Detection of Trichophyton indotineae using a species-specific genomic marker: a marker identification and assay validation study

OG7443 is a species-specific genomic marker for T indotineae that supports two assay formats. These assays could aid surveillance, case recognition, and triage for downstream resistance testing, but d...

thelancet.com

Robustness of Ancestral Sequence Reconstruction to Among-site and Among-lineage Evolutionary Heterogeneity

Abstract. Ancestral sequence reconstruction is typically performed using homogeneous evolutionary models, which assume that the same substitution propensit

academic.oup.com

Tree-killing beetle is spreading to urban forests around the world

As researchers piece together the pest’s global trek, countries are working to contain the growing threat

science.org

Micafungin exposure drives multidrug resistance in Clavispora lusitaniae

Fungal infections are an escalating global health concern, with rare Candida species posing an urgent threat due to emerging multidrug resistance. Clavispora ( Candida ) lusitaniae is an uncommon path...

biorxiv.org

Hidden Fungal DNA Structures May Shape Sequencing Outcomes

Sequencing fungal DNA presents numerous challenges, and unexplored structural anomalies may be a contributor. Native ONT sequencing allows artefacts of disrupted pore translocation to be interrogated...

onlinelibrary.wiley.com

Development and validation of the AURIS score for predicting candidaemia in Candidozyma auris-colonised patients in the intensive care unit: a bicentric retrospective cohort study

The AURIS score provides a pragmatic tool for risk stratification among C auris-colonised ICU patients, with value in identifying those at low risk of candidaemia, reducing unnecessary empirical antif...

thelancet.com

How to give a bad talk

Nature Reviews Cancer - Effective presentations require clarity and audience awareness. In this Comment, Itai Yanai outlines common misconceptions about presentations and how to address them to...

rdcu.be

Fred Hutch senior staff scientist honored by Genetics Society of America

Dr. Irini Topalidou, a senior staff scientist at Fred Hutch Cancer Center, is the first winner of the Genetics Society of America Mentorship Award who isn’t a principal investigator or faculty member....

fredhutch.org

Pulmonary Fungal Infections in the Immunocompetent Host

Pulmonary fungal infections, which have traditionally been associated with patients who are immunocompromised, are now increasingly recognized among immunocompetent individuals. This trend is attribut...

journal.chestnet.org

Life Identification Numbers: A strain nomenclature approach to aid epidemiological surveillance of bacterial pathogens

Unified bacterial strain taxonomies are needed for coherent communication of findings in microbiological research. This Essay provides an overview of a novel bacterial strain taxonomy and describes ho...

journals.plos.org

rdcu.be

Comparative mitogenomics of kingdom Fungi – evolutionary insights and metagenomic applications

Abstract. Mitochondria are essential components of eukaryotic cells, responsible for ATP production through oxidative phosphorylation. Despite their biolog

academic.oup.com

Treemble: a graphical tool to generate Newick strings from phylogenetic tree images

AbstractSummary. Phylogenetic trees are ubiquitous and central to biology, but most published trees are available only as visual diagrams and not in the ma

doi.org

Population genomics of yellow-eyed penguins uncovers subspecies divergence and candidate genes linked to respiratory distress syndrome - Nature Ecology & Evolution

Whole-genome data from 249 yellow-eyed penguins (hoiho) identify three lineages with high geographical and genomic divergence, and candidate gene variants associated with differential susceptibility to neonatal respiratory distress syndrome.

go.nature.com

Urosepsis by multidrug-resistant Nakaseomyces glabratus with non-functional Erg3 and Erg11—do collateral sensitivity and a unique mode of action make nitroxoline a viable UTI antifungal? | mBio

Evolutionary theory states that fitness determines survival. In a drug-treatment environment, resistance increases fitness, but it often comes at a cost, such as slower growth or reduced stress tolera...

journals.asm.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

Mating-type locus structure affects gene expression in unidirectional mating-type switching fungi

Abstract. Fungal species are typically either fully self-fertile or self-sterile, but some filamentous ascomycetes can transition from self-fertility to se

academic.oup.com

Updated Genomic Epidemiologic Description of <em>Candida (Candidozyma) auris</em>, United States

Genomic Epidemiologic Description of <em>C. auris</em>

wwwnc.cdc.gov

Gene duplication, horizontal gene transfer, and trait trade-offs drive evolution of postfire resource acquisition in pyrophilous fungi | PNAS

Wildfires significantly alter soil carbon (C) and nitrogen (N), reducing microbial richness and biomass, while selecting for &ldquo;fire-loving&rdquo; pyrophil...

pnas.org

How (not) to organise a panel at a global health conference

Global health is unfortunately not very global—a contradiction that becomes most evident at global health conferences. Although convened to advance the field of global health, these conferences often ...

thelancet.com

Global emergence and rapid spread of Candidozyma auris (syn. Candida auris): epidemiology, biology, and antifungal resistance | Clinical Microbiology Reviews

SUMMARYThe emerging fungal pathogen Candidozyma auris (syn. Candida auris; C. auris) has attracted considerable attention from the scientific, clinical, and public health communities due to its multid...

journals.asm.org

Rising Burden of Severe Pediatric Coccidioidomycosis: A 25-Year Single Center Study

Cases of pediatric coccidioidomycosis have been rising in incidence and severity at our children’s hospital in an endemic area since 2000, including a subs

academic.oup.com

biorxiv.org

Deciphering the multidrug resistance paradigm in Candida auris | Antimicrobial Agents and Chemotherapy

Candida auris (taxonomically reclassified as Candidozyma auris [1]) is often described as a paragon of antifungal resistance among fungal species. Like the related Candida haemulonii (reclassified as Candidozyma haemuli) complex members, C. auris demonstrates a notably high propensity for antifungal resistance compared to more commonly clinically isolated but genetically distant Candida species. As C. auris has emerged and become more commonly established, concerns around diminishing therapeutic options in an already limited arsenal of antifungal drugs have prompted substantial warnings from clinical and public health authorities (2–4). Our understanding of C. auris antifungal resistance is grounded in early studies that characterized the global spread of this pathogen (5, 6). While the numbers vary across regional reports, nearly 90% of clinical isolates are resistant to at least fluconazole, a widely administered triazole-class drug, while up to 30% of isolates are reportedly also resistant to a drug in at least one other antifungal class. Research in subsequent years has deeply investigated mechanisms and patterns in C. auris antifungal resistance, presenting the opportunity for reexamination to identify therapeutically useful insights (7–9).

journals.asm.org

Aquatic Bacterial Community Responses to Aquatic Contaminants Revealed by 16S rRNA Metabarcoding in Field‐Based Microcosms

This study used sedimentary eDNA analysis and field-based microcosms to assess the impacts of three major aquatic contaminants on bacterial assemblage structure. Our results showed significant but va...

enviromicro-journals.onlinelibrary.wiley.com

WHO assessment of the preclinical antifungal pipeline: evaluating innovation and preparedness in the face of emerging fungal threats

Life-threatening invasive and mucosal fungal infections are a major, increasingly complex global health problem. Among all population groups, individuals who are immunocompromised face the greatest ri...

thelancet.com