Very happy to see this story finally out (link in comments)! We used low-input Capture Hi-C to profile promoter-anchored chromosomal interactions in Type 3 innate lymphoid cells (ILC3s) - rare tissue-resident lymphocytes that lack antigen receptors and regulate barrier immunity.

MRC Laboratory of Medical Sciences@mrc-lms.bsky.social · yesterday

New research published today in Nature Genetics uses a technique called mini-Capture Hi-C to map 3D DNA folding in rare ILC3 immune cells, linking 100+ genes to immune disease risk in this cell type 🧬

New research published today in Nature Genetics uses a technique called mini-Capture Hi-C to map 3D DNA folding in rare ILC3 immune cells, linking 100+ genes to immune disease risk in this cell type 🧬

Mapping the 3D genome in rare immune cells reveals new genes linked with autoimmune disease risk

Researchers from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London, in collaboration with centres in Europe and the USA, have uncovered new genes linked to autoimmune conditions...

lms.mrc.ac.uk

Calling ambitious clinician scientists! Have an innovative research idea? The Chain Florey Advanced Postdoctoral Fellowship offers up to 24 months of protected research time, mentorship, and access to world-leading LMS expertise to help launch your path to research independence.

Chain Florey Advanced Postdoctoral Fellowship for Clinician Scientists - MRC Laboratory of Medical Sciences

lms.mrc.ac.uk

Our Director @wiebkearlt.bsky.social spoke at the opening of Pfizer's new London research centre (IMIC at Apex) this week, reflecting on decades of publicly-funded UK discovery science in obesity and cardiometabolic research and on the importance of long-term academic-industry collaboration 🧬

LMS Director speaks at opening of Pfizer's new London research centre

Professor Wiebke Arlt, Director of the Medical Research Council Laboratory of Medical Sciences (MRC LMS), spoke at the opening of Pfizer's new London research centre, reflecting on decades of publicly...

lms.mrc.ac.uk

A new study maps where dormant cancer cells hide in breast tumours: tucked into neighbourhoods of immune + support cells that may shield them from treatment. Understanding these hideouts could lead to new drug targets🧬 @mrc-lms.bsky.social @imperialmed.bsky.social @ucl.ac.uk

Scientists map dormant cancer cells' hideouts, opening new targets for treatment

Researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and UCL Genetics Institute have created a detailed map of cells within breast tumours and identified distinct neigh...

lms.mrc.ac.uk

New paper out in Nature Communications! 🥳🧬🔬 We map the earliest DNA strand separation during MCM2-7 helicase activation at near base-pair resolution, revealing where origin melting begins and how DNA is routed through the Mcm2/5 gate. doi.org/10.1038/s414... #DNAReplication

New research has uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy of its genome. The findings reveal where DNA first starts to "unzip" inside living cells and identify a molecular gate that helps prepare DNA for copying.

Scientists pinpoint where cells first begin copying DNA

Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy ...

lms.mrc.ac.uk

We won the 2026 Provost’s Award for Excellence in Animal Research (Engagement) for our Animal Research Corner activity! Part of the LMS Gene Home at Great Exhibition Road Festival in 2025, this activity gave visitors the chance to explore the role of animals in medical research.

National research institutes are vital to the UK's research landscape. This month, the National Research Organisations (NRO) Group launched, bringing together 40+ organisations, including the LMS. Together, we'll help strengthen UK research and maximise its impact for patients and society.

UK’s world-class research organisations launch new collective with LMS as a proud member

The National Research Organisations (NRO) Group officially launched this month. A first of its kind collective for the UK, the NRO brings together more than 40 of the UK's national science and researc...

lms.mrc.ac.uk

We’re delighted to welcome Dr CK Wong to the MRC Laboratory of Medical Sciences as Head of the Endocrine Signalling in Inflammation Group. Read more about CK’s research, what inspires his work and why he joined the LMS below 👇 #MedicalResearch #Inflammation #GLP1 #Endocrinology

Dr CK Wong joins the LMS as Head of the Endocrine Signalling in Inflammation Group

We’re delighted to welcome Dr CK Wong, who joins the MRC Laboratory of Medical Sciences (LMS) this month as Head of the Endocrine Signalling in Inflammation Group. His research explores how gut hormon...

lms.mrc.ac.uk

Fundamental research can have impact far beyond its original application. Congratulations to Myricx Bio and @imperialcollegeldn.bsky.social on their acquisition by @novartis.bsky.social.

Imperial cancer therapy spinout and LMS collaborator Myricx Bio agrees to be acquired by Novartis

Myricx Bio, a cancer therapy spinout from Imperial’s Department of Chemistry that has collaborated with researchers at the MRC Laboratory of Medical Sciences (LMS) since 2020, has announced it has rea...

lms.mrc.ac.uk

13.5% of young people are not in work or education. That's why we’ve teamed up with @youthcareers.bsky.social to launch 1:1 mentoring as part of our Pathways Programme! This scheme matches 16-17-year-olds with our staff, helping them build confidence and develop employability skills.

📢 Applications are open for our Science Technology Graduate Programme! We're looking for recent graduates (with no postgraduate degree) to join our Proteomics and Metabolomics facilities. If you're looking to gain experience in research, we'd love to hear from you. 🗓️ Applications close 9 August.

Science technology graduate programme

Our Graduate Programme develops fresh science graduates into highly sought after technicians.

lms.mrc.ac.uk

3Rs leaflets are available to engage public audiences about efforts to replace, reduce and refine animal use in research: nc3rs.org.uk/3rs-resource... Created by Dr Yu Liu @mrc-lms.bsky.social with the support of the NC3Rs Communications Team and funding through our public engagement award scheme.

