to investigate phage-MGE interactions ! We're based in the very nice city of Lyon, France @mmsb-lyon.bsky.social Contact me for more info ! >> Apply on the CNRS webpage emploi.cnrs.fr/Offres/CDD/U...

#Radio 📻| Jean-Michel Jault du @mmsb-lyon.bsky.social était au micro de @rcflyon.bsky.social pour parler de la lutte contre l'antibiorésistance des bactéries🦠 👉 www.rcf.fr/economie-et-... Envie d'en savoir plus❓ RDV samedi au planétarium de @vaulx-en-velin.bsky.social pour sa conférence immersive

Comment lutter contre l'antibiorésistance des bactéries ? | Dis, pourquoi ? · RCF Lyon

Le slogan « Les antibiotiques, c’est pas automatique » a marqué des générations de Français. Mais savons-nous expliquer pourquoi ? En écho aux actions proposées par le CNRS dans le cadre de la Fête de...

rcf.fr

Congratulations to Jackson Crowley for winning the 2025 MMSB Prize for Best PhD Student Oral Communication! We were all fascinated to see how lipids can bud from the phospholipid membrane to form lipid droplets. Well done!

#Évènement🎟️| Lancement de la 3️⃣ème saison des #ÉchappéesInattendues du @cnrs.fr avec la conférence immersive de Jean-Michel Jault, biologiste au @mmsb-lyon.bsky.social sur l’antibiorésistance 🧫 des bactéries 🦠 pour la #FDS2025 📅 11 octobre 🕢 à 17h30 ✔️ sur inscription : bit.ly/confmmsb #FDSAURA

Ces travaux impliquent le laboratoire Microbiologie moléculaire et biochimie structurale @mmsb-lyon.bsky.social.

CNRS Biologie@cnrsbiologie.bsky.social · 11mo ago

#ResultatScientifique🔎| Des scientifiques ont révélé comment le plasmide pOXA-48 rend les bactéries ultra-résistantes aux antibiotiques 🦠 🤝 @cnrs.fr @mmsb-lyon.bsky.social @cnrs-rhoneauvergne.bsky.social ✍️ @sbigot.bsky.social 📕 @natcomms.nature.com | buff.ly/u3Cy4Db

📝New preprint! We investigated how spatial structure affects cooperation between phages, combining mathematical modelling and experiments. A short thread 🧶

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 12mo ago

The ambivalent effect of spatial structure on the spread of cooperative anti-CRISPR phages https://www.biorxiv.org/content/10.1101/2025.08.06.668856v1

Check out the first preprint from our lab describing a direct molecular cross-talk between (p)ppGpp and c-di-GMP nucleotide messengers! Great work from first-author Corentin Jaboulay who was a postdoc in our lab, and great collaborations! @mmsb-lyon.bsky.social @cnrsbiologie.bsky.social

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 12mo ago

Cross-regulation of (p)ppGpp and c-di-GMP pathways controls a cell-cycle transition https://www.biorxiv.org/content/10.1101/2025.08.22.671821v1

Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨ 👉 www.nature.com/articles/s41... @cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social

Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli - Nature Communications

pOXA-48 plasmids have emerged as key vectors of carbapenem resistance within Enterobacteriaceae. In this study, the authors use a transposon sequencing (Tn-seq) approach to identify genetic determinan...

nature.com

🌿Congrats to the Equipe Projet VERT: Marine Blanc, Sandrine Magnard, Lauriane Lecoq (MMSB UMR 5086), Sandrine Vadon-Le Goff (LBTI UMR 5305), Nicolas Grimault (IBCP UAR 3760) and Virginie Gueguen-Chaignon (SFR Biosciences UAR 3444) for their Cristal Collectif Medal! ✨Towards more sustainable science!

CNRS@cnrs.fr · last yr.

👏 Félicitations aux lauréates et lauréats 2025 de la Médaille de cristal collectif qui distingue des équipes d’appui à la recherche, ayant mené des projets particulièrement remarquables. 👉 www.cnrs.fr/fr/actualite... #TalentsCNRS

La saison 3️⃣ des conférences immersives revient à la rentrée pour la #FDS25 ‼️ 📅 samedi 11 octobre 🕢à 17h30 🗣️avec Jean-Michel Jault du @mmsb-lyon.bsky.social qui dévoilera les secrets des bactéries rebelles Pensez à vous inscrire dès maintenant 👇 🎟️https://bit.ly/confimmersivemmsb

Résistance aux antibiotiques, pour en savoir plus sur le paradoxe des biofilms ⤵️ 🤝 @sbigot.bsky.social @knutdrescher.bsky.social @cnrs-rhoneauvergne.bsky.social‬ @mmsb-lyon.bsky.social‬ 👉 Lire l'article dans ‪@pnas.org‬ buff.ly/IWjV6LV buff.ly/Ok2lZU6

Dans l’intimité moléculaire du virus de l’hépatite D ? De nouvelles stratégies thérapeutiques ciblant l’assemblage du virus 🦠 🤝 ‪‪ @cnrs-rhoneauvergne.bsky.social‬ 👉 L'article dans @pubs.acs.org‬ buff.ly/qR4S6l1 👉 L'article dans @pnas.org‬ buff.ly/DpzH5eQ buff.ly/gISBHZa

Congratulations to Lauriane @mmsb-lyon.bsky.social and all the group for this splendid work

CNRS Biologie@cnrsbiologie.bsky.social · last yr.

Dans l’intimité moléculaire du virus de l’hépatite D ? De nouvelles stratégies thérapeutiques ciblant l’assemblage du virus 🦠 🤝 ‪‪ @cnrs-rhoneauvergne.bsky.social‬ 👉 L'article dans @pubs.acs.org‬ buff.ly/qR4S6l1 👉 L'article dans @pnas.org‬ buff.ly/DpzH5eQ buff.ly/gISBHZa