Relieved to finally post my whole developing brain evolutionary "theory of everything" preprint! www.biorxiv.org/content/10.1...

ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain

Diverse neurons and glia are generated in conserved spatial and temporal sequences during mammalian brain development. Divergence in gene regulatory networks can alter brain composition, scaling, timi...

biorxiv.org

This is also what it's like to finish a cortical layer dissection...

TAHK0@tahk0.bsky.social · 12mo ago

this is the happiest a video game has ever been

Very proud of two new preprints from the lab: 1) CREsted: to train sequence-to-function deep learning models on scATAC-seq atlases, and use them to decipher enhancer logic and design synthetic enhancers. This has been a wonderful lab-wide collaborative effort. www.biorxiv.org/content/10.1...

CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species

Sequence-based deep learning models have become the state of the art for the analysis of the genomic regulatory code. Particularly for transcriptional enhancers, deep learning models excel at decipher...

biorxiv.org

What a robust and slightly threatening solution for demuxing, doublet detection,etc for multiplex single cell genomics experiments!

Nathan Schaefer@nkschaefer.bsky.social · last yr.

Picture this: you are running a single cell sequencing experiment and want to incorporate cells from different species, individuals, and maybe even perturbations. You process everything together to save time while reducing batch artifacts. You collect data. What do you do now?

Wanna save the taxpayer money? Don’t buy any Teslas.

Kendra "Gloom is My Beat" Pierre-Louis@kendrawrites.com · last yr.

Apparently Tesla isn't selling any cars which also means it's not selling carbon credits. It made 2.7 billion in carbon credits last year. Carbon credits is largely what has kept the company afloat

Pleasure to co-edit this issue of Current Opinion on human genetic origins with @steinlab.bsky.social: www.sciencedirect.com/special-issu...

Amidst the chaos, my partner was featured in this WaPo article about one more way that the administration is undermining the future of American Government www.washingtonpost.com/politics/202... So that's kinda fun right? 🥲😭

We need to make sure that everyone understands how important science is for EVERYONE not just for scientists...

Colette Delawalla, PhD@cdelawalla.bsky.social · last yr.

Get in dorks, we're going protesting! STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025 WASHINGTON DC AND EVERY STATE CAPITOL Because science is for everyone! Find us at www.standupforscience2025.org #standupforscience2025 #scienceforall #sciencenotsilence

We know by looking at the demographics of STEM faculty the system is biased against all sorts of people. With the murder of diversity supplements etc, what are we doing as a field to ensure a future of diverse people and ideas in science?

Jeremy Berg@jeremymberg.bsky.social · last yr.

“What this does is discriminate against people who are underrepresented,” The reviewer added that evaluation for the general and diversity pools are the same. “I can’t stress enough that an undeserving grant “is not going to get funded, whether it’s diversity or not” www.nytimes.com/2025/02/22/s...

@chanzuckerberg.bsky.social why? If you're mostly privately funded, why would you make it your choice to join the segregationists? Please walk it back-back and reinstate your DEI programs. www.theguardian.com/technology/2...

First post on this platform 👋. Glad to reconnect with old friends, and also learn from new contacts. Will post about intersecting themes: human evolution, genetics (esp. aDNA), neuroscience & cognition. Currently focusing on brain organoids and early developmental changes that may have had an impact

Who knew hyenas were feliforms?! I always had them pegged for canidae 🧪 (phylogeny from carnivoran Wikipedia)