Neufeldt Lab
@neufeldtlab.bsky.social
Organic and organometallic research at Montana State University. Established 2016. Mostly student-run account. Our views are our own.
The Neufeldt lab is looking to hire a postdoc for an experimental position (organic/organometallic chemistry): jobs.montana.edu/postings/52714
Postdoctoral Research Associate
The Neufeldt Lab is looking for a motivated postdoc to complete a federally funded chemistry research project.
jobs.montana.edu
Reveal your fate as a dihaloarene in cross-coupling. Will you retain a halide, or will you lose both of your halides in a double reaction? Roll the ligand and solvent dice to determine—but remember, the rules are different for aryl chlorides and bromides! [Cover art by co-author Matthew Sandin.]
Nate and Matt provide new mechanistic insight into over-arylation in Suzuki cross-couplings, and the surprising differences between dibromo vs. dichloroarenes. Currently free to read as an ACS editor's choice. pubs.acs.org/doi/10.1021/...
Selectivity for Exhaustive Cross-Coupling of Dihaloarenes Is Affected by the Interplay between the Halide Byproduct, Solvent, and Ligand
In dihaloarene cross-couplings, the step(s) that take place after reductive elimination and before the start of the next cycle influence selectivity for monofunctionalization versus difunctionalizatio...
pubs.acs.org
Our C2-selective C—S coupling of 2,4-dichloropyrimidine (work led by Oliver) was highlighted by Synfacts! www.thieme-connect.com/products/ejo...
Thieme E-Journals - Synfacts / Full Text
Thieme E-Books & E-Journals
thieme-connect.com
The memo on paused grants is also trying to cancel awarded grants (see last paragraph).
Not that we've been huge social media users, but we're migrating here from X. Latest: C2 selective cross-coupling of 2,4-dichloropyrimidine doi.org/10.1021/jacs... (our "holy grail" substrate for inverting site selectivity) and Sharon receives a PECASE (Biden administration) tinyurl.com/yc3de6e6
C2-Selective Palladium-Catalyzed C–S Cross-Coupling of 2,4-Dihalopyrimidines
Under most conditions, 2,4-dihalopyrimidines undergo substitution reactions at C4. Here we report that Pd(II) precatalysts supported by bulky N-heterocyclic carbene ligands uniquely effect C2-selectiv...
doi.org
