Mohanad Al-Obaidi
@mycosis.bsky.social
Medical mycology and transplant ID
This is a super nerdy plug, but I really have enjoyed working for Highlights, and a couple of the magazine covers shown were ones I wrote for! www.cbsnews.com/video/highli...
Highlights magazine celebrates 80 years
For decades, children have sent Highlights magazine their drawings, poems, questions and concerns. Now Highlights is turning 80. We took a look back at the beloved magazine's history.
cbsnews.com
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
nyti.ms
New #IDSAGuidelines! IDSA has released an evidence-based guideline update on antiviral treatment for mild to moderate COVID-19 in infants, children, and adolescents: https://bit.ly/2ScnyDZ
Effectiveness of RSV vaccines in SOT population using Epic Cosmos EHR data. #IDSky #TxID pubmed.ncbi.nlm.nih.gov/42250880/
Effectiveness of Respiratory Syncytial Virus Vaccination in Solid Organ Transplant Recipients in the United States - PubMed
Respiratory syncytial virus (RSV) is associated with high morbidity in solid organ transplant recipients (SOTRs) and the effectiveness of the RSV vaccine in this population is unknown. We sought to as...
pubmed.ncbi.nlm.nih.gov
Leishmaniases comprise clinically distinct diseases caused by the protozoan parasite leishmania, transmitted through the bite of infected sand flies. A new review summarizes current approaches and recent advances in the diagnosis and treatment of leishmaniasis. Full review: https://nej.md/4nPCWn6
Studying hundreds of patients with severe coccidioidomycosis, we found two patterns of immune dysregulation. Th2 skewing affects about 25% of DCM (mostly males!), while T-cell exhaustion (like cancer) arises early during infection in those with DCM and causes reduced responses. Both are treatable!
JCI insight@insight.jci.org · 5mo agoTwo Research articles in this issue explore immune phenotypes from individuals with coccidioidomycosis including those with severe, life-threatening disease: doi.org/10.1172/jci.... & doi.org/10.1172/jci....
Two Research articles in this issue explore immune phenotypes from individuals with coccidioidomycosis including those with severe, life-threatening disease: doi.org/10.1172/jci.... & doi.org/10.1172/jci....
pubmed.ncbi.nlm.nih.gov/42171361/
Emerging evidence for anti-PD-1 and IFN-γ as adjunctive immunotherapy in invasive mold infections - PubMed
This study provides preliminary evidence supporting the clinical relevance of host-directed immunotherapy as an adjunct to antifungal treatment in severe invasive mold diseases (IMDs), which remain as...
pubmed.ncbi.nlm.nih.gov
Plasma Cell-Free DNA PCR has ~50% sensitivity with lower sensitivities for localized pulmonary disease compared to higher sensitivities in disseminated disease and immunosuppressed hosts, reflecting previous observation with antigenic tests. #IDSky #medmyco academic.oup.com/cid/advance-...
Accuracy of Plasma Cell-Free DNA PCR for Diagnosis of Coccidioidomycosis
Diagnosis of coccidioidomycosis can be challenging with conventional diagnostics and may require collection of an invasive specimen. This study showed that
academic.oup.com
Before treatment was available, HIV was lethal enough to reduce the frequency of “disease-susceptible” alleles for immune proteins known as HLA-Bs in KwaZulu-Natal, South Africa. Antiretroviral therapy radically slowed HLA-B frequency change. In PNAS: https://ow.ly/a8f150YV5Fr
#TxID #IDSky onlinelibrary.wiley.com/doi/abs/10.1...
Screening and Reactivation of Chagas Disease Among Solid Organ Transplant Candidates and Recipients: A 10‐Year Single Center Experience in Florida
This retrospective cohort from a US transplant center found a high incidence of Chagas disease reactivation with overall favorable 2-year outcomes. Most reactivations occurred early post-transplant, ...
onlinelibrary.wiley.com
A single mushroom can release 3 BLLION spores a day at a rate of 30,000 PER SECOND. A single giant puffball can produce 7 TRILLION spores in its lifetime. Each year, fungi collectively produce 50 million TONS of them, enough to coat every square mm of Earth with 1,000 spores. Let's talk about it.
One-month treatment for latent tuberculosis. Why aren't we using it? (Hint: We should.) voices.nejm.org/doi/full/10....