Congratulations to Dr Lara Curran on being awarded a 4-year Clinical Early Career Research Fellowship from the British Heart Foundation!🫀 Lara will investigate how advanced cardiac imaging, genetics & machine learning can improve risk prediction in hypertrophic cardiomyopathy. @thebhf.bsky.social

Dr Lara Curran awarded BHF Fellowship for research into inherited heart condition

Dr Lara Curran, a clinician scientist and cardiology trainee at the MRC Laboratory of Medical Sciences (LMS), has been awarded a Clinical Early Career Research Fellowship from the British Heart Founda...

lms.mrc.ac.uk

‪ Archaea are the hornets of the microbial world. Discuss. www.biorxiv.org/content/10.6... TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.

G0 or no-G0, if you’re interested in learning the role of phosphatases in regulating quiescence and cell cycle entry read this new review by Robinson & Barr published in #BiochemSocTrans https://doi.org/10.1042/BST20250091 🧪

Our fantastic PhD student, Ellie Robinson, wrote this in-depth review on phosphatases in quiescence entry, maintenance & exit. "This is an important & timely review for the field" Reviewer 1 😍 First of many articles to come from Ellie! @mrc-lms.bsky.social @imperialcollegeldn.bsky.social

Biochemical Society@biochemsoc.bsky.social · 2mo ago

G0 or no-G0, if you’re interested in learning the role of phosphatases in regulating quiescence and cell cycle entry read this new review by Robinson & Barr published in #BiochemSocTrans https://doi.org/10.1042/BST20250091 🧪

A new study tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development and highlights how the genome’s 3D structure helps shape cell identity and could offer clues to how developmental disorders arise 🧬

3D genome architecture pre-wires early developmental decisions

New research tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development. The study reconstructs a timeline of chromosome folding tha...

lms.mrc.ac.uk

What does healthy eating mean to you? 🌱🧬 Over the last few months, we’ve been co-designing new activities for the LMS Gene Home – our immersive exhibition exploring how genes impact health, which returns to @imperialcollegeldn.bsky.social’s @exrdfestival.bsky.social l this year.

We're looking for a new Roving Research @mrc-lms.bsky.social A unique post for those who love research, learning new techniques & working across different teams. Must be a great communicator & well organised! Apply by 21 June: fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...

Investigator Scientist Roving Researcher

Investigator Scientist (Roving Researcher) (LMS 2369) Salary £42,159 – 44,801 plus London Allowance (£5,560) per annum | 2 years fixed term | Full time | Closing Date: 21 June

fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com

Congratulations to our Imperial researchers who have been elected Fellows of the @acmedsci.bsky.social! 🎉🎊 From infectious disease and addiction, to vaccines and dementia, their work is shaping the future of #healthcare. www.imperial.ac.uk/news/article... #MedicalScience #Research

Seven Imperial professors elected Fellows of the Academy of Medical Sciences

Imperial researchers working across infectious disease, genomics, neuroscience and cardiovascular medicine are among those recognised in this year&rs...

imperial.ac.uk

Congratulations to Professor James Ware on being elected a Fellow of the Academy of Medical Sciences! James was recognised for internationally leading contributions to cardiovascular genomics & precision medicine, advancing understanding and care for inherited heart disease 🫀

We’re recruiting two Postdoctoral Researchers to join the Endocrine Signalling in Inflammation Group at the LMS! 🔬 Postdoctoral Research Scientist in Immunometabolism 🧠 Postdoctoral Research Scientist in the Gut–Brain–Immune Axis Visit our website to find out more ⬇️

Vacancies at the LMS

View all the current vacancies at the MRC Laboratory of Medical Sciences, including research, technician, and support roles and jobs.

lms.mrc.ac.uk

This year, we were delighted to partner with the @acmedsci.bsky.social to host CATAC at the LMS. The conference created a supportive space for clinical academics in training to share their research, build confidence, and connect with peers across disciplines.

Congratulations Melanie Chan on being awarded an MRC Clinician Scientist Fellowship to advance research into rare kidney disease! She plans to investigate conditions like CAKUT – a leading cause of kidney failure in children – to better understand why disease severity varies between patients.

Dr Melanie Chan receives prestigious MRC Clinician Scientist Fellowship to research rare kidney disease

Dr Melanie Chan, a Transition-to-Independence Fellow in the Chain Florey Programme at the MRC Laboratory of Medical Sciences (LMS), has been awarded a highly competitive five-year MRC Clinician Scient...

lms.mrc.ac.uk

Great to bring together researchers from the UK, Nordics & Korea for the “Immune System for Physiology and Pathology” workshop at LMS. Part of our Team Science initiative, the day highlighted the power of collaboration in tackling complex immunology challenges. #TeamScience #ResearchCollaboration

Are you in human physiology and thinking about starting your own research group? This is a great chance to take that next step at the LMS! 👇 📅 Deadline: 4 May Please share with anyone who might be interested! #HumanPhysiology #AcademicJobs #ResearchCareers #STEM

Programme Leader Track - MRC Laboratory of Medical Sciences

lms.mrc.ac.uk

Congratulations to the whole team - happy that @gruevska.bsky.social and I could play a small part in this exciting study!

MRC Laboratory of Medical Sciences@mrc-lms.bsky.social · 3mo ago

New LMS research has identified a set of drugs that could exploit a recently-revealed weakness in ‘zombie-like’ – or senescent – cells and could lead to new treatments for cancer and age-associated diseases. @ukri.org @cancerresearchuk.org @mrc-lms.bsky.social @imperialmed.bsky.social

Today (24 April) marks World Hormone Day – a moment to raise awareness of hormones and why they matter for our health. #BecauseHormornesMatter #WorldHormoneDay