The power of sugars. #ERCAdG I am particularly happy to announce that Ive been assigned an ERC AdG (PE5) to crack the LPS code. thanks to my group!!! @erc.europa.eu
Tony Molinaro
@molinarotony.bsky.social
Full professor of Organic Chemistry @Unina and @OsakaUni. Sugars/NMR. Addicted fan of D10S and Led Zeppelin. Opinions are definitely mine and often wrong.
👇 #Siglec-7 NMR assignment and binding studies with #gangliosides, impact of ligand flexibility #nmr #3D #glycan #glycotime #GD3 #structuralbiology #biophysics @robertamarchetti.bsky.social @molinarotony.bsky.social advanced.onlinelibrary.wiley.com/doi/10.1002/...
Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility
The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec-7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A comb....
advanced.onlinelibrary.wiley.com
👇🏾Free #NMR School "The new frontiers of NMR: Advanced Applications", May 26th to 29th (Dept. of Chemical Sciences, University of Napoli Federico II) open to PhD students and Postdoc. To apply please email your CV to simone.potenti@unina.it by April 21st
✨✨ It's #glycotime for #HIV Env ✨✨ N-linked glycans modulate flexibility & MPER epitope exposure #glycotime Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪 Would love feedback! www.biorxiv.org/content/10.1...
Thanks #ACSCarb division for awarding me with the ACS 2025 Melville L Wolfrom award acscarb.org/awards/wolfrom… Truly honoured to have received this recognition and celebrate with friends and colleagues
Registration is open for the 2025 Gordon Research Conference on Carbohydrates and the associated Gordon Research Seminar! 🧪 We have a exciting line-up of confirmed speakers and more to be added! www.grc.org/carbohydrate... The conference will be held June 15 - 20 in Holderness, NH.
Young PhDs beyond their poster communication GRC Barga Glycofriends
Thanks to Ratmir Derdra, our #glycotime answer to "The risk of mirror life" appears now under the article in Science www.science.org/doi/10.1126/... With @glycoexpasy.bsky.social @laurakiessling.bsky.social @carolynbertozzi.bskyverified.social @molinarotony.bsky.social @dbojar.bsky.social and many
Confronting risks of mirror life
Broad discussion is needed to chart a path forward
science.org
Napoli, springtime. Organic chemistry II. Starting lesson.
Picture this: your fav protein-protein interaction is *entirely* dependent on, 1) glycans 💥 2) the type of glycans 🤯💜 Check out this doi.org/10.1016/j.jb... 🔝 #glycotime fresh off the press in JBC led by Nicki Packer and Len Harrison 🇦🇺 + us 🇮🇪🇬🇧 + @ethangbaus.bsky.social 🇦🇺 🧵1/5
Thanks to Ratmir Derda we have an articulate reply to: www.science.org/doi/10.1126/... putting glycans back into the picture! @laurakiessling.bsky.social @anneimb.bsky.social @carolynbertozzi.bskyverified.social @molinarotony.bsky.social @dbojar.bsky.social @siglecdude.bsky.social
Confronting risks of mirror life
Broad discussion is needed to chart a path forward
science.org
Excited to be back in Naples to deliver a CINMPIS lecture on photoresponsive G4 ligands @BristolChem - such a wonderful meeting on synthesis methodology and innovation … and such a beautiful place.
We're back!!! First preprint of the year (3 more on the way). Here, we used microalgae to produce a 3D printable resin: Squeeze the oil from the microalgae, a couple of simple reactions (#chemsky), mixy mixy and there you have a strong bioresin. chemrxiv.org/engage/chemr...
Discovery of a new Cu-dependent cellulose degrading enzyme for biomass conversion #glycotime (trying to overlook the extraneous proton, see if you can find it) www.nature.com/articles/s41...
A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion - Nature
A metalloenzyme capable of oxidatively cleaving cellulose, found in a microbial community specialized in lignocellulose degradation, could enable sustainable biofuel production.
nature.com
Absolutely love this new ChemBioChem cover by the Akira Wada lab. Also, it is the journal's 25th anniversary this year in case you noticed the little logo on the cover (more to come soon!). chemistry-europe.onlinelibrary.wiley.com/toc/14397633... @chemistryeurope.bsky.social
Neapolitan group meeting ending up with some wine. Season greetings to all of you out in the Bluesky ❤️❤️❤️
Christmas arrived early for me🎄🎁 just got a hard copy of the Nature Methods Nov 2024 issue with our GlycoShape article in it ❤️❤️ it smells sooo nice!!! 🤩🤣 doi.org/10.1038/s415...
This was an amazing collaboration with high affinity ligand for Pseudomonas aeruginosa lectins able to target the bacteria in mice !! #glycotime 🍾
Alexander Titz@titzlab.bsky.social · 2y agoI am very proud to share a long story on lectins and biofilm imaging just published in JACS Au by Eva and Lisa in cooperation with many colleagues such as @anneimb.bsky.social 😍 #glycotime #chembio #AMR please have a look here: pubs.acs.org/doi/10.1021/...
Structure of the K58 capsular polysaccharide produced by Acinetobacter baumannii isolate MRSN 31468 includes Pse5Ac7Ac that is 4-O-acetylated by a phage-encoded acetyltransferase #glycotime #CarbohydrateResearch
Structure of the K58 capsular polysaccharide produced by Acinetobacter baumannii isolate MRSN 31468 includes Pse5Ac7Ac that is 4-O-acetylated by a phage-encoded acetyltransferase
Capsular polysaccharide (CPS), a heteropolymeric carbohydrate structure present on the cell surface of most isolates of the bacterial pathogen Acineto…
sciencedirect.com
"About 250 publications contain errors in the 13C NMR assignment of glycans" Remediation of the NMR data of natural glycans, Kirill Kazantsev, Philip Toukach www.sciencedirect.com/science/arti... #NMRchat #NMR 🧲
Remediation of the NMR data of natural glycans
Primary structure elucidation in glycobiology is strongly affected by published structure-reporting NMR signals, especially on the 13C nucleus. The gl…
sciencedirect.com
…cause nothing last forever, even cold November rain. (Cit. W. Axl Rose)
