@myosinactncrazy.bsky.social
#1 molecular motor, cytoskeletal motors, cytoskeletal filaments, filament dynamics, cell migration, mechanobiology, morphogenesis
Adaptive motility enables neutrophils to rapidly navigate confined capillaries | Science Immunology www.science.org/doi/10.1126/...
Adaptive motility enables neutrophils to rapidly navigate confined capillaries
Neutrophils maintain migration speed in confined capillaries through adaptive actomyosin remodeling.
science.org
Check out our preprint on the structural mechanisms of how LEM2 and ESCRTs seal the nuclear envelope. Awesome collaboration with @karenpalacior.bsky.social who brought my structures to life 💃🔬❄️🌀 @hummerlab.bsky.social www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6... Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction
www.biorxiv.org/content/10.6... Dynamic microtubules drive yolk-cytoplasm segregation in the syncytial Drosophila embryo
www.nature.com/articles/s41... The membrane-to-cortex distance regulates mDia1 activity to control cortical mechanics
The membrane-to-cortex distance regulates mDia1 activity to control cortical mechanics - Nature Communications
The surface of mammalian cells is a multi-layered composite structure. The authors combine advanced biophysical methods with cryo-electron tomography to identify the gap between the membrane and the a...
nature.com
pubs.acs.org/ancac3/artic... Cryo-Electron Tomography Reveals Nanoscale Thick Filament Disorganization in MYH7 P710R Hypertrophic Cardiomyopathy Cardiomyocytes
The actomyosin cortex controls t-tubule remodeling in skeletal muscle www.science.org/doi/10.1126/...
The actomyosin cortex controls t-tubule remodeling in skeletal muscle
A network of plasma membrane invaginations called t-tubules plays an essential role in controlling calcium release from the endoplasmic reticulum at the triads during muscle contraction. Although the ...
science.org
We are excited to invite you to the second webinar in our cell migration series. In this webinar, we focus on new models for studying cell migration with talks from @ankita13jha.bsky.social, @raphclement.bsky.social & @katrinavelle.bsky.social. More info⤵️: focalplane.biologists.com/2026/09/03/f...
www.biorxiv.org/content/10.6... Ex vivo glioblastoma migration phenotypes define clinical recurrence and tumor heterogeneity
www.biorxiv.org/content/10.6... Melanophilin, a Myosin Va Adapter Protein, Biases Track Selection of Myosin Va-and Kinesin-1-Transported Liposomes at Actin-Microtubule Intersections In Vitro
www.biorxiv.org/content/10.6... Nuclear Myosin VI stabilises Ku-associated DNA ends during non-homologous end joining
www.biorxiv.org/content/10.6... The nuclear actin cytoskeleton supports DNA double-strand break repair via VCP-mediated extraction of the KU70/80 complex from damaged chromatin
www.biorxiv.org/content/10.6... The filopodial scaffold polyphosphate dictates cell adhesion-versus-invasion decisions
beautiful work!
Thibaut Brunet@thibautbrunet.bsky.social · 3d ago🚨 New preprint alert! 🚨 Choanoflagellates reorganize their global cytoskeletal architecture within seconds to explore confined microspaces. This is the main PhD work of the amazing @maitefreired.bsky.social www.biorxiv.org/content/10.6... A tread 🧵⬇️
Great speakers, great science, great location = great meeting! EMBO workshop Forces across scale April 27-30, 2027 in Porto. meetings.embo.org/event/27-for...
Forces across scales
This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…
meetings.embo.org
pubs-acs-org.ezp3.lib.umn.edu/jafcau/artic... Discovery of Novel Cyanoacrylates as Potential Myosin I Inhibitors with Remarkable Activity against Fusarium Species
Happy to share our new study @ijmonod.bsky.social on how surface curvature shapes multicellular organization and function. How curvature controls tissue chirality, patterns distinct architectures, and influences myogenic differentiation? www.biorxiv.org/content/10.6...
Pre-Print Alert! 🚨 Combining AFM with spatial transcriptomics to identify targets for cancer mechanics research! A huge effort from our fantastic PhD student @lindithium.bsky.social and our amazing collaborators at @uniklinik_hd, @uniklinikkoeln.bsky.social, and @embl.org!
Linda Decker@lindithium.bsky.social · 4d agoExcited to present mechanoMaST, our workflow that spatially maps AFM-based mechancis to Spatial Transcriptomics as a preprint and in a selected talk today at the @cancergrand.bsky.social Spatial Biology Conference! BioRxiv: doi.org/10.64898/202... @diz-lab.bsky.social @biorxivpreprint.bsky.social
www.molbiolcell.org/doi/10.1091/...
A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1 | Molecular Biology of the Cel...
Animal tissues have diverse architectures and cell behaviors across the epithelial-mesenchymal spectrum. Cell adhesion mediated by classical cadherins is foundational. Cadherins nucleate complexes of ...
molbiolcell.org
CCT8 associates with the MYO10 motor domain and regulates filopodia and breast cancer cell invasion journals.biologists.com/jcs/article/...
Really cool! Smaller than GFP and reversibly binding last-generation rhodamine dyes. De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles www.cell.com/cell/fulltex... Congrats @bohuang.bsky.social @rhodamine110.bsky.social @mullinslab.bsky.social et al
📣Paris Cytoskeleton Day - Registrations are open! 📅 November, 24th 📍Institut Jacques Monod Abstract submission closes on 2 November Registration closes on 16 November 🔗 pcd2026.sciencesconf.org
Myosin researcher Dr. James Sellers is headlining the 2026 Triangle Cytoskeleton Meeting. Hear how nonmuscle myosin 2 paralogs handle force, catch-bonds, and actin dynamics in his talk: "Nonmuscle myosin 2: Short, slow and stubborn." Registration is still open: trianglecytoskeleton.com
www.biorxiv.org/content/10.6... Epidermal cells sculpt sensory nerve endings through actomyosin contractility
www.biorxiv.org/content/10.6... Optogenetic control of actin crosslinker length reveals a mechanical basis for cortical symmetry breaking
Captivated by Kinesin - by Ron Vale published in Cytoskeleton onlinelibrary.wiley.com/doi/10.1002/... " In this essay, I reflect on how I first encountered kinesin and how it taught me to watch cells and proteins directly, letting observation reveal nature's workings."
Mechanistic basis for calmodulin‑dependent allosteric activation of the neuropathy-associated formin INF2: Cell Reports www.cell.com/cell-reports...
Mechanistic basis for calmodulin‑dependent allosteric activation of the neuropathy-associated formin INF2
Zhang et al. demonstrate that calcium-bound calmodulin directly binds to the neuropathy-associated formin INF2, triggering an allosteric rearrangement that relieves autoinhibition and drives actin fil...
cell.com
Microscale matrix defects suppress tension-dependent protrusions and stall collective cell migration: Cell Reports www.cell.com/cell-reports...
Microscale matrix defects suppress tension-dependent protrusions and stall collective cell migration
Zmuda et al. show that microscale defects on soft collagen-IV stall epithelial migration via filopodial sensing and intercellular communication of cytoskeletal disruption. Stiffer matrices, switching ...
cell.com
Architecture of distal tips of motile cilia is shaped by the pseudoenzyme Jhc1 in non-mammalian vertebrates: Cell Reports www.cell.com/cell-reports...
Architecture of distal tips of motile cilia is shaped by the pseudoenzyme Jhc1 in non-mammalian vertebrates
Hong et al. identify Jhc1, a ciliary protein localizing at the EDT of MCC cilia, conserved only among non-mammalian vertebrates. They provide insights into how evolution shapes the diversity of the ti...
cell.com
