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Microbial Pathogenicity Mechanisms

@mpm-hki.bsky.social

Research group @leibniz-hki.de in Jena, Germany. Studying pathogenicity of yeast-y beasties in the 𝘊𝘢𝘯𝘥𝘪𝘥𝘢 clade. 🧫🔬🦠🍄 Head: Prof Bernhard Hube Webpage: https://www.leibniz-hki.de/en/microbial-pathogenicity-mechanisms.html

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Microbial Pathogenicity Mechanisms@mpm-hki.bsky.social · 3mo ago

PhD Defence Announcement Come join us as Osama Elshafee, PhD student in the MPM Department at HKI, defends his thesis on the topic: “The dual roles of the Candida albicans lipase gene family in host colonization and infection” 📍Seminar room Louis Pasteur, Leibniz-HKI 🕒 15:15 🗓 May 7, 2026

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ASM@asm.org · 5mo ago

Should I stay or should I go? Research in #mBio suggests the fungus Candida glabrata may actively prolong the part of its life spent inside macrophages, which could contribute to immune evasion, antifungal resistance and potential recurrence of infection. asm.social/2Q2

Interaction of C. glabrata wild type and C. albicans yeast-locked efg1ΔΔ/cph1ΔΔ mutant cells with macrophages.
Microbial Pathogenicity Mechanisms@mpm-hki.bsky.social · 5mo ago

🎶Should I stay or should I go?🎶 Unlike other fungi, the pathogen C. glabrata delays its escape from immune cells. Our new @asm.org mBio study shows the kinase Ksp1 is key! Loss of Ksp1 leads to "petite" 🥺 variants that lack mitochondria—dodging both immunity & drugs! doi.org/10.1128/mbio...

“Should I stay or should I go”—a kinase delays escape of Candida glabrata from macrophages | mBio

Candida glabrata is a major cause of invasive candidiasis and is difficult to treat due to its intrinsic resistance to antifungal drugs and its ability to survive inside host immune cells. How this pathogen regulates its intracellular lifestyle and exit from macrophages remains poorly understood. We show that C. glabrata actively modulates its interaction with macrophages through the protein kinase Ksp1, which regulates mitochondrial dysfunction and the formation of respiration-deficient cells. These variants display enhanced resistance to two antifungal drugs and killing by phagocytes. Our findings suggest that prolonging the intramacrophage phase and generating stress-resistant variants are key components of C. glabrata’s survival strategy. Recognizing these processes has important implications for clinical diagnostics and the management of persistent and recurrent fungal infections.

doi.org

Leibniz-HKI@leibniz-hki.de · 6mo ago

What drives women in science — and how do they drive science forward? 🔬🚀 Great to see that @microverse.bsky.social has captured and shared the voices of women scientists for #InternationalDayOfWomenAndGirlsInScience, including colleagues from our institute.

Balance of the Microverse@microverse.bsky.social · 6mo ago

Different Roles, One Shared Mission! 🔬✨ Success in the Microverse Ecosystem is about more than just research—it's about the perspectives and support systems that empower women to lead. 🚀 Happy #InternationalDayOfWomenAndGirlsInScience! 🤝@leibniz-hki.de & @uni-jena.de

Leibniz-HKI@leibniz-hki.de · 9mo ago

📖 Perfect weekend reading for fungal fans! 😉 Our @mpm-hki.bsky.social colleagues uncover how #CandidaAlbicans manages to invade tissue as hyphae but spread as yeast. Published in @femsjournals.bsky.social. 🧑🏻‍🔬: @jlspragu.bsky.social

FEMS Journals@femsjournals.bsky.social · 9mo ago

#C.albicans invades tissues as hyphae but spreads as yeast, How? @jlspragu.bsky.social & coll. show yeast can reach the bloodstream by hitchhiking with invasive hyphae or by switching forms. 🧫 More clues for understanding systemic infections ! 👉 buff.ly/0vklJeb

SPP2225@spp2225.bsky.social · 10mo ago

Check out another brand-new publication by our EXIT members Theresa Lange, Bernhard Hube, and Sascha Brunke, together with additional co-authors, on #Candidaalbicans in PLOS Pathogens: dx.plos.org/10.1371/jour...

“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation

Author summary In this study, we set out to understand whether Candida albicans found in nature can be as dangerous as the strains collected from patients, and whether a diet high in sugar affects the...

dx.plos.org