TTE continues to have a net negative effect on research by providing window dressing for undesigned studies. Biggest deficiency: TTE does nothing for confounding and barely mentions it. fharrell.com/post/causal

A randomized controlled non-inferiority trial examined lower dose prednisolone and activated vitamin D in adult minimal change podocytopathy doi.org/10.1016/j.kint.2026.02.035 #NephSky #MedSky #OpenAccess #NephroticSyndrome

& I will go one step further The A-C-D combo as first line is based on ALLHAT where Spiro was not on the table arguably Spiro could even be first line in primary hypertension if we did ALLHAT 2.0 Sodium (yes I am saying that) is so important that Spiro/HCTZ combo makes a great first line drug

Since atrasentan is bound to be approved for use in IgAN, does anyone know whether it will be revived for DKD? SONAR did in fact show that it was effective, but the premature termination and upstaging by CREDENCE sort of left atrasentan for dead… #askrenal

Interesting trial in @kidneyint@bsky.social www.kidney-international.org/article/S008... SLE with remission. No symptoms. When dsDNA becomes positive (or doubles) do you preemptively increase immunosuppression? #NephSky #RheumSky

"Over 80% of participants with obesity-related hypertension exhibited reproducible pathologic phenotypes of aldosteronism and/or hypercortisolism" www.jacc.org/doi/10.1016/...

Unmasking Hormonal Mechanisms of Hypertension in Obesity:

jacc.org

Research letter, pilot trial from Mayo ($locked) pubmed.ncbi.nlm.nih.gov/41802270/ Diuretic resistance is mostly inadequate furosemide dose. Torsemide not needed™️ (Incidence of deafness 🧏🏽‍♂️ not reported)

Is anyone using obinutuzumab for maintenance in SLE (I know there is no data)? Have young pt with LN III/IV, MMF + prednisone induction. Doing well, but persistently high dsDNA, C3/C4 normal. @kidneydoc101.bsky.social @juancarlosqvelez.bsky.social @kronbichlerlab.bsky.social @grahamabra.bsky.social

We report it for outpatients We don’t report it for inpatients - it’s easy to calculate if you want to

Very cool paper from Hamburg! Urinary CD4+ T cells identify Sjögren's patients with nephritis and help monitor treatment response! Awesome work! pubmed.ncbi.nlm.nih.gov/41673408/ #NephSky

Glomerular basement membrane (GBM) structural integrity dictates trans-tissu... www.sciencedirect.com/science/arti... Really proud of this Cell Reports paper showing that the potentially pathogenic laminin alpha2 in the Alport GBM comes not from glomerular cells, but from the bloodstream.

Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney

Basement membranes (BMs) are specialized extracellular matrices (ECMs) essential for tissue structure and function. In non-vertebrates, ECM components…

sciencedirect.com

The things that have changed or most influenced my approach to anemia are: Daniel Coyne DRIVE 2 PIVOTAL CHOIR/CREATE/TREAT (No KDOQI or KDIGO guideline) #NephJC

Or seeing a lot of young patients with positive cross-matches and with no other cause of allo-/isoimmunization. If not the principal cause of their symptoms/ death-treatening, I always think twice if it's worth it #nephjc

fun review if anyone is interested www.ahajournals.org/doi/10.1161/... Vaughan Pendred was a house surgeon at Guy's hospital when he reported deaf-mutism with goitre www.sciencedirect.com/science/arti... in @thelancet.com - and went on to become a ....(not nephrologist) a general practitioner

Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020 | Hypertension

Intercalated cells make up about a third of all cells within the connecting tubule and the collecting duct and are subclassified as type A, type B and non-A, non-B based on the subcellular distributio...

ahajournals.org

@dialysisbloke.bsky.social Applied the VIPAR protocol to a patient with cAMR, first time in our centre. Fingers crossed for positive results 🤞🏻 Just wanted to let you know that it’s being used out there 🤓

Another trial! Albumin 20% for septic shock Does not work - JAMA NO jamanetwork.com/journals/jam... #EMIMCC

#OTD 1917 David Finney b (d 12 Nov 2018) CBE FRS; ASA Fellow 1951; Royal Statistical Society President 1973. Pioneered statistical methods of experimental design, statistical computing, pharmacovigilance, biological assay & probit analysis. 1/3

Still interested in the mechanisms of #SGLT2i? I did a video with #Vumedi going through our study on the effects of empagliflozin on fluid and electrolyte balance. check it out: www.vumedi.com/video/fluid-... Link for the studies 👇 #medsky #nephsky

Fluid Balance in CKD: Empagliflozin Findings from SiRENA

A video from William Shaffer (as part of ASN Kidney Week Highlights), posted on Nov 26, 2025.

vumedi.com

Important study validating what has become my standard practice for relapsing MCD-NS

American Journal of Kidney Diseases@ajkd.bsky.social · 10mo ago

Response to Rituximab as a Maintenance Therapy in Adult Idiopathic Nephrotic Syndrome: A French Multicenter Cohort Study bit.ly/4pDdIsn

Join the Filtrate and Jon Barratt as he takes an IgAN inspired victory lap FF 86 Atacicept for IgAN www.nephjc.com/freelyfilter...

FF 86 Atacicept for IgAN with Jon Barratt — NephJC

FF 86 Atacicept for IgAN with Jon Barratt

nephjc.com

I’m a little shocked at this review of resistant hypertension in CKD. academic.oup.com/ckj/advance-... - Weird take on BP targets (there are other trials besides SPRINT) - Thiazides don’t work in CKD, except chlorthalidone (demonstrably false) - Don’t use spiro if eGFR <45 because hyperK ?!?!? 1/2

2025 Update on resistant hypertension in CKD: where do we stand and where do we go?

Abstract. Resistant hypertension is highly prevalent among individuals with chronic kidney disease (CKD) and is closely associated with accelerated decline

academic.oup.com

7. Personal level. Beyond his talent and expertise, I met an extraordinary man. Humble, altruistic, wise, friendly, and with a great sense of humor. I brought him a vacuolar cast tie as a present and he wore it proudly right away 🤩

1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:

Diagnosis unmasked. Young F with 2g proteinuria, weak +dsDNA. Membranous pattern, IF with C3 dominant staining. Pronase IF --> IgG-k. Membranous-like glomerulopathy with masked monotypic IgG-k deposits. Considered to be autoimmune; not MGRS. #renalpath #pathsky #nephsky.

Nothing works in dialysis - except fis oil. Truly amazing data from the PISCES. Should we begin perscribimg fish oil supplements to all our dialysis patients? In spite of my somewhat sceptical priors, I think the answer should be “yes” #NephSky #KidneyWk #nephrology

Not all heroes wear capes. xkcd.com/3163/

Repair Video

xkcd.com

What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)? In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13. www.biorxiv.org/content/10.1... 1/n #Nephsky 🧪

After a 40 minute handa on session where my station worked on kidney US we are back in the lecture room for a talk on lung ultrasound by Nathaniel Reisinger #KidneyWk

I enjoyed the Observer this morning @drjennings.bsky.social In my considered view politicians and public bodies should not be on Twitter is for the same reason that a candidate should not attend a townhall meeting where he was put on a lower chair and very loud music played whenever he spoke.