Christoph Schell, MD,PhD
@nephpath.bsky.social
Pathologist | Kidney Researcher | ECM&Matrix Fan | Uropathology #Podocyte #Glomerulus #Pathology Cyclist | Climber | Views are my own
A new exciting and highly collaborative @sfb1453.bsky.social paper by NephGen groups Börries, Schell, and Kühn in @pnas.org Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS www.pnas.org/doi/10.1073/...
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. Limited treatment options lead to renal failure in ...
pnas.org
Please spread the word and sign up for our exciting spring meeting in Nottingham with amazing speakers on the topic of ECM, immunity and infection. An exciting and developing field! paacr4.wixsite.com/bsmb-spring2...
Home | BSMBSpring2025
paacr4.wixsite.com
Our new paper put today @natureCVR led by @sikandhayat.bsky.social Tore Bleckwehl in collab with NovoNordisk 👇👇 www.nature.com/articles/s44...
Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis - Nature Cardiovascular Research
Bleckwehl et al. present a spatial transcriptomic map of atherosclerotic plaques across disease stages, revealing cellular recruitment and migration patterns and intercellular communication dynamics a...
nature.com
We are hiring!!! The labs of Oliver Schilling, Melanie Föll and the Schell/Matripath Lab at University Medical Center Freiburg are seeking for PhD students in the field of matrix and cancer research. Projects are part of #SFBNephgen.
Our manuscript describing #MatriCom, a web application we developed in collaboration with @valerioizzi.bsky.social to infer #ECM communication systems from #scRNASeq datasets is now available on @biorxivpreprint.bsky.social!
bioRxivpreprint@biorxivpreprint.bsky.social · 2y agoMatriCom: a scRNA-Seq data mining tool to infer ECM-ECM and cell-ECM communication systems https://www.biorxiv.org/content/10.1101/2024.12.10.627834v1
Check out our newest joint publication by @sfb1453.bsky.social PIs Anke Schumann, Christoph Schell @nephpath.bsky.social, Oliver Schilling and Michael Köttgen in #ScientificReports 👩🔬👨🔬🔬🎉. #NephSky @uniklinik-fr.bsky.social @uni-freiburg.de rdcu.be/d3UXF
Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias
Scientific Reports - Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias
rdcu.be
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
nature.com
Fun fact: Although scientific journals have existed in some form since the 1600s, external peer review only became standard in the 1970s. (So yeah… Einstein’s theories, Watson & Crick’s double helix, penicillin, insulin, etc. - all published without helpful comments from Reviewer 2.)
Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf
In depth analysis on the role of Angptl4 in diabetic kidney disease and potential for therapeutic intervention.. www.science.org/doi/10.1126/...
Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease
Angplt4 deficiency in podocytes and renal tubule cells is protective in diabetes.
science.org
www.nature.com/articles/s41...
KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation - Nature Communications
The role of the focal adhesion protein KANK1 in cancer progression is not yet clearly understood. Here the authors find that KANK1 competes with the polarity protein Scribble at cell-cell junctions fo...
nature.com
Fantastic MTB ride in the mystic Black Forest!
