Neuroimmune connections

New perspectives, insights and therapy applications can arise from exploring the connections between the immune and nervous systems.

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Nature Immunology - Keratinocyte–fibroblast circuits in photosensitive autoimmunity

Spatial genomics and single-cell profiling reveal the immune architecture of cutaneous lupus erythematosus, a photosensitive autoimmune skin disease. Wang et...

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Purine salvage pathway protects CD8+ T cells from metabolic stress - Nature Immunology

Tajima et al. show that a transient or continuous high-fat diet induces metabolic changes in CD8+ T cells that lead to increased vulnerability to ferroptosis and reduced antitumor responses.

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Multimerizing transcription factors FOXP3 and AIRE as chromatin architectural regulators - Nature Immunology

Hur and colleagues review recent developments to provide insights into the molecular mechanisms and regulatory functions of the transcriptional regulators FOXP3 and AIRE.

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A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation

Nature Immunology - Xie et al. identify a distinct subset of CD4+ helper T cells expressing EOMES and granzyme K in both mice and human models of colitis.

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Blood vessel-resident macrophages safeguard blood and vessel integrity in zebrafish

Nature Immunology - Robin and colleagues describe a population of blood vessel-resident macrophages that function within the vasculature to maintain vascular and blood homeostasis in zebrafish and...

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TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells

Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....

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TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells - Nature Immunology

Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and adaptive NK cell responses to viral in...

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Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells

Nature Immunology - Klein and colleagues show that the lysosomal cysteine protease cathepsin L shapes the diversity and optimizes the fitness of clones that enter the CD4+ T cell repertoire.

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Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch

Nature Immunology - Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor...

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PD-1 receptor deficiency enhances CD30+ Treg cell function in melanoma

Nature Immunology - Here the authors show that PD-1 controls coinhibitory receptor expression by Treg cells. The absence of PD-1 expression could induce CD30 expression, thereby enhancing Treg...

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A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma

Nature Immunology - Here, the authors use single-cell spatial transcriptomics to profile the airway wall landscape in health and during asthma. Discrete proinflammatory ecosystems containing...

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Cholinergic regulation of thymocyte negative selection

Nature Immunology - Acetylcholine–α9 nAChR signaling regulates thymic negative selection.

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Bat organoids reveal antiviral responses at epithelial surfaces

Nature Immunology - Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated...

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GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence - Nature Immunology

Belz and colleagues show that GFI1, a transcriptional repressor that recruits histone-modifying enzymes, is necessary for the generation and maintenance of stem cell memory CD8+ T cells.

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Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease

Nature Immunology - FitzPatrick et al. use single-cell RNA and spatial transcriptomics to dissect the immune microenvironments within the small bowel mucosa in celiac disease.

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Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice

Nature Immunology - Iwasaki and colleagues show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with an mRNA vaccine encoding...

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Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer

Nature Immunology - Metabolites in the tumor microenvironment, including adenosine, have been shown to suppress anti-tumor immune responses. Here, the authors show that T cell expression of...

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