The therapeutic approach to cardiovascular–kidney–metabolic syndrome

Nature Reviews Nephrology, Published online: 05 August 2026; doi:10.1038/s41581-026-01109-6Here the authors discuss the therapeutic approach to cardiovascular–kidney–metabolic syndrome, including screening across the lifespan, lifestyle interventions and guideline-directed medical therapies. They also discuss cardiovascular–kidney risk assessment and the need for multidisciplinary approaches to address fragmented care delivery and therapeutic inertia.

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Adressing the high burden of kidney disease: lessons from Taiwan

Nature Reviews Nephrology, Published online: 30 July 2026; doi:10.1038/s41581-026-01112-xTaiwan carries one of the world’s heaviest kidney disease burdens globally; however, its single-payer universal health-care system has enabled policy-driven transformation of kidney care through population-level screening, multidisciplinary pay-for-performance programmes, data-driven surveillance and digital innovation. These strategies have reduced disease incidence and improved outcomes, and provide a replicable model for health systems elsewhere.

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Nephrology care for incarcerated people: a call to action

Nature Reviews Nephrology, Published online: 28 July 2026; doi:10.1038/s41581-026-01108-7The carceral system has the impossible task of providing appropriate care for a vulnerable population while limiting taxpayer spending. Although many risk factors for incarceration also increase the risk of chronic kidney disease (CKD), specific CKD screening requirements or treatment accountability are lacking, which compromises patient care.

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Insights from integrative spatial transcriptomics in sepsis-associated acute kidney injury

Nature Reviews Nephrology, Published online: 28 July 2026; doi:10.1038/s41581-026-01107-8The complexity of the host responses that underlie sepsis-associated acute kidney injury (SA-AKI) complicates patient management and contributes to its high mortality. Here, the authors examine insights into the pathophysiology of SA-AKI gained from the integration of high-resolution spatial transcriptomics with other multi-omics approaches, and consider how these technologies might enable targeted therapeutic interventions.

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Epigenetic regulation of kidney development

Nature Reviews Nephrology, Published online: 28 July 2026; doi:10.1038/s41581-026-01105-wThis Review describes current understanding of the epigenetic regulation of kidney development. It describes the epigenetic drivers of cell fate decisions made by nephron progenitor cells, the chromatin landscape of accessible regulatory elements that orchestrate these decisions, and the functional consequences for congenital kidney diseases and the programming of adult kidney disease.

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WNT organizers control nephron patterning in organoids

Nature Reviews Nephrology, Published online: 27 July 2026; doi:10.1038/s41581-026-01113-wWNT organizers control nephron patterning in organoids

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The first-in-human combined bladder and kidney transplant

Nature Reviews Nephrology, Published online: 27 July 2026; doi:10.1038/s41581-026-01114-9The first-in-human combined bladder and kidney transplant

dlvr.it

Adressing the high burden of kidney disease: lessons from Taiwan

Nature Reviews Nephrology, Published online: 30 July 2026; doi:10.1038/s41581-026-01112-xTaiwan carries one of the world’s heaviest kidney disease burdens globally; however, its single-payer universal health-care system has enabled policy-driven transformation of kidney care through population-level screening, multidisciplinary pay-for-performance programmes, data-driven surveillance and digital innovation. These strategies have reduced disease incidence and improved outcomes, and provide a replicable model for health systems elsewhere.

dlvr.it

Beyond paediatric nephrology: gaps in care for young adults

Nature Reviews Nephrology, Published online: 24 July 2026; doi:10.1038/s41581-026-01110-zThe prevalence of kidney disease is increasing in children and young adults, who face a lifetime of chronic disease with considerable morbidity and mortality. However, a critical shortage in the paediatric nephrology workforce and deficiencies in paediatric-to-adult transition care mean that we fail to meet the needs of this vulnerable population. Paediatric and adult nephrologists need to take collaborative action to address this crisis.

