Lab artists go the Art Gallery of Ontario! - Jul 2026
Miguel Ramalho-Santos
@mrsantos.bsky.social
Scientist and Professor in Developmental Epigenetics. Lunenfeld-Tanenbaum Research Institute Dpt Molecular Genetics, University of Toronto, Canada Lab: mrsantoslab.org Coimbra, Portugal -> Cambridge, MA, USA -> S. Francisco, CA, USA -> Toronto, ON, Canada
Congratulations to our Lab PhD student on successfully passing the PhD defense on June 22, 2026! Your dedication, perseverance, and commitment have culminated in this remarkable achievement. Wishing you continued success in the next chapter of your career. Congratulations, Dr.Andrew!
Discussed @mrsantos.bsky.social lit review: Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice. www.nature.com/articles/s41...
Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice - Nature Communications
The authors develop a system to erase DNA methylation at H19-DMR in mouse sperm. Despite loss, methylation partly recovers via H3K9me3 after fertilization, revealing partial intergenerational epigenet...
nature.com
Love the smell of "accepted in principle" in the (Monday) morning...
Discussed @mrsantos.bsky.social lit review: Nascent transcriptome of embryonic genome activation reveals a regulatory axis linking transcriptional priming to early lineage specification in mouse embryos. academic.oup.com/nar/article/...
Nascent transcriptome of embryonic genome activation reveals a regulatory axis linking transcriptional priming to early lineage specification in mouse embryos
Abstract. Embryonic genome activation (EGA) marks a critical developmental transition, yet its regulatory architecture remains incompletely defined. Here,
academic.oup.com
In our latest anti-bias lab meeting, we discussed the global impacts for societies and scientific research of the blockade of the Strait of Hormuz arising from the war of US and Israel with Iran.
Discussed @mrsantos.bsky.social lit review: Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters. onlinelibrary.wiley.com/doi/10.1002/...
Live‐Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters
The intracellular delivery of trans-cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron-demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro)...
onlinelibrary.wiley.com
Discussed @mrsantos.bsky.social lit review: Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet induced insulin dysregulation and obesity. rdcu.be/e910l
Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity
Nature Communications - Gestational exposure of mice to the obesogen tributyltin alters 3-D chromatin interactions in primordial germ cells leading to stable reduction of hepatic Ide expression and...
rdcu.be
Great work by Brandon Cho, our fantastic student-turned-postdoc, out now in Oncogene. Great collaboration w Linda Penn (Toronto). We put the chromatin remodeller CHD1 in an "epistasis battle" with overexpression of THE oncogene MYC in a breast cancer model. 1/2 www.nature.com/articles/s41...
CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer - Oncogene
Oncogene - CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer
nature.com
Really proud of our stellar lab manager, Kirti Mittal! 1st author in a paper out in @genesdev.bsky.social. From chromatin-bound RNA to functional studies in human ESCs, she discovered a new role for alpha-satellite repeats in nuclear compartmentalization. Congrats! pubmed.ncbi.nlm.nih.gov/41730687/
Discussed @mrsantosny.bsky.social lit review: Stress controls heterochromatin inheritance via histone H3 ubiquitylation. www.nature.com/articles/s41...
Stress controls heterochromatin inheritance via histone H3 ubiquitylation - Nature
A histone ubiquitin-dependent regulatory hub governs stimulus-dependent heterochromatin propagation, with important implications for understanding mechanisms governing rapid changes in the epigen...
nature.com
Discussed @mrsantos.bsky.social lit review: Cell-type-specific RNA polymerase II activity maps in intact tissues provide a gateway to mammalian gene regulatory mechanisms in vivo. www.cell.com/developmenta...
Cell-type-specific RNA polymerase II activity maps in intact tissues provide a gateway to mammalian gene regulatory mechanisms in vivo
Chovatiya et al. developed PReCIS-seq, an in vivo approach that maps transcriptionally engaged RNA polymerase II in Cre-targeted cells within intact mouse tissues, without cell isolation. They report ...
cell.com
Discussed @mrsantos.bsky.social lit review: Stabilizing a mammalian RNA thermometer confers neuroprotection in subarachnoid hemorrhage. www.nature.com/articles/s41...
Stabilizing a mammalian RNA thermometer confers neuroprotection in subarachnoid hemorrhage - Nature Communications
Here the authors identify RNA G-quadruplexes as temperature-sensitive regulators of alternative splicing and gene expression, opening potential therapeutic avenues such as neuroprotection with potassi...
nature.com
Discussed @mrsantos.bsky.social lit review: Analog epigenetic memory revealed by targeted chromatin editing. www.sciencedirect.com/science/arti...
