Ranganath Muniyappa
@muniyappar.bsky.social
Senior Clinician and Endocrinologist NIDDK with an interest in diabetes, obesity, and cardiovascular disease. Views/comments my own.
Shocked why?
Apoorva Mandavilli@apoorvanyt.bsky.social · 2w agoI’ve been reporting on the CDC for years, and have written about many of its troubles over the past year. I was still shocked by the extent of the staff losses and political interference I found when reporting this one. www.nytimes.com/2026/09/26/h...
Challenged by the complexity of explaining GLP-1 medicines to friends and family? Gustav Hållén the talented producer of Zero Order has figured it out. Have a listen www.youtube.com/watch?v=VCIW...
I reviewed On the Future of Species by Adrian Woolfson for @thelancet.com. Adrian has now responded to my review here. www.thelancet.com/journals/lan...
On the computability of biological machines
In the book Natural Theology (1802), the English philosopher and theologian William Paley argued that the complexity of an organism, similar to that of a watch, implied the handiwork of a designer.1 H...
thelancet.com
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts www.statnews.com/2026/04/02/b... via @statnews.com
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts
A new way to define obesity aims to sharpen the diagnosis. Critics warn it could delay care, exclude diabetes, and deepen inequities in accessing treatment.
statnews.com
Guideline communication raises concerns on Lancet obesity report
New Endocrine Society guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy. Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...
Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework
Abstract. The Lancet Diabetes & Endocrinology Commission undertook the complex task of addressing limitations in existing definitions and classificatio
academic.oup.com
no quarter can or should be given to hold this evil to account
Investigative Post@ipostnews.bsky.social · 8mo agoBreaking: IPost has obtained CCTV footage showing a Border Patrol van dropping off Nurul Shah Alam at a closed Tim Hortons last Thursday. Shah Alam, nearly-blind & unable to enter the shop, then wandered the city for days. He was found dead Tuesday. www.investigativepost.org/2026/02/26/t...
I feel like reading the news should now come with a trigger warning. The degree of sociopathy and deceit on display by ICE agents is astounding and in any normal civil society would lead to multiple arrests at all levels of this despotic organization. And these are only the cases we know about…
Studies in mice demonstrate the importance of glutamatergic neurons in GPR75’s regulation of food intake and protection from #obesity www.cell.com/cell-reports...
GPR75 in glutamatergic neurons regulates body weight
Wyler, S.C. et al. identify a critical neuronal population that is required for GPR75 to exert its obesogenic effects using targeted deletion and reactivation of Gpr75 in glutamatergic neurons.
cell.com
The danger of superhuman AI is not what you think. This essay in @noemamag.com by @shannonvallor.bsky.social is brilliant. Well worth a read. www.noemamag.com/the-danger-o...
The Danger Of Superhuman AI Is Not What You Think | NOEMA
The rhetoric over “superhuman” AI implicitly erases what’s most important about being human.
noemamag.com
This is the essence of being an American. That is why we can not give up the fight to preserve and protect American values.
Aaron Rupar@atrupar.com · 8mo agoKatyal: "I was able to go to court - the son of immigrants-- & say on behalf of small businesses, 'Hey, this president is acting illegally.' I was able to present my case, have them ask really hard questions, & at the end of it they voted & we won. That is something extraordinary about this country"
My quote of the day A journey is a person in itself; no two are alike. And all plans, safeguards, policing, and coercion are fruitless. We find that after years of struggle that we do not take a trip; a trip takes us. John Steinbeck
Neal Katyal: "In America, the chief justice said only Congress can impose taxes on the American people, and that's what tariffs are. Tariffs are taxes."
well said - indeed a peer review system in crisis hard to find someone to review burden of review duplication and waste misuse/corruption of peer review www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News #NephSky
this isn't my faith tradition, but the idea that you are duty-bound to help others resonates with me it's a sin to walk past, never mind to exploit the victim further
![The Parable of the Good Samaritan
25 On one occasion an expert in the law stood up to test Jesus. “Teacher,” he asked, “what must I do to inherit eternal life?”
26 “What is written in the Law?” he replied. “How do you read it?”
27 He answered, “‘Love the Lord your God with all your heart and with all your soul and with all your strength and with all your mind’[a]; and, ‘Love your neighbor as yourself.’[b]”
28 “You have answered correctly,” Jesus replied. “Do this and you will live.”
29 But he wanted to justify himself, so he asked Jesus, “And who is my neighbor?”
30 In reply Jesus said: “A man was going down from Jerusalem to Jericho, when he was attacked by robbers. They stripped him of his clothes, beat him and went away, leaving him half dead. 31 A priest happened to be going down the same road, and when he saw the man, he passed by on the other side. 32 So too, a Levite, when he came to the place and saw him, passed by on the other side. 33 But a Samaritan, as he traveled, came where the man was; and when he saw him, he took pity on him. 34 He went to him and bandaged his wounds, pouring on oil and wine. Then he put the man on his own donkey, brought him to an inn and took care of him. 35 The next day he took out two denarii[c] and gave them to the innkeeper. ‘Look after him,’ he said, ‘and when I return, I will reimburse you for any extra expense you may have.’
36 “Which of these three do you think was a neighbor to the man who fell into the hands of robbers?”
37 The expert in the law replied, “The one who had mercy on him.”
Jesus told him, “Go and do likewise.”](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:7e6gdj33irtt6i7vc6hozfah/bafkreighn5sh4h5qhpcb7pzh6icaxp4lybocxu5fduygkiyz4dl5cjd64i)
Prasad Jallepalli, MD, PhD@prasad.bsky.social · 8mo agolaying a trap for the Good Samaritan is the wrong lesson to learn
Almost done with my next lecture, so going back now to work on some new memes
❤️🩹 CHI Superhero Mohammedzayn on Hyperinsulinism: “My state of mind changes, like the waves in the ocean; the higher waves will always come crashing down. My brain is a victim to my bloods, headaches, weariness, turning on and off the bulb of intelligence and wonder.”
My quote of the day My dream is of a place and a time where America will once again be seen as the last best hope of earth. Abraham Lincoln
Studies in cells and mice reveal that the human GLP1R A316T variant exhibits characteristics of constitutive activation but dampened GLP-1RA responses www.science.org/doi/10.1126/...
In vivo functional profiling and structural characterization of the human GLP1R A316T variant
The GLP1R A316T missense variant displays improved glucose tolerance but impaired pharmacological incretin responses in vivo.
science.org
Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro www.wsj.com/health/pharm...
Joel Habener, Whose Research Helped Develop Weight-Loss Drugs, Dies at 88
Habener led research that discovered the GLP-1 hormone, a key ingredient in Ozempic and Mounjaro.
wsj.com
My quote of the day If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith. Ehsan Sehgal
One of my fav tik tok accounts was chandler and his grandma.
📣Understanding Hyperinsulinism and sharing our links is valuable because it leads to: ✅ Better support and understanding for individuals with HI ✅ Early Diagnosis and Prompt Intervention ✅New families are reached ✅New connections are made https://linktr.ee/chcharityuk
Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs. 🧵
There is LOT more where that came from. If you like THEY KNEW, please spread the word about the $2.99 sale! I don't make hardly any money off this. I only want people to read the book and know the truth about our country, our past, and our future. Thank you!
This is must-listen for all of us who are scientists - and all who question science
Dan Levenstein@dlevenstein.bsky.social · last yr.Great interview with Hasok Chang on 'Epistemic Iteration': The idea that we don't often start scientific inquiries from a solid foundation. We knowingly start from an imperfect position, and use the outcomes to refine and correct the original starting point. open.spotify.com/episode/6tbT...
I once asked a scientist whom I respect enormously her advice for a successful career and life in science. Her advice: Leave every place better than you found it. It surprises me that many people would try hard to do the compete opposite … and we would elect them to run the country.
Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.
‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical Journal
The New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter.
nytimes.com
