Tessera

Cancer cells are characteristic of neural cells. How can you conclude that NTN1, a well known neural factor, is only expressed by CAFs but not by cancer cells themselves? @cp-cancercell.bsky.social

Online Now: A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression

Studies like this focus on effect of host nerve on tumors routinely explained by transduction from neural factors of the nerve either directly/via other cells to other neural factors expressed by cancer cell But you guys never mentioned the neural feature of cancer cell @cp-cancercell.bsky.social

Online Now: A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression

The EMT community still cannot face EMT's essential flaws They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs link.springer.com/article/10.1...

Online Now: A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression

This study circumlocutiously illustrates the promoting effect of host nerves on cancer, &even shows involvement of the magical undefinable EMT stuff in this process, but without mentioning anything about neural cell feature of cancer cells. LOL @cp-cancercell.bsky.social

Online Now: A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression

hallmarks of cancer now also complicated. what is the 'central tenet'? NEURAL STEMNESS: the core property of cancer cells. It unifies cancer cell phenotypic traits how to co-target multiple capabilities? targeting neural stemness via differentiation @cp-trendscancer.bsky.social

“The latest iteration of the hallmarks-of-cancer framework has converged on a central tenet, that is, durable tumor control requires the co-targeting of multiple oncogenic capabilities rather than single-pathway inhibition” @cp-trendscancer.bsky.social www.cell.com/trends/cance...

“The latest iteration of the hallmarks-of-cancer framework has converged on a central tenet, that is, durable tumor control requires the co-targeting of multiple oncogenic capabilities rather than single-pathway inhibition” @cp-trendscancer.bsky.social www.cell.com/trends/cance...

Beyond one gene, one target: Next-generation precision oncology

The Drug Rediscovery Protocol by K. Verkerk, et al., operationalized nationwide biomarker-guided, off-label precision oncology. Yet outcomes (15.7% response rate) mirror a decade of studies, indicatin...

cell.com

LOL. You have forgotten that cancer cell is pluripotent You don't know what the hell is the so-called EMT You cannot tell what cancer stem cells/cancer stemness exactly mean But you know how to understand tumor heterogeneity nature.com/articles/s41... nature.com/articles/s41...

Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets

nature.com

The EMT community still cannot face EMT's essential flaws They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs link.springer.com/article/10.1...

math modelling of cancer cell plasticity by modelling epithelial-mesenchymal transition transition/plasticity. Math equations always look so elegant, tidy, and logically tight. But how do they model something illogical, eg EMT/EMP? @biorxiv-cancer.bsky.social www.biorxiv.org/content/10.6...

Those who believe that EMT/P is helpful for understanding cancer cell plasticity&other things should first figure out what the hell is the so-called EMT/P&how they can be helpful 'Lack of basic rationale in EMT/P....' link.springer.com/article/10.1... @biorxiv-cancer.bsky.social

math modelling of cancer cell plasticity by modelling epithelial-mesenchymal transition transition/plasticity. Math equations always look so elegant, tidy, and logically tight. But how do they model something illogical, eg EMT/EMP? @biorxiv-cancer.bsky.social www.biorxiv.org/content/10.6...

Cancer cell plasticity/invasion: understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/2... @biorxiv-cancer.bsky.social

math modelling of cancer cell plasticity by modelling epithelial-mesenchymal transition transition/plasticity. Math equations always look so elegant, tidy, and logically tight. But how do they model something illogical, eg EMT/EMP? @biorxiv-cancer.bsky.social www.biorxiv.org/content/10.6...

Cancer cell plasticity👇

math modelling of cancer cell plasticity by modelling epithelial-mesenchymal transition transition/plasticity. Math equations always look so elegant, tidy, and logically tight. But how do they model something illogical, eg EMT/EMP? @biorxiv-cancer.bsky.social www.biorxiv.org/content/10.6...

math modelling of cancer cell plasticity by modelling epithelial-mesenchymal transition transition/plasticity. Math equations always look so elegant, tidy, and logically tight. But how do they model something illogical, eg EMT/EMP? @biorxiv-cancer.bsky.social www.biorxiv.org/content/10.6...

