It begins.

Coming up this month...we've added an alternate/emo set...chose your flyer, we have rocker red or party pink!

Great review - pretty much sums up the field!! link.springer.com/article/10.1...

Computational prediction of TCR cross-reactivity: principles, challenges and translational opportunities - Journal of Translational Medicine

T-cell receptor (TCR) cross-reactivity, whereby a single TCR recognizes multiple peptide–MHC (pMHC) ligands, is essential for immune surveillance but also represents a major safety challenge for TCR-b...

link.springer.com

A Perspective discusses challenges in macromolecular ensemble prediction and the methodological advances that are needed. @stephanieaw.bsky.social www.nature.com/articles/s41...

From possibility to precision in macromolecular ensemble prediction - Nature Methods

This Perspective discusses current challenges in macromolecular ensemble prediction and the infrastructure and methodological advances needed to overcome these barriers.

nature.com

Short break from grant writing. New rehearsal space coming together.

New work from the lab showing how micropolymorphisms in HLA superfamilies can dramatically impact TCR specificity, even in the absence of changes to static structure or peptide binding. The secret's in how the peptides move around - or not, in the case of A0302 vs A0301. www.pnas.org/doi/full/10....

Dive bar tour begins (and ends?) in a week and half! Maybe we should decide on a tour poster.

I know paylines aren't a thing anymore, but I think this is ok...? T cell targets in transplantation, your time is coming! Thank you nice reviewers, even #3 I suppose!!! 😀

@gezelter.bsky.social

Huge congratulations to Chukwunalu "Chuks" Chukwuma for successfully defending his PhD thesis on interrogating the specificity of alloreactive T cells and the implications for organ transplant rejection! Another newly minted structural immunologist setting out to make the world a better place.

Lab people: "Hey, look at all these cool AI models, AlphaFold, Chai, Boltz, gazillion models per week, blah blah, cool new relationships, experiments schmeriments." Me, looking at one model: "Huh, arginine and tyrosine in the same volume of space, right where the receptor would sit. Nifty." Sigh.

Wonderful evening with the Rush Tribute Project in Indianapolis. Absolutely nailed every note. They make it look so easy. Wonderful guys - thank you! #Rush

Super surprised and super grateful, to the reviewers and more importantly the talented team and collaborators that made this possible (particularly @chadbrambley.bsky.social). I suppose we'll see how changes to advisory councils and MYF play out...?

The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5

Committee Releases Conferenced Defense, Homeland Security, Labor, Health and Human Services, Education, and Related Agencies, and Transportation, Housing and Urban Development, and Related Agencies Bi...

United States Senate Committee on Appropriations

appropriations.senate.gov

Latest preprint from the team: micropolymorphisms in HLAs tune peptide conformational ensembles, altering structural adaptability & contributing to TCR specificity. Even if static structures & pep affinites are the same, closely related HLAs may not be. #immunosky www.biorxiv.org/content/10.6...

HLA micropolymorphisms confine neoantigen conformational adaptability and guide T cell receptor selectivity

T cell receptor (TCR) restriction by highly polymorphic major histocompatibility complex (MHC) proteins is a foundation of cellular immunity. Although the effects of MHC polymorphisms on peptide bindi...

biorxiv.org

New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them? www.biorxiv.org/content/10.1...

Crystallographic Ensembles Reveal the Structural Basis of Binding Entropy in SARS-CoV2 Macrodomain

Structure-based drug design has traditionally focused on optimizing static, enthalpic interactions between ligands and proteins or on displacing binding site solvent molecules to entropically favor bi...

biorxiv.org

"Everything that isn’t a ghost is usually woven." LLMs’ style is hilarious but sobering: They make the curious word choices they do because that’s what most people rate as good writing. (PSA: When you see me using “delve,” “—”, and descriptive triplets, it’s really me!)

Why Does A.I. Write Like … That?

nytimes.com

Science will often take you to unexpected and delightful places. In this study, researchers hypothesized that riders in a crowded subway car would be more likely to offer their seat to a pregnant person if there were someone in the subway car dressed as Batman 🧪🦇 www.nature.com/articles/s44...

Hey #immunosky people - anyone got any experience encoding multiple MHC-I binding peptides in APCs using minigenes and care to give some advice?

Viral immunologist @pgtimmune.bsky.social, who recently joined Fred Hutch's Vaccine and Infectious Diseases Division, aims to harness the "incredible potential" of the immune system to advance diagnostics, vaccines and cancer therapies. bit.ly/3WJVpos

Viral immunologist taps ‘incredible potential’ of immune system

New Fred Hutch Cancer Center viral immunologist Dr. Paul Thomas is working to turn the "incredible potential" of the immune system into real-life diagnostic and therapeutic applications. He studies ho...

bit.ly

Happy to have been part of this work with Karen Hastings and team at the Univ of Arizona quantifying the impact of structure on neoAg immunogenicity. Kudos to @chadbrambley.bsky.social and the others for their awesome work. Look for modeling to improve neoAg prediction! jitc.bmj.com/content/13/1...

Structural changes from wild-type define tumor-rejecting neoantigens

Background Challenges in predicting which neoantigens mediate tumor rejection limit the efficacy of neoantigen vaccines to treat cancers, especially for cancers with a high mutational burden like cuta...

jitc.bmj.com

I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow

Texas Science@texasscience.bsky.social · 10mo ago

UT Austin has a new “genius grant” recipient! Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation. #TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social cns.utexas.edu/news/accolad...

Some thoughts on #Rush touring with a surprising choice of the super talented Anika Nilles for a drummer, instead of some of the bigger names that have been thrown around by everybody but Alex and Geddy over the years. Neil Peart of course eschewed the limelight.

It's a good day.

Rush is a Band@rushisaband.bsky.social · 10mo ago

🚨BREAKING NEWS!!!! 🚨 Geddy Lee and Alex Lifeson have decided to dust off their instruments and bring back the #Rush tour machine with new drummer Anika Nilles for a 7 city, 12 date tour in 2026! www.rushisaband.com/blog/2025/10...

Tom Sawyer is now airport music.

Lecturing on biomolecular equilibria this semester. This is in the classroom. Turns out it 100% lives up to the hype. Amazing stuff.

A big chunk of the lab works on TCR cross-reactivity - the subgroup is called TCR-X. They made an image for their T shirts... Well played, TCR-X. #immunosky

I can

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

I don't want to alarm anyone, but I think my electron density might be haunted. 💎👻💀