Mattias Siljestam

@msiljestam.bsky.social

Postdoc working with mathematical models of evolution. Dept of Ecology, Environment and Plant Sciences, Stockholm University

Eco-evolutionary model showing that heterozygote advantage can explain the extraordinary diversity of immune genes! Our new paper (out in #eLife: doi.org/10.7554/eLif...) identifies the conditions under which heterozygote advantage can drive the evolution of such diversity, found in e.g. #MHC genes

Heterozygote advantage can explain the extraordinary diversity of immune genes

An eco-evolutionary model shows that heterozygote advantage can maintain over 100 major histocompatibility complex alleles, providing a potent explanation for extraordinary immune gene diversity and c...

doi.org