This week in Nature Neuroscience: our study links “foamy” GPNMB⁺ microglia/macrophages, oxylipins and lipid metabolism to lesion expansion and faster progression in multiple sclerosis. MAGL emerges as a potential therapeutic target www.nature.com/articles/s41...

Foamy microglia link oxylipins to disease progression in multiple sclerosis - Nature Neuroscience

Foamy microglia are associated with multiple sclerosis progression, linking phagocytosis, altered lipid metabolism (oxylipins) and lysosomal stress to nonclassical neuroinflammation and disease severi...

nature.com

Heading home after a fantastic cannabinoid GRC meeting organised by @drjkhokhar.bsky.social and Cecilia Hillard. Hope to see you all in Dijon ICRS-meeting June 28th -July 2nd, 2026 @icrsonbluesky.bsky.social

It also highlights work by the group of @mvdstelt.bsky.social of the @led3hub.bsky.social on profiling the targets of BIA 10-2474 (www.science.org/doi/10.1126/...) as well as the work that @mads-chem.bsky.social performed in Ben Cravatt's lab on JAK1 inhibitors (www.nature.com/articles/s41...) (4/5)

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

A drug that was unexpectedly neurotoxic in a clinical trial has off-target activities in chemical proteomic assays.

science.org

A new exciting article in @natbiotech.nature.com highlights the power of chemical proteomics to find druggable pockets on difficult high-value targets. Great insights into applications in covalent and non-covalent drug discovery including clinical development. (1/5) www.nature.com/articles/s41...

Probing the proteome - Nature Biotechnology

Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?

nature.com

A great talk by Joel Rüegger of the group of @mvdstelt.bsky.social at #FocusOnCovalentDrugs. He talked about his amazing work in the @led3hub.bsky.social on the CellEKT platform for profiling target engagement of kinase inhibitors in living cells. (1/5) www.mcponline.org/article/S153...

Lipidation of proteins has diverse essential roles in biology. In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5) #chemsky #ChemBio

Another “Continuing Crisis” post, this one covering some larger principles and explaining why I’m doing these in general:

The Continuing Crisis, Part VII: An Overview

science.org

Happy to announce on my first bsky post that today our manuscript “The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles” has been published in its final form in PNAS n/1