New secondary analysis from FLOW: losing weight and also not dying leads to improvemens in quality of life. This is truly a late breaking result… also the sky is still blue #nephsky #ERA26

Another negative trial in advanced CKD. Low dose rivaroxiban did not decrease CV risk in patients w CKD4-5 and high risk of CVD but the study was terminated early due to higher rates of major bleeding. Seems like a well done study. jamanetwork.com/journals/jam... #ERA26 #nephsky

Targeting NO in CKD? In ALPINE1 nurandociguat, which stimulates cGMP, leads to a significant but modest reduction in UACR in CKD w/wo DM2. This is on top of pretty good standard of care w. 70% sglt2i. But many did not high dose treatment. Will be interesting to follow #nephsky #ERA26 #ckd

The end of the road for rivaroxaban? Shows how important direct comparative trials among drugs within the same pharmacologic class are. #emimcc #cardiosky www.nejm.org/doi/full/10....

Finally, FINEONE shows Finerenone reduces albuminuria in T1DM www.nejm.org/doi/full/10.... @nejm.org #NephSKy

I like this as a mechanistic article examining why #SGLT2i’s work, but I don’t agree that renal fractional reserve can be used to identify patients most likely to benefit from SGLT2i since I think almost everybody with DM2 would benefit from SGLT2i #nephsky academic.oup.com/ndt/advance-...

Renal functional reserve predicts GFR response to empagliflozin in RENALIS and RACELINES clinical trials

AbstractBackground and hypothesis. Glomerular hyperfiltration is common in type 2 diabetes (T2D) and may reflect reduced nephron number and/or perturbed in

academic.oup.com

Glad to have contributed to this study, which has a very relevant clinical point: the BP lowering effect of SGLT2i of 4-5 mmHg is independent of renal function #nephsky #sglt2i

American Journal of Hypertension@amjhypertension.bsky.social · 8mo ago

The Effect of SGLT2 Inhibitors aka #Flozins on Blood Pressure in Relation to Baseline Kidney Function: A Systematic Literature Review and Data Analysis 🔗 academic.oup.com/ajh/article-... 🔒

Sodium glucose transporter 2 inhibition maintains kidney antibacterial response by decreasing complement C1q doi.org/10.1016/j.kint.2026.01.003 #OpenAccess #NephSky #MedSky #inflammation #pyelonephritis

Still interested in the mechanisms of #SGLT2i? I did a video with #Vumedi going through our study on the effects of empagliflozin on fluid and electrolyte balance. check it out: www.vumedi.com/video/fluid-... Link for the studies 👇 #medsky #nephsky

Fluid Balance in CKD: Empagliflozin Findings from SiRENA

A video from William Shaffer (as part of ASN Kidney Week Highlights), posted on Nov 26, 2025.

vumedi.com

Getting an early start on this years christmas decorations. My wife won’t let me put it up at home, so I guess I’ll bring it to work. #Nephsky #medsky

I think everyone is rightly sceptical if the large effect size, but given the high risk CVD risk and low cost/risk with fish oil, I feel it is too reactionary to just say “we need more trials”. We always need more trials, but they’re not likely to be forthcoming any time soon. #NephSky

REMODEL is fantastic demonstration of what we can do with collaborative effort to perform what Kathy Tuttle calls mechanistic clinical trials! Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk

Nothing works in dialysis - except fis oil. Truly amazing data from the PISCES. Should we begin perscribimg fish oil supplements to all our dialysis patients? In spite of my somewhat sceptical priors, I think the answer should be “yes” #NephSky #KidneyWk #nephrology

Check out our new paper! SGLT2i lower BP and the effect seems to be independent of baseline kidney function. A clinically relevant point, and something to take in to consideration when prescribing. #NephSky #MedSky #Hypertension #SGLT2i

American Journal of Hypertension@amjhypertension.bsky.social · last yr.

#WeekendReads from the #AdvanceAccess section Is the FLozin-BP effect modified by baseline GFR? An SR/MA 🔗 academic.oup.com/ajh/advance-... 🔒 #Hypertension #NephSky

#WeekendReads from the #AdvanceAccess section Is the FLozin-BP effect modified by baseline GFR? An SR/MA 🔗 academic.oup.com/ajh/advance-... 🔒 #Hypertension #NephSky