One-Month Treatment for Latent Tuberculosis
Why aren’t we using it?
voices.nejm.org
🚀 Artemis II is safely in orbit! 🚀 A daring 10-day voyage will take four astronauts on a loop around the moon and set the stage for future forays to the lunar surface
NASA’s Artemis II launches on first crewed moon mission of the 21st century
A daring 10-day voyage will take four astronauts on a loop around the moon and set the stage for future forays to the lunar surface
scientificamerican.com
Incidence and outcomes of influenza-associated pulmonary aspergillosis and the role of antifungal prophylaxis: a structured literature review Work informing aims of @galactic-europe.bsky.social Comgrats to all involved. rdcu.be/fazXN
Incidence and outcomes of influenza-associated pulmonary aspergillosis and the role of antifungal prophylaxis: a structured literature review
rdcu.be
Weird case of a liver transplant recipient in Idaho dying of Japanese encephalitis virus, which does not circulate in the US. The donor was a trauma patient who had received blood transfusions prior to death, and been exposed to seaports in southern California, but had not traveled to Asia #IDSky
Probable Japanese Encephalitis Virus Transmission through Organ Transplantation | NEJM
Infection with Japanese encephalitis virus, a mosquito-borne flavivirus, was identified in a patient who received a liver transplant from a donor who resided in California.
nejm.org
Phase 2 data on omadacycline use in treatment of pulmonary M abscessus #IDSky
Omadacycline Monotherapy in Nontuberculous Mycobacterial Pulmonary Disease Caused by Mycobacterium abscessus: Results From a Phase 2, Double-blind, Randomized, Placebo-controlled Study
In this randomized, controlled trial of patients with nontuberculous mycobacterial pulmonary disease caused by Mycobacterium abscessus, symptom and microbi
academic.oup.com
I'm craving sushi: let's talk about who *invented it*. Our story starts in the Mekong River valley: Laos, Cambodia, Thailand. Locals realize they can preserve river fish in barrels with layers of salt & rice for YEARS, a precaution against drought, famine.
A 🕵️ was in this case investigation: While performing investigation of water system in pt w/ Legionella, infection control found an unregistered water flosser. They ran sterile water through flosser and Legionella grew + matched infection strain wwwnc.cdc.gov/eid/article/... #IDSky
Case of <em>Legionella pneumophila</em> Serogroup 1 Infection Linked to Water Flosser, France
<em>L. pneumophila</em> Infection Linked to Water Flosser
wwwnc.cdc.gov
Framework for pivoting to #DOOR in #mycology! Very excited about this publication from @msgerc.bsky.social #IDSky #MedSky academic.oup.com/ofid/article...
Development Framework of Desirability of Outcome Ranking Endpoints for Use in Clinical Trials of Invasive Fungal Diseases
Utilizing a modified Delphi process, 53 fungal experts from 16 countries developed consensus endpoints for clinical trials targeting invasive candidiasis,
academic.oup.com
New @cidjournal.bsky.social article on febrile neutropenia from @uwidfellowship.bsky.social: “Of 503 patients with ≥1 blood culture collected after FN day 3, 19 (4%) had a new BSI after FN day 3” Authors suggest low utility of repeat BCx after day 3 #IDSky academic.oup.com/cid/advance-...
Diagnostic Yield of Repeat Blood Cultures and Risk Factors for Bloodstream Infection in Persistent Febrile Neutropenia
New bloodstream infections after day 3 of febrile neutropenia (FN) were uncommon in patients with cancer and hematopoietic cell transplant (HCT) recipients
academic.oup.com
Beyond Fumigatus: a molecular portrait of clinical Aspergillus diversity, pathogenicity, and antifungal resistance. #MedMyc #infectiousdisease #IDSky
Beyond Fumigatus: a molecular portrait of clinical Aspergillus diversity, pathogenicity, and antifungal resistance | Antimicrobial Agents and Chemotherapy
Aspergillus species are a major cause of fungal-related morbidity and mortality worldwide, particularly among individuals with chronic obstructive pulmonary disease (1), patients in intensive care uni...
journals.asm.org
academic.oup.com/ofid/advance...
Compassionate Use of Olorofim for Invasive Mold Infections: A Nationwide Observational Study in France
This first report of olorofim use in real-world clinical practice highlights the promising efficacy and good tolerability of olorofim in patients with inva
academic.oup.com
Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis #IDSky
Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis
Invasive pulmonary aspergillosis (IPA), once limited to immunocompromised patients, is now a severe complication in critically ill ICU patients without classic risk factors.
academic.oup.com
#idboardreview 60 M idiopathic pulmonary fibrosis s/p lung transplant 2wks ago( on antithymocyte globulin, tacro, azathioprine, pred) now w/ pleuritic chest pain, dyspnea. +emypema s/p drainage: pinpoint colonies. diagnosis? #medEd #idmedEd #idsky
Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine. If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