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Disease modification in lupus nephritis: towards a pathophysiology-based treatment paradigm

Nature Reviews Nephrology, Published online: 23 July 2026; doi:10.1038/s41581-026-01103-yThis Review provides an overview of the pathophysiology of systemic lupus erythematosus as well as drugs that have been developed to target these pathophysiological processes. The authors also synthesize a translational approach aimed at enabling disease modification in lupus nephritis through the integration of glucocorticoids and conventional antiproliferative agents with immunomodulatory drugs.

dlvr.it

Nephrology care for incarcerated people: a call to action

Nature Reviews Nephrology, Published online: 28 July 2026; doi:10.1038/s41581-026-01108-7The carceral system has the impossible task of providing appropriate care for a vulnerable population while limiting taxpayer spending. Although many risk factors for incarceration also increase the risk of chronic kidney disease (CKD), specific CKD screening requirements or treatment accountability are lacking, which compromises patient care.

dlvr.it

Insights from integrative spatial transcriptomics in sepsis-associated acute kidney injury

Nature Reviews Nephrology, Published online: 28 July 2026; doi:10.1038/s41581-026-01107-8The complexity of the host responses that underlie sepsis-associated acute kidney injury (SA-AKI) complicates patient management and contributes to its high mortality. Here, the authors examine insights into the pathophysiology of SA-AKI gained from the integration of high-resolution spatial transcriptomics with other multi-omics approaches, and consider how these technologies might enable targeted therapeutic interventions.

dlvr.it

Epigenetic regulation of kidney development

Nature Reviews Nephrology, Published online: 28 July 2026; doi:10.1038/s41581-026-01105-wThis Review describes current understanding of the epigenetic regulation of kidney development. It describes the epigenetic drivers of cell fate decisions made by nephron progenitor cells, the chromatin landscape of accessible regulatory elements that orchestrate these decisions, and the functional consequences for congenital kidney diseases and the programming of adult kidney disease.

dlvr.it

WNT organizers control nephron patterning in organoids

Nature Reviews Nephrology, Published online: 27 July 2026; doi:10.1038/s41581-026-01113-wWNT organizers control nephron patterning in organoids

dlvr.it

The first-in-human combined bladder and kidney transplant

Nature Reviews Nephrology, Published online: 27 July 2026; doi:10.1038/s41581-026-01114-9The first-in-human combined bladder and kidney transplant

dlvr.it

Beyond paediatric nephrology: gaps in care for young adults

Nature Reviews Nephrology, Published online: 24 July 2026; doi:10.1038/s41581-026-01110-zThe prevalence of kidney disease is increasing in children and young adults, who face a lifetime of chronic disease with considerable morbidity and mortality. However, a critical shortage in the paediatric nephrology workforce and deficiencies in paediatric-to-adult transition care mean that we fail to meet the needs of this vulnerable population. Paediatric and adult nephrologists need to take collaborative action to address this crisis.

dlvr.it

Disease modification in lupus nephritis: towards a pathophysiology-based treatment paradigm

Nature Reviews Nephrology, Published online: 23 July 2026; doi:10.1038/s41581-026-01103-yThis Review provides an overview of the pathophysiology of systemic lupus erythematosus as well as drugs that have been developed to target these pathophysiological processes. The authors also synthesize a translational approach aimed at enabling disease modification in lupus nephritis through the integration of glucocorticoids and conventional antiproliferative agents with immunomodulatory drugs.

dlvr.it

Thymic health and implications for chronic kidney disease

Nature Reviews Nephrology, Published online: 16 July 2026; doi:10.1038/s41581-026-01104-xThe thymus is essential for T cell development and a decline in thymic health or a thymectomy therefore have profound clinical implications. Loss of thymic function might contribute to the uraemia-associated ageing of the T cell compartment, and new research is needed to clarify potential underlying mechanisms and effects on patient outcomes.

dlvr.it

Oscars’ inclusion standards for kidney trials

Nature Reviews Nephrology, Published online: 15 July 2026; doi:10.1038/s41581-026-01106-9Despite growing awareness of inequities in kidney research, high-impact trials remain predominantly led by men from high-income countries, and important disparities persist in the recruitment of women and populations disproportionately affected by chronic kidney disease. It is time to move beyond acknowledgement of such disparities and commit to inclusion standards that systemically transform kidney research.

