Dave Root

@neuronroot.bsky.social

Neuroscientist at CU Boulder. he/him. Mostly amplify other neuroscientists. www.root-lab.org

A really interesting finding from this study was a dissociation between affect & motivation: Stress induction increased self-administration despite the drug not actually helping people cope with the stress: no improvement in positive or negative affect (vs placebo)

Siri Leknes@sirileknes.bsky.social · last wk.

Major paper out: A heroic* demonstration that even acute stress increases drug intake in healthy people *4-session 2x2 RCT with ~4 oxycodone injections in 66 volunteers - with repeated blinded 2-panel stress/control inductions (ReSST) 1/🧵 www.nature.com/articles/s44...

We're hiring! Postdoc position to study the neural control of reaching using high-density multi-area electrophysiology. 5 years of funding, great collaborative environment. Please share with anyone who may be interested. For details, see: docs.google.com/document/d/1...

Pruszynski Postdoc 2026

Postdoctoral Researcher, Control Policies in the Primate Motor Circuit Pruszynski Lab @ Sensorimotor Superlab​ The Pruszynski Laboratory at Western University is seeking a postdoctoral researcher to j...

docs.google.com

Dopamine and sodium appetite! Sodium appetite causes a 'sign change' in the taste of hypertonic NaCl solutions. We've previously shown that generation of the appetite recruits phasic dopamine to the taste of NaCl; here we show the 'derecruitment' process during satiation.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2w ago

Rapidly decreasing phasic dopamine responses precede a hedonic switch during satiation of sodium appetite https://www.biorxiv.org/content/10.64898/2026.07.16.738888v1

Fresh from the Castro Lab! We characterize how mu opioid receptors on pancreatic alpha cells regulate ingestive phenotypes. Surprise! Mu can act both inside and outside the brain😱 Congrats to our technician Diego De Gregorio! @ssibsociety.bsky.social www.sciencedirect.com/science/arti...

Pancreatic mu opioid receptors regulate metabolism and ingestive behaviors

The mu opioid receptor system has long been recognized for its role in regulating ingestive behaviors and food palatability. However, beyond their rob…

sciencedirect.com

Our new study ⬇️inspired by the question: does psilocybin influence meta-learning and cortical processing of unexpected uncertainty? Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention