Excited for accepted #ACNP2027 panel co-chaired with @jojolab.bsky.social. @vikaassohal.bsky.social @suthanalab.bsky.social @rphillips3.bsky.social and Josh will present cross-species strategies that align rodent circuit interrogation w/ behavioral, physiological & molecular readouts in human 🧠

Studying norepinephrine? Have cool results to share? Want to join an online community of norepinephrine researchers? We are organizing our fall schedule for the Blue Spot Slack! We have monthly virtual seminars where you can share your work and get feedback in a supportive environment. Apply/join ⬇️

I am so thrilled to share that i was selected to received the 2026 BBRF young investigator grant from the @bbrfoundation.bsky.social. This is meaningful for me. Thanks so much to @martinowk.bsky.social and the @lieberinstitute.bsky.social for all the support.

2026 GRC Frontal Cortex August 9 - 14, 2026 Application deadline: July 12, 2026 👇🏼👇🏼👇🏼

Also apply for the GRS!! Great opportunity for trainees to present and networking.

GRC Frontal Cortex@grc-frontal-cortex.bsky.social · last mo.

Meet your #GRC-FrontalCortex chairs! Only 2 weeks left to apply! For more info: www.grc.org/frontal-cort...

Thrilled to share that our latest paper investigating how mPFC-LC projectors contribute to sustained #attention is now out in @npp-journal.bsky.social This is so meaningful to me and the team, Its @rehg-j.bsky.social first first-author paper and my first corresponding one. rdcu.be/fqBJp

Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

Neuropsychopharmacology - Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

rdcu.be

For #FluorescenceFriday, celebrating some more good paper news with this really pretty image labeling prefrontal cortical neurons with projections to the locus coeruleus with chemogenetic receptors. Image credit to @rehg-j.bsky.social @jorge-miranda.bsky.social 🧠🧪🔬

Yesterday I had the privilege to give a virtual talk to undergrad and graduate students in Mexico about some of our work at @lieberinstitute.bsky.social. It was great to connect with the community, and giving it in spanish felt so special. #cienciaenespañol!

For #FluorescenceFriday 🧠🔬🧪 - mPFC projection neurons heading to ventral tegmental area 🟢 or the locus coeruleus 🔴. Processes on some of these GPF+ neurons are just AMAZING! Image credit to our Circuits team! @jorge-miranda.bsky.social @rehg-j.bsky.social and Daniel Olivares!

It is so nice to see some mPFC neurons lighting up. Maybe they know its friday and they are also excited for the weekend like me. #fluorescenceFriday #miniscope

Great feeling for a friday. First cell from the new rig. Still a lot of work to do on the rig, but we are patching. Feels like going back to your first love ❤️ 😍

Our work characterizing the respiratory depression caused by opioids and alcohols is finally out in the world! pubmed.ncbi.nlm.nih.gov/41632547/

Potentiation of fentanyl-induced respiratory depression by alcohol is not fully reversed by naloxone - PubMed

The high frequency of opioid overdose deaths often involves co-use of alcohol, which is reported in approximately 30% of fentanyl fatalities. Both substances depress respiratory function, and their combined effects can be lethal. The present study investigated physiological parameters of respiratory …

pubmed.ncbi.nlm.nih.gov

For #FluorescenceFriday - unmistakably the blue spot 🔵 (locus coeruleus) - here labeled in a section of the mouse brain in pink with tyrosine hydroxylase (TH) 🔬🧠🧪 Image credit to the @lieberinstitute.bsky.social Circuits team - @jorge-miranda.bsky.social @rehg-j.bsky.social

Final paper of my PhD 🤗 www.nature.com/articles/s44... There is growing interest in how cognitive control may improve value-based decision making. However, we find that a recent paper overestimated the role of control in their task, leading to erroneous interpretations of dACC recordings.

Misspecified models create the appearance of adaptive control during value-based choice - Communications Psychology

In a new computational analysis of previous work, this study shows that a control-free mechanism better accounts for value-based decisions than an account that assumes top-down control invigorating th...

nature.com

Notice of Extension to Early-Stage Investigator (ESI) Eligibility Period by NIH: Investigators whose ESI end date was in Sept, Oct, or Nov 2025 will have ESI status extended through March 31, 2026 But what about if the end date was Dec 25 or Jan 26? grants.nih.gov/grants/guide...

For #FluorescenceFriday, activity-trapping experiments to better understand how amphetamine controls attention. RNAscope for glutamate neurons 🟢, inhibitory neurons 🔴 and our "ensemble" 🟣. Quotes for the loaded definition ;) Image credit to JHU neuro student Suhaas Adiraju 🧠🔬🧪

Oscillatory and aperiodic neural dynamics shape temporal perception and weighting of perceptual priors in ADHD profiles https://www.biorxiv.org/content/10.64898/2026.01.30.702812v1

So happy to share this preprint and so proud of @rehg-j.bsky.social and his hard work and determination. Here we showed circuit-specific effect after activation of mPFC-LC projectors to sustained attention during rCPT.

Jason Rehg@rehg-j.bsky.social · 8mo ago

Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention. 1/7 www.biorxiv.org/content/10.6...

Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention. 1/7 www.biorxiv.org/content/10.6...

Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)

The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and exp...

biorxiv.org

We are thrilled to announce that the preliminary program for the 2026 GRC on the Frontal Cortex is now live! www.grc.org/frontal-cort... Registration is now open for both the GRC and our GRS, chaired by @albitc.bsky.social and @jorge-miranda.bsky.social!

Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41... #Calicumimaging #miniscopes #rCPT #PrL

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry

Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

nature.com

New paper, studying time-on-task related decrements in the rodent continuous performance task (rCPT). CPTs are used to assess attentional function in clinical settings and have been adapted for mice (rCPT). Sustained attention is the ability to focus on an activity or stimulus over time,

NPP-Digital Psychiatry and Neuroscience (DPN)@dpn-journal.bsky.social · last yr.

🆕 in DPN from Greg Carr & @martinowk.bsky.social labs: Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task www.nature.com/articles/s44...