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The kidney distal tubule potassium switch, modern diet and hypertension

Nature Reviews Nephrology, Published online: 14 July 2026; doi:10.1038/s41581-026-01099-5This Review focuses on the potassium switch signalling pathway and its regulation of urinary sodium excretion according to plasma potassium levels. Welling and colleagues examine how this pathway affects the interplay between potassium intake, salt handling in the kidney and blood pressure, and its implications for dietary interventions for blood pressure control.

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Metabolic determinants of autoimmune kidney diseases - Nature Reviews Nephrology

The differentiation and function of pathogenic immune cells that drive autoimmune diseases are in part controlled by their metabolic programming. This Review describes alterations in cellular metaboli...

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Next-generation kidney tissue analysis — spatial omics and digital pathology

Nature Reviews Nephrology, Published online: 13 July 2026; doi:10.1038/s41581-026-01102-zIn this Review, the authors discuss the advantages, limitations and applications of spatial omics technologies in kidney research. They also discuss novel imaging methods that may extend 2D spatial analyses into 3D modelling, and the complementary applicability of deep-learning-based computational pathology.

dlvr.it

Thymic health and implications for chronic kidney disease

Nature Reviews Nephrology, Published online: 16 July 2026; doi:10.1038/s41581-026-01104-xThe thymus is essential for T cell development and a decline in thymic health or a thymectomy therefore have profound clinical implications. Loss of thymic function might contribute to the uraemia-associated ageing of the T cell compartment, and new research is needed to clarify potential underlying mechanisms and effects on patient outcomes.

dlvr.it

Oscars’ inclusion standards for kidney trials

Nature Reviews Nephrology, Published online: 15 July 2026; doi:10.1038/s41581-026-01106-9Despite growing awareness of inequities in kidney research, high-impact trials remain predominantly led by men from high-income countries, and important disparities persist in the recruitment of women and populations disproportionately affected by chronic kidney disease. It is time to move beyond acknowledgement of such disparities and commit to inclusion standards that systemically transform kidney research.

dlvr.it

The kidney distal tubule potassium switch, modern diet and hypertension

Nature Reviews Nephrology, Published online: 14 July 2026; doi:10.1038/s41581-026-01099-5This Review focuses on the potassium switch signalling pathway and its regulation of urinary sodium excretion according to plasma potassium levels. Welling and colleagues examine how this pathway affects the interplay between potassium intake, salt handling in the kidney and blood pressure, and its implications for dietary interventions for blood pressure control.

dlvr.it

Next-generation kidney tissue analysis — spatial omics and digital pathology

Nature Reviews Nephrology, Published online: 13 July 2026; doi:10.1038/s41581-026-01102-zIn this Review, the authors discuss the advantages, limitations and applications of spatial omics technologies in kidney research. They also discuss novel imaging methods that may extend 2D spatial analyses into 3D modelling, and the complementary applicability of deep-learning-based computational pathology.

dlvr.it

Next-generation kidney tissue analysis — spatial omics and digital pathology

Nature Reviews Nephrology, Published online: 13 July 2026; doi:10.1038/s41581-026-01102-zIn this Review, the authors discuss the advantages, limitations and applications of spatial omics technologies in kidney research. They also discuss novel imaging methods that may extend 2D spatial analyses into 3D modelling, and the complementary applicability of deep-learning-based computational pathology.

dlvr.it

Metabolic determinants of autoimmune kidney diseases

Nature Reviews Nephrology, Published online: 06 July 2026; doi:10.1038/s41581-026-01096-8The differentiation and function of pathogenic immune cells that drive autoimmune diseases are in part controlled by their metabolic programming. This Review describes alterations in cellular metabolism associated with autoimmune diseases that affect the kidney, with a focus on lupus nephritis. The potential of therapies that target immunometabolism in autoimmune-induced kidney diseases is also discussed.

dlvr.it

Metabolic determinants of autoimmune kidney diseases

Nature Reviews Nephrology, Published online: 06 July 2026; doi:10.1038/s41581-026-01096-8The differentiation and function of pathogenic immune cells that drive autoimmune diseases are in part controlled by their metabolic programming. This Review describes alterations in cellular metabolism associated with autoimmune diseases that affect the kidney, with a focus on lupus nephritis. The potential of therapies that target immunometabolism in autoimmune-induced kidney diseases is also discussed.

dlvr.it