Modelling phenotypic plasticity in cancer invasion and metastasis: from microscopic interactions to macroscopic dynamics

Cancer progression is driven by the interplay between cancer cell phenotypic variability regulated by EMT/MET, and cell-cell and cell-matrix interactions. Starting with an individual-based model, in w...

biorxiv.org

Understanding cancer cell &cancer complexity &cancer therapy &even the inverse correlation between cancer and Alzheimer's &... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/2...

preprints.org

When you talk about tumor heterogeneity&its mechanisms..blah blah blah.., do you know Cancer cells were the first cells in history proven to be pluripotent, & epithelial-mesenchymal transition is a scientifically groundless stuff &nobody can tell what the hell it is? www.nature.com/articles/s41...

Waddington landscape is always cited to explain the connection of development and cancer. But the paramount work on embryonic induction by Mangold&Spemann, which Waddington admired greatly, was almost never mentioned in cancer research.

When you talk about tumor heterogeneity&its mechanisms..blah blah blah.., do you know Cancer cells were the first cells in history proven to be pluripotent, & epithelial-mesenchymal transition is a scientifically groundless stuff &nobody can tell what the hell it is? www.nature.com/articles/s41...

When you talk about tumor heterogeneity&its mechanisms..blah blah blah.., do you know Cancer cells were the first cells in history proven to be pluripotent, & epithelial-mesenchymal transition is a scientifically groundless stuff &nobody can tell what the hell it is? www.nature.com/articles/s41...

Tumor heterogeneity: development, mechanisms, and therapeutic implications - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Tumor heterogeneity: development, mechanisms, and therapeutic implications

nature.com

Understand cancer metastasis? Then you should know the core property of cancer cell is neural stemness, and you should also know neural stem/crest/progenitor cells undergo single-cell migration EMT cannot help you understand metastasis, because nobody knows what EMT actually is.

Epithelial-mesenchymal transition is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many cancer patients are awaiting that), &keep instilling 'EMT knowledge' in young researchers. Sigh.

The EMT community still cannot face EMT's essential flaws directly They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs link.springer.com/article/10.1...

Epithelial-mesenchymal transition is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many cancer patients are awaiting that), &keep instilling 'EMT knowledge' in young researchers. Sigh.

Those who believe that EMT is helpful for understanding cancer and other things should first figure out what the hell is the so-called EMT&how it can be helpful 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1...

Epithelial-mesenchymal transition is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many cancer patients are awaiting that), &keep instilling 'EMT knowledge' in young researchers. Sigh.

Epithelial-mesenchymal transition is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many cancer patients are awaiting that), &keep instilling 'EMT knowledge' in young researchers. Sigh.

Ying Cao@neuralgrndstate.bsky.social · 4w ago

The EMT community still cannot face EMT's essential flaws directly They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs link.springer.com/article/10.1...

Lack of basic rationale in epithelial-mesenchymal transition and its related concepts - Cell & Bioscience

Epithelial–mesenchymal transition (EMT) is defined as a cellular process during which epithelial cells acquire mesenchymal phenotypes and behavior following the downregulation of epithelial features. ...

link.springer.com

Explaining the behavior of neural crest cells using EMT might be the weirdest thing in biology😘 Why? They say that NCCs express EMT factors TWIST1/SNAI1/2... But these are NCC markers/specifiers. Sounds like the birds behave like a pig because they grow feathers😉 www.nature.com/articles/s41...

Ying Cao@neuralgrndstate.bsky.social · 4w ago

Impact of EMT is profound EMT research reminds one of Pavlov's conditioned reflex effect Once symbols like TWIST1/SNAI1/2..are seen/heard, the tempting EMT stuff immediately comes to mind, &becomes totally immune to the knowledge of (neuro)developmental roles of these factors

Explaining the behavior of neural crest cells using EMT might be the weirdest thing in biology😘 Why? They say that NCCs express EMT factors TWIST1/SNAI1/2... But these are NCC markers/specifiers. Sounds like the birds behave like a pig because they grow feathers😉 www.nature.com/articles/s41...

Ying Cao@neuralgrndstate.bsky.social · 4w ago

Those who believe that EMT is helpful for understanding cancer and other things should first figure out what the hell is the so-called EMT&how it can be helpful 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1...

Explaining the behavior of neural crest cells using EMT might be the weirdest thing in biology😘 Why? They say that NCCs express EMT factors TWIST1/SNAI1/2... But these are NCC markers/specifiers. Sounds like the birds behave like a pig because they grow feathers😉 www.nature.com/articles/s41...