❓ What are the health impacts of weight regain immediately prior to pregnancy or in early pregnancy? How do we maximize benefits while mitigating risks? Limited and conflicting data exist. pubmed.ncbi.nlm.nih.gov/42083106/ 📖 Read our perspective newly published in Obesity.

Glucagon-Like Peptide-1 Receptor Agonists: Considerations for Treating Preconception Obesity - PubMed

Glucagon-Like Peptide-1 Receptor Agonists: Considerations for Treating Preconception Obesity

pubmed.ncbi.nlm.nih.gov

In new clinical guidance, @endosocjournals.bsky.social says Lancet Commission work on #ClinicalObesity is a meaningful advance, but has practical issues. Lancet author Francesco Rubino says they're mistaken. Dialogue & collab needed. HT: @mweintraubmd.bsky.social conscienhealth.org/2026/04/06/u...

💉 In a large real-world study, tirzepatide was associated with a lower incidence of major cardiovascular outcomes vs semaglutide: 📊 Composite CV outcome: 1.90% vs 2.18% (HR 0.86, p=0.01) ❤️ New-onset heart failure: 1.04% vs 1.29% (HR 0.79, p=0.002) dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1...

⚖️ The Commission made a genuine advance, moving beyond BMI toward a more nuanced, adiposity-based diagnosis. But does the framework hold up under scrutiny?

Ranganath Muniyappa@muniyappar.bsky.social · 6mo ago

New Endocrine Society guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy. Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...

Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts www.statnews.com/2026/04/02/b... via @statnews.com

Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts

A new way to define obesity aims to sharpen the diagnosis. Critics warn it could delay care, exclude diabetes, and deepen inequities in accessing treatment.

statnews.com

New Endocrine Society guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy. Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...

Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework

Abstract. The Lancet Diabetes & Endocrinology Commission undertook the complex task of addressing limitations in existing definitions and classificatio

academic.oup.com

Today the FDA approved the first once-weekly insulin. Insulin icodec, now brand name Awiqli, demonstrated superior a1c reduction to daily insulin glargine with a1c reduction of 1.55% compared to 1.35%, in addition to 6 less injections per week in the ONWARDS phase 3 trial.

You know the protein craze is getting too much when protein-infused Pop Tarts are on the shelves. conscienhealth.org/2026/02/23/m...

There are multiple methods to estimate body composition, each with their pros and cons. www.mdpi.com/2075-1729/14...

DEXA-derived estimates of abdominal adiposity in postmenopausal women was a better predictor of cardiometabolic disease than traditional surrogates (BMI, waist circumference, waist-to-hip ratio) in older women. pubmed.ncbi.nlm.nih.gov/34479738/

DXA Versus Clinical Measures of Adiposity as Predictors of Cardiometabolic Diseases and All-Cause Mortality in Postmenopausal Women - PubMed

DXA-derived estimates of abdominal adiposity in postmenopausal women may allow for substantially improved risk prediction of diabetes over standard clinical risk models. Larger DXA studies with…

pubmed.ncbi.nlm.nih.gov

CagriSema demonstrates a1c reduction of 1.9% and weight loss of 14.2% in adults with type 2 diabetes, reported from the REIMAGINE 2 top-line data this week.

Automated insulin delivery, the integration of insulin pump with continuous glucose monitor is now the standard of care for Type 1 Diabetes 🤖💉📈 Why? It’s clearly superior in attaining greater diabetes control by way of Time In Range ⏱️🩸✅ researchprofiles.ku.dk/en/publicati...

Milestones in research related to the pathophysiology of the incretin hormones GIP and GLP-1 as parent compounds for incretin-based medications for treatment of type 2 diabetes and clinical obesity pubmed.ncbi.nlm.nih.gov/41547366/

What's new in ADA Standards of Care 2026? Inclusion of continuous glucose monitoring (CGM) data when monitoring for disease progression among individuals with presymptomatic type 1 diabetes. Recommendation 3.2 ADA Standards of Care 2026 diabetesjournals.org/care/article...

Mild autonomous cortisol secretion (MACS) is not a benign condition. MACS carries increased risk of mortality with HR 1.52-1.77 compared to those with non-functioning adenomas, with death from cardiovascular disease, cancer and infection.

How to manage Post-Bariatric Hypoglycemia (BPH), according to a new consensus statement

Mild autonomous cortisol secretion (MACS) traditionally viewed as part of the continuum of Cushing syndrome is recognized as a distinct entity. Only <1% of MACS processes to overt Cushing syndrome. Genetic mutations for MACS and Cushing syndrome is different www.vumedi.com/video/when-a...

Anabolic therapies hold tremendous potential for the treatment of osteoporosis. 💪🦴 Currently all treatments are injectables, but the are oral options on the horizon. 💉➡️💊 pubmed.ncbi.nlm.nih.gov/38578978/

A practical side-by-side comparison of the Tymlos and Forteo, the two anabolic PTH receptor agonists for osteoporosis. Presented by Dr. Bilezikian

In a world where a publication becomes outdated immediately after it's published, a recent systemic review shows incretin-based medications dominate clinical trial development. But they are not the only potential mechanism. pubmed.ncbi.nlm.nih.gov/40993341/

We should be screening everyone with hypertension for primary aldosteronism, according to the recently released Endocrine Society guidelines. Follow this diagnostic algorithm Full guidelines: academic.oup.com/jcem/article...

How to individualize obesity medication treatment depending on obesity-related conditions. Great summary by the newly released update to the AACE Evaluation and Treatment of Adults with Obesity 2025 Consensus Statement www.endocrinepractice.org/article/S153...

Developing clinical practice guidelines is quite a process. The GRADE format methodology translates evidence to medication decision-making recommendations after performing systemic review of the available evidence. www.bmj.com/content/389/...

A higher BMI is correlated with increased risk of overall mortality. It follows the same overall curve as higher cholesterol and blood pressure, as illustrated in these graphs 📈 Controlling any and all of these risk factors lowers our overall risk of death. pubmed.ncbi.nlm.nih.gov/28489290/

Obesity rates have skyrocketed starting in the 1970s now reaching 40% in the United States. "It seems highly unlikely that the obesity epidemic can be explained by a widespread drop in willpower happening in the late 1970s." www.cell.com/cell/fulltex...

A collection of all my favorite podcasts to stay up to date in Diabetes Care Check out this Marvel-style crossover episode hosted at ADA. overcast.fm/+AABFhuN39pM

Special Edition - ADA Scientific Sessions 2025 — Diabetes Core Update

In this special edition of Diabetes Core Update we present a special podcast recorded live at the ADA Scientific Sessions by the editors of Diabetes Core Update, Diabetes Care On Air, Diabetes Bio,…

overcast.fm

Rates of obesity of BMI 30-40 have had a mild increase over the last 20 years. Rates of severe obesity BMI > 60 has dramatically risen- this graph is impressive. Slide by Dr. Satya Dash at #ENDO2025

Pheochromocytoma survival curves are dismal, particularly in those with metastatic disease. We need better treatments for these patients. Excellent lecture by Dr. Camilo Jimenez at #ENDO2025

Multiple benefits of GLP1s in reducing residual risk in those with type 1 diabetes. Excellent talk by Dr. Kaitlin Love at #ENDO2025

GLP1 agonism prevents cardiovascular disease through both direct and indirect vascular effects #ENDO2025