Nima Sharifi MD
@nimasharifimd.bsky.social
Scientific Director Desai Sethi Urology Institute Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine https://www.nimasharifilab.com
Behind the scenes of research in action: first author Nikou Fotouhi and Nima Sharifi showcase the many sides of scientific discovery.
Metabolic disturbances are a common side effect of ADT for prostate cancer doi.org/10.1172/JCI2... Here, @nimasharifimd.bsky.social & team unveil a surprising link between a common inherited enzyme variant that drives prostate cancer mortality & its effects on bile acid regulation.
A study dissects the way in which fasting or a fasting-mimicking diet augments the effect of hormonal therapy in a mouse model of breast cancer. Learn more: https://nej.md/4xdH58T Wondering how you might use this article in practice or teaching? AI Companion can help. Try it with this article.
What does fasting do to regulation of glucocorticoids? What does that mean for outcomes in steroid-dependent cancers? Glad to have the opportunity to share a Clinical Implications of Basic Research on fasting, glucocorticoids and breast cancer @nejm.org! www.nejm.org/doi/full/10....
Fasting, Glucocorticoids, and Breast Cancer | NEJM
A study dissects the way in which fasting or a fasting-mimicking diet augments the effect of hormonal therapy in a mouse model of breast cancer.
nejm.org
Androgen metabolism in prostate cancer: recent advances. Read more in #Endocrinology: https://bit.ly/4vUb451 #Androgens #Metabolism #Steroids @endocrinesociety.bsky.social
Androgen metabolism in prostate cancer: recent advances
Abstract. Androgen biosynthesis is physiologically necessary for generating the principal stimulus for androgen receptor (AR) signaling and thus plays an e
bit.ly
Really enjoyed this collaboration led by Juyeun Lee and Justin Lathia - now out @nature.com ! www.nature.com/articles/s41...
Androgen loss accelerates brain tumour growth via HPA axis activation - Nature
Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.
nature.com
Androgen metabolism in prostate cancer: recent advances - out in the May issue of Endocrinology! #urosky 🧪 #testosterone academic.oup.com/endo?login=f...
Endocrinology | Oxford Academic
An official journal of the Endocrine Society. Publishes novel research and mechanistic studies on regulation of receptor/hormone signals, gene expression, development, function, and disease at the mol...
academic.oup.com
Really cool findings by @zhipengawang.bsky.social on new mechanisms of ketones in @angewandtechemie.bsky.social! news.med.miami.edu/ketone-metab...
Top Chemistry Journal Highlights Miller School Discovery Linking Ketone Metabolism to Cell Signaling - InventUM
Desai Sethi Urology Institute's Dr. Nima Sharifi and Dr. Zhipeng Wang were named recipients of Prostate Cancer Foundation grants.
news.med.miami.edu
Hoping for a better year and more peaceful times ahead.
Serendipity, steroids and #science - a short story and perspective of 18 years for our research laboratory🧪 #medsky doi.org/10.1016/j.js...
Redirecting
doi.org
Androgen Metabolism in Prostate Cancer: Recent Advances #metabolism #testosterone #prostatecancer url: academic.oup.com/endo/article...
Androgen Metabolism in Prostate Cancer: Recent Advances
Abstract. Androgen biosynthesis is physiologically necessary for generating the principal stimulus for androgen receptor (AR) signaling and thus plays an e
academic.oup.com
onlinelibrary.wiley.com/doi/10.1002/...
Metabolomic Insights Into Saliva as a Non‐Invasive Surrogate for Serum to Enable Community‐Based Biomarker Investigation
Introduction Using serum metabolomics in Community-Based Participatory Research (CBPR) with underserved populations presents challenges due to the invasive nature of venipuncture, which limits longi...
onlinelibrary.wiley.com
Crows! They left a mystical feeling flying overhead in a rush. @carlbergstrom.com
Just 1 more week to go until the 3rd Miami Symposium on Human Metabolism. Register today! In addition to the speaker lineup, the poster titles are presenters are now up👇! 🧪 med.miami.edu/elp/miamimetab…
med.miami.edu
We are looking for a research associate with a working knowledge and interest in mass spectrometry of small molecules. If interested, please check this out! careers.miami.edu/us/en/job/R1...
Research Associate 1 in Miami, Florida, United States of America | Research at University of Miami
Apply for Research Associate 1 job with University of Miami in Miami, Florida, United States of America. Research at University of Miami
careers.miami.edu
Congratulations @zhipengawang.bsky.social and team! What an incredible discovery in #metabolism and protein modification! It turns out acetoacetate is converted to another metabolite that modifies cysteines! 🧪
@zhipengawang.bsky.social · 7mo agoMy first research paper as an independent PI is now online. Thank you to the authors for contributions and to the reviewers for thoughtful and constructive comments. Grateful to the editor for the opportunity. onlinelibrary.wiley.com/doi/10.1002/...
Are you a postdoc or PhD student? Working on #metabolism? Escape the snow, apply for a travel award & submit an abstract for the 3rd #Miami Symposium on Human Metabolism on February 14, 2026! 🧪 The deadline is 12/31! Submit here: med.miami.edu/elp/miamimet...
Poster Session & Reception
Official website for the University of Miami Leonard M. Miller School of Medicine
med.miami.edu
Very excited our story on a CYP17A1-independent androgen biosynthesis pathway is out! Could explain why androgens are left when we use abiraterone to block CYP17A1 clinically in prostate cancer. Need to look more closely at oxidized forms of cholesterol! Please read the whole paper. 🧪 rdcu.be/eS7kU
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
science.org
Big and well deserved congratulations to @zhipengawang.bsky.social for his new Prostate Cancer Foundation Young Investigator Award! So well deserved! He is doing incredible work discovering new mechanisms of ketones in metabolism. And congrats to all the other PCF young investigator awardees! 🧪
