Broad Institute
@broadinstitute.org
A multidisciplinary community of researchers with the mission to better understand the roots of disease and narrow the gap between new biological insights and impact for patients. Broadinstitute.org
Congratulations to Broadies Yasha Ektefaie, @rahulg603.bsky.social, and Mohamed El-Brolosy on being named 2026 #STATWunderkinds!
Meet the 2026 STAT Wunderkinds
This year, as in past years, we've found inspiring stories and innovative research. All are blazing new trails as they attempt to answer some of the
statnews.com
Congratulations to @yerinchen.bsky.social and @ctspeng.bsky.social for receiving the NIH Director’s New Innovator Award, and to @jtneal.bsky.social for his NIH Director’s Transformative Research Award!
Three Broad researchers honored by NIH’s High-Risk, High-Reward Program
Erin Chen and Sam Peng receive the NIH Director's New Innovator Award for innovative, early-career investigators; JT Neal receives the NIH Director's Transformative Research Award for bold, groundbrea...
broad.io
Join us October 29 from 6-8 pm for an evening of science after hours! Discovery After Dark features interactive exhibits, a simulation with Operation Outbreak, and the chance to connect with Broad scientists. Advanced registration required. Register: broadinstitute.swoogo.com/dad2026/1300...
We’re delighted to announce that the HCA Organizing Committee (OC) has selected Muzz Haniffa and Alexandra-Chloé Villani to be the next Co-Chairs of the HCA OC, and Shyam Prabhakar and Holger Heyn as co Vice-Chairs. #HumanCellAtlas @mhaniffa.bsky.social @hoheyn.bsky.social
Survey of mitochondria proteomes across eukaryotes explores organelle’s role, suggests it originated late in eukaryotic evolution, and highlights possible drug targets for tropical diseases.
Catalog of mitochondria across life’s family tree unearths new roles for the cell’s powerhouse
Survey of mitochondrial proteomes across eukaryotic taxa reveals clues to the organelle’s origins and functions, and suggests possible new opportunities for treating parasitic infections.
broad.io
New method allows scientists to connect disease-linked regulatory genetic variants to the genes they control. These variants are more likely to influence disease risk if they alter chromatin accessibility that then changes gene expression.
Atlas of immune cells explains how genetic variants cause disease
A new method reveals which genetic variants are most important in disease and how cells “buffer” the expression of genes critical for health.
broad.io
Our single-nucleus immune multiome atlas is now out in @nature.com! 🧬 10M PBMCs from 1,108 @finngen.bsky.social donors recruited by Finnish Blood Service, profiled at @broadinstitute.org with chromatin accessibility and gene expression in the same nuclei, to trace how disease variants act 🧵👇
The @novo-nordisk.bsky.social is renewing its commitment to Broad with a $53M investment. With Danish scientists, the Center will leverage massive-scale data, AI, and cellular models to decode the genetic drivers of type 2 diabetes and obesity. broad.io/NNFCRenewal
To aid in virus outbreak responses, Broad researchers from @sabetilab.bsky.social and @fathom.info created Delphy.bio, a free web tool to reconstruct how a virus is spreading and changing using viral genomic data, reducing a months-long task into one that takes hours.
Software rapidly tracks viral variants with high accuracy
A new web-based program called Delphy assembles viral family trees at unprecedented speed to aid outbreak responses.
broadinstitute.org
New method lets scientists watch gene activity unfold in living cells over time, by engineering cells to package their own RNA into virus-like particles they release, ready for researchers to collect and sequence.
New method allows scientists to follow gene activity over time in the same cells
In the new method, cells package and export their RNA, enabling researchers to sequence and analyze the RNA without killing the cells.
broad.io
New preprint from our collaboration with Caroline Uhler and @broadinstitute.org on TissueFormer, a new tool for predicting spatial gene expression from histology images at cellular resolution www.biorxiv.org/content/10.6...
Multi-Modal Foundation Model with Whole-Slide Attention Enables Transferrable Digital Pathology at Single-Cell Resolution
Paired histopathology and spatial transcriptomics data are advancing our understanding of tissue biology and disease, but modeling both modalities at single-cell resolution while mapping local and dis...
biorxiv.org
A week-overdue 🧵on the newest paper from the Cimini lab- do you ever do spatial transcriptomics? If you do, and you want free extra phenotypic info, step in to learn more about "Evaluating integrative strategies for incorporating phenotypic features in spatial transcriptomics". 🧪 (1/x)
Evaluating integrative strategies for incorporating phenotypic features in spatial transcriptomics
Spatial transcriptomics (ST) encompass technologies that measure gene expression in tissue samples without disrupting their organisation, unlike other single-cell techniques. In imaging-based ST spec...
onlinelibrary.wiley.com
Nominations are now open for the 2027 Merkin Prize in Biomedical Technology! 🏆 This international $400,000 prize recognizes pathbreaking technologies that have improved human health through treatment, diagnosis, or prevention of disease. Learn more: merkinprize.org
Mechanistic machine learning for prediction of prime editing outcomes - @broadinstitute.org @hhmi-science.bsky.social www.nature.com/articles/s41...
Mechanistic machine learning for prediction of prime editing outcomes - Nature Biotechnology
OptiPrime incorporates prime-editing biochemistry to predict prime-editing outcomes.
nature.com
OptiPrime, a new AI model from David Liu's lab, helps scientists choose the best pegRNAs to make a desired edit, avoiding slow and costly steps in the lab and streamlining development of gene-editing medicines for rare diseases.
AI model streamlines prime editing
The tool, called OptiPrime, helps researchers more easily determine the best guide RNAs for efficient prime editing, avoiding costly, time-consuming steps in the lab.
broad.io
The Cancer Dependency Map now includes data from dozens of 3D cancer models across 10 cancer types, revealing new dependencies and offering a more comprehensive resource for cancer research.
Cancer Dependency Map now includes next-generation 3D cancer models
Broad scientists expand the DepMap by adding cancer organoids and demonstrate the models’ potential to fuel new discoveries.
broad.io
This Thursday, August 6, at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with @jbuenrostro.bsky.social: Uncovering Adversity's "Molecular Scars." Register: broadinstitute.swoogo.com/bds2026
Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells - @broadinstitute.org @hhmi-science.bsky.social www.nature.com/articles/s41...
Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells - Nature Biotechnology
Directed evolution of proteases induces targeted, multipathway lytic cell death in cancer cells.
nature.com
New work with Ben Medoff's lab, online now! ADAMTS14 regulates YAP-driven fibroblast activation in IPF. We define an ADAMTS14–collagen V–focal adhesion pathway that contributes to $fibrosis, highlighting ADAMTS14 as a potential therapeutic target. doi.org/10.1093/ajrc...
ADAMTS14 is a Novel Modulator of Fibroblast Mechanoactivation in Pulmonary Fibrosis
AbstractRationale. Yes-associated protein (YAP)-mediated fibroblast mechanoactivation is an important driver of fibrosis in idiopathic pulmonary fibrosis (
doi.org
We're thrilled to announce the Center for Therapeutic Genetics (CTG) — a new collaboration between Broad, Boston Children’s Hospital, and Jackson Laboratory to develop genetic medicines for rare and ultra-rare diseases. (1/3)
Broad Institute, Boston Children’s Hospital, and The Jackson Laboratory launch the Center for Therapeutic Genetics, a non-profit effort to develop genetic medicines for rare and ultra-rare diseases
The new collaboration aims to develop precision medicines, including base and prime editing, to treat patients with rare diseases, using infrastructure and repeatable practices the center will share w...
broad.io
Thank you Broad Institute of MIT and Harvard for this profile. The last 2 years have been an extraordinary moment of creativity and inspiration. If you’re interested in joining us, PM me! We’re building new methods, models and ML tools - we’re recruiting at all levels!
Broad Institute@broadinstitute.org · 3mo agoShaped by a tumultuous childhood, Broad researcher and epigenomic tool-maker @jbuenrostro.bsky.social pivots to studying the biology of stress and adversity and finding new ways to boost resilience.
Shaped by a tumultuous childhood, Broad researcher and epigenomic tool-maker @jbuenrostro.bsky.social pivots to studying the biology of stress and adversity and finding new ways to boost resilience.
A bioengineer shifts his career to explore how life experiences change the body
Shaped by a tumultuous childhood, Jason Buenrostro pivots from technology development to studying the biology of stress and adversity and finding new ways to boost resilience.
broad.io
Join us on Thursday, August 6, at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with @jbuenrostro.bsky.social: Uncovering Adversity's "Molecular Scars." Register: broadinstitute.swoogo.com/bds2026
We're thrilled to announce that, along with @broadinstitute.org, @bostonchildrens.bsky.social, RARE Hope and partners, JAX was selected for ARPA-H THRIVE Award to advance gene editing platform for pediatric epilepsies and rare CNS diseases. 🧪🧬🧠
The Jackson Laboratory, with the Broad Institute and partners, selected for ARPA-H THRIVE Award to advance gene editing platform for pediatric epilepsies and rare CNS diseases
Pediatric Epilepsies & Rare CNS Gene Editing Platform (PERC) accelerates the development of precision genetic medicines for severe childhood neurologic disease.
jax.org
We're thrilled to announce that a Broad-led consortium of 12 organizations has been selected to receive funding from @arpa-h.bsky.social under its THRIVE program to launch the Pediatric Epilepsies and Rare CNS (PERC) Gene Editing Platform. broad.io/ARPA-H (1/5)
Broad-led consortium receives ARPA-H award to advance gene editing for rare pediatric epilepsy
Twelve organizations spanning gene editing science, clinical medicine, manufacturing, regulatory strategy, and patient advocacy aim to deliver first-in-human trial within three years. div.hero-section...
broad.io
So excited to see this published! This method was a long time in the making and is now being widely used to balance scale with depth, especially for participants where unbiased sequencing approaches are so much more useful than arrays
Broad Institute@broadinstitute.org · 3mo agoBroad scientists developed the Blended Genome Exome (BGE) sequencing method, which delivers high-quality, unbiased data at a lower cost than existing gold-standard methods and makes large-scale genetic studies more feasible. @genetisaur.bsky.social
Broad scientists developed the Blended Genome Exome (BGE) sequencing method, which delivers high-quality, unbiased data at a lower cost than existing gold-standard methods and makes large-scale genetic studies more feasible. @genetisaur.bsky.social
Low-cost genome sequencing approach is powering genetics research on mental illness and many other studies
The Blended Genome Exome approach delivers high-quality, unbiased genetic data at a quarter of the cost of the leading sequencing method.
broad.io
New research in Nature Methods from Project Ex Vivo shows AI models learn more from diverse cell states than from scaled datasets alone, a finding that could reshape how therapies are matched to patients. msft.it/6013vgE8l
The 2026 Richard N. Merkin Prize in Biomedical Technology honors Graeme Clark, Erwin Hochmair, Ingeborg Hochmair, Michael Merzenich, and Blake Wilson for developing the modern cochlear implant — a device used by more than 1 million people worldwide.
2026 Merkin Prize in Biomedical Technology awarded to pioneers of the modern cochlear implant
The $400,000 prize honors five researchers who developed the first medical device to generate a human sense through a direct neural interface, a groundbreaking tool used by more than one million peopl...
broad.io
In three new studies, the David Liu lab has optimized key prime editing components (guide pegRNA motifs, reverse transcriptase stability, and delivery via lipid nanoparticles), addressing key bottlenecks that previously impeded its use in animals and human patients.
Scientists improve nearly every aspect of prime editing, moving it closer to treating more genetic diseases
The advances in editing efficiency and delivery are important steps toward in vivo therapeutic prime editing.
broadinstitute.org