Analog epigenetic memory revealed by targeted chromatin editing
Cells store information by means of chromatin modifications that persist through cell divisions and can hold gene expression silenced over generations…
sciencedirect.com
Discussed @mrsantos.bsky.social lit review: Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells. www.biorxiv.org/content/10.1...
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
Acquisition of specific cell shapes and morphologies is a central component of cell fate transitions. Although signaling circuits and gene regulatory networks that regulate pluripotent stem cell diffe...
biorxiv.org
Discussed @mrsantos.bsky.social lit review: Preventing CpG hypermethylation in oocytes safeguards mouse development. www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b knockout embryos die dur...
cell.com
(1/4) New Pre-print! 🌟 Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
The ISSCR is seeking nominations for Vice President and three Director positions. This is an opportunity to help shape the future of stem cell research and contribute to a global scientific community. Nominations are due 22 October 2025. Learn more 👉 https://www.isscr.org/nominations
2026 Election Nominations — International Society for Stem Cell Research
Elections and nominations for the International Society for Stem Cell Research board of directors and officers.
isscr.org
John Gurdon was a true giant: - founder of cell reprogramming; - founder of molecular embryology; - unabashed advocate for basic research; - advisor to numerous successful trainees/PIs; - gentle human that touched so many. In dark times with science under attack, let his vision be a guiding light.
Katherine Brown@katherine-brown.bsky.social · 10mo agoVery saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.
🚨 JOB ALERT 🚨 We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. Apply now or repost!
Research at Sinai Health@sinaihealth.bsky.social · 11mo agoJob Alert 🚨 Are you an emerging leader in biomedical discovery or population health data science? We are looking for outstanding candidates to join our institute! Learn more & apply: Biomedical Discovery ➡️ apply.interfolio.com/172703 Population Health Data Science ➡️ apply.interfolio.com/172529
Thank you for this honor and the continued trust in our group's research! We hope that our work will honor the memory and legacy of Anne and Max Tanenbaum. It is truly a privilege to be part of the amazing communities of @uoftmedicine.bsky.social and @sinaihealth.bsky.social.
Research at Sinai Health@sinaihealth.bsky.social · 12mo agoCongratulations to Dr. Miguel Ramalho-Santos, Senior Investigator at the Lunenfeld-Tanenbaum Research Institute, on his appointment as the Anne & Max Tanenbaum Chair of Molecular Medicine at Sinai Health!
(1/4) New preprint from the lab! The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer
The MYC transcription factor is a key regulator of growth during development and a potent cancer driver when its expression is dysregulated. Strategies to inhibit MYC oncogenic activity would mark a s...
biorxiv.org
Discussed @mrsantos.bsky.social lit review: A single-cell time-lapse of mouse prenatal development from gastrula to birth. www.nature.com/articles/s41...
A single-cell time-lapse of mouse prenatal development from gastrula to birth - Nature
Single-cell transcriptome profiling of mouse embryos and newborn pups is combined with previously published data to construct a tree of cell-type relationships tracing development from zygote to birth...
nature.com
Discussed @mrsantos.bsky.social lit review: Recovering undersampled single-cell transcriptomes with HyperCell. www.researchsquare.com/article/rs-6...
Recovering undersampled single-cell transcriptomes with HyperCell
Single-cell transcriptomic technology has now matured, allowing quantification of mRNA transcripts corresponding to tens of thousands of genes within a cell. However, still only a small fraction of th...
researchsquare.com
(1/3) Latest preprint from the lab! 📝 This work points towards regulatory roles of alpha satellite RNA in nuclear compartmentalization and tuning ribosomal RNA expression in naïve human embryonic stem cells. doi.org/10.1101/2025...
Alpha satellite RNA marks the perinucleolar compartment and represses ribosomal RNA expression in naïve human embryonic stem cells
While most newly synthesized RNA is exported to the cytoplasm, a portion of non-coding RNA is retained in the nucleus and remains highly associated with chromatin. The strong binding of this RNA fract...
doi.org
⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference! 🧪Share your exciting discoveries with us!! 📍Malta 🗓️Talk Deadline: July 10 🔗http://bit.ly/49sCfJp @joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
Maria Alcolea@mariapalcolea.bsky.social · last yr.One Month to Go!🚨 Countdown for the STEM CELLS & CANCER Fusion Conference — a unique gathering of global leaders sharing their ground breaking research. 🧬Ignite new ideas by Mediterranean Sea-Malta 🏝️ 📅Final Deadline: 31 July 🎤Unmissable speakers...🧵 bit.ly/49sCfJp
Discussed @mrsantos.bsky.social lit review: Maternal iron deficiency causes male-to-female sex reversal in mouse embryos www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature
Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
